Analytical Chemistry

, volume 95 , issue 20 , pages 7822-7829

Parahydrogen in Reversible Exchange Induces Long-Lived ¹⁵N Hyperpolarization of Anticancer Drugs Anastrozole and Letrozole

Keilian Macculloch ¹

Austin Browning ¹

Patrick TomHon ¹

Sören Lehmkuhl ¹

Eduard Chekmenev ^{2, 3, 4}

Thomas Theis ^{1, 5, 6}

Hide authors affiliations Show authors affiliations: 6 affiliations

Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27606, United States |

Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States |

Integrative Biosciences (Ibio), Wayne State University, Karmanos Cancer Institute (KCI), Detroit, Michigan 48202, United States |

⁴

Russian Academy of Sciences, Leninskiy Prospekt 14, 119991 Moscow, Russia |

⁵

Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill and North Carolina State University, Raleigh, North Carolina 27606, United States |

⁶

Department of Physics, North Carolina State University, Raleigh, North Carolina 27606, United States |

Publication type: Journal Article

Publication date: 2023-05-10

American Chemical Society (ACS)

Analytical Chemistry

scimago Q1

wos Q1

SJR: 1.533

CiteScore: 11.6

Impact factor: 6.7

ISSN: 00032700, 15206882, 21542686

DOI: 10.1021/acs.analchem.2c04817

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PubMed ID: 37163687

Analytical Chemistry

Abstract

Hyperpolarization modalities overcome the sensitivity limitations of NMR and unlock new applications. Signal amplification by reversible exchange (SABRE) is a particularly cheap, quick, and robust hyperpolarization modality. Here, we employ SABRE for simultaneous chemical exchange of parahydrogen and nitrile-containing anticancer drugs (letrozole or anastrozole) to enhance

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Macculloch K. et al. Parahydrogen in Reversible Exchange Induces Long-Lived 15N Hyperpolarization of Anticancer Drugs Anastrozole and Letrozole // Analytical Chemistry. 2023. Vol. 95. No. 20. pp. 7822-7829.

GOST all authors (up to 50) Copy

Macculloch K., Browning A., TomHon P., Lehmkuhl S., Chekmenev E., Theis T. Parahydrogen in Reversible Exchange Induces Long-Lived 15N Hyperpolarization of Anticancer Drugs Anastrozole and Letrozole // Analytical Chemistry. 2023. Vol. 95. No. 20. pp. 7822-7829.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/acs.analchem.2c04817

UR - https://pubs.acs.org/doi/10.1021/acs.analchem.2c04817

TI - Parahydrogen in Reversible Exchange Induces Long-Lived 15N Hyperpolarization of Anticancer Drugs Anastrozole and Letrozole

T2 - Analytical Chemistry

AU - Macculloch, Keilian

AU - Browning, Austin

AU - TomHon, Patrick

AU - Lehmkuhl, Sören

AU - Chekmenev, Eduard

AU - Theis, Thomas

PY - 2023

DA - 2023/05/10

PB - American Chemical Society (ACS)

SP - 7822-7829

IS - 20

VL - 95

PMID - 37163687

SN - 0003-2700

SN - 1520-6882

SN - 2154-2686

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2023_Macculloch,

author = {Keilian Macculloch and Austin Browning and Patrick TomHon and Sören Lehmkuhl and Eduard Chekmenev and Thomas Theis},

title = {Parahydrogen in Reversible Exchange Induces Long-Lived 15N Hyperpolarization of Anticancer Drugs Anastrozole and Letrozole},

journal = {Analytical Chemistry},

year = {2023},

volume = {95},

publisher = {American Chemical Society (ACS)},

month = {may},

url = {https://pubs.acs.org/doi/10.1021/acs.analchem.2c04817},

number = {20},

pages = {7822--7829},

doi = {10.1021/acs.analchem.2c04817}

}

MLA

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MLA Copy

Macculloch, Keilian, et al. “Parahydrogen in Reversible Exchange Induces Long-Lived 15N Hyperpolarization of Anticancer Drugs Anastrozole and Letrozole.” Analytical Chemistry, vol. 95, no. 20, May. 2023, pp. 7822-7829. https://pubs.acs.org/doi/10.1021/acs.analchem.2c04817.

Publisher

American Chemical Society (ACS)

Journal

Analytical Chemistry

scimago Q1

wos Q1

SJR

1.533

CiteScore

11.6

Impact factor

6.7

ISSN

00032700 (Print)

15206882 (Electronic)

21542686 (Print)

Profiles

Eduard Y Chekmenev