A Selective Imidazoline-2-thione-Bearing Two-Photon Fluorescent Probe for Hypochlorous Acid in Mitochondria
Qingling Xu
1
,
Cheol Ho Heo
2
,
Jin-A Kim
1
,
Hye Sue Lee
2
,
Ying Hu
1
,
Da-Young Kim
1
,
Kunemadihalli Mathada Kotraiah Swamy
1, 3
,
Gyoungmi Kim
1
,
Sang Jip Nam
1
,
Hwan Myung Kim
2
,
3
Department
of Pharmaceutical Chemistry, V. L. College of Pharmacy, Raichur 584-103, Karnataka, India
|
Тип публикации: Journal Article
Дата публикации: 2016-06-02
scimago Q1
wos Q1
БС1
SJR: 1.533
CiteScore: 11.6
Impact factor: 6.7
ISSN: 00032700, 15206882, 21542686
PubMed ID:
27212708
Analytical Chemistry
Краткое описание
Hypochlorite (OCl(-)) plays a key role in the immune system and is involved in various diseases. Accordingly, direct detection of endogenous OCl(-) at the subcellular level is important for understanding inflammation and cellular apoptosis. In the current study, a two-photon fluorescent off/on probe (PNIS) bearing imidazoline-2-thione as an OCl(-) recognition unit and triphenylphosphine (TPP) as a mitochondrial-targeting group was synthesized and examined for its ability to image mitochondrial OCl(-) in situ. This probe, based on the specific reaction between imidazoline-2-thione and OCl(-), displayed a selective fluorescent off/on response to OCl(-) with the various reactive oxygen species in a physiological medium. PNIS was successfully applied to image of endogenously produced mitochondrial OCl(-) in live RAW 264.7 cells via two-photon microscopy.
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Метрики
170
Всего цитирований:
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Цитирований c 2024:
12
(7.06%)
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ГОСТ |
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BibTex |
MLA
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ГОСТ
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Xu Q. et al. A Selective Imidazoline-2-thione-Bearing Two-Photon Fluorescent Probe for Hypochlorous Acid in Mitochondria // Analytical Chemistry. 2016. Vol. 88. No. 12. pp. 6615-6620.
ГОСТ со всеми авторами (до 50)
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Xu Q., Heo C. H., Kim J., Lee H. S., Hu Y., Kim D., Swamy K. M. K., Kim G., Nam S. J., Kim H. M., Yoon J. A Selective Imidazoline-2-thione-Bearing Two-Photon Fluorescent Probe for Hypochlorous Acid in Mitochondria // Analytical Chemistry. 2016. Vol. 88. No. 12. pp. 6615-6620.
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TY - JOUR
DO - 10.1021/acs.analchem.6b01738
UR - https://doi.org/10.1021/acs.analchem.6b01738
TI - A Selective Imidazoline-2-thione-Bearing Two-Photon Fluorescent Probe for Hypochlorous Acid in Mitochondria
T2 - Analytical Chemistry
AU - Xu, Qingling
AU - Heo, Cheol Ho
AU - Kim, Jin-A
AU - Lee, Hye Sue
AU - Hu, Ying
AU - Kim, Da-Young
AU - Swamy, Kunemadihalli Mathada Kotraiah
AU - Kim, Gyoungmi
AU - Nam, Sang Jip
AU - Kim, Hwan Myung
AU - Yoon, Juyoung
PY - 2016
DA - 2016/06/02
PB - American Chemical Society (ACS)
SP - 6615-6620
IS - 12
VL - 88
PMID - 27212708
SN - 0003-2700
SN - 1520-6882
SN - 2154-2686
ER -
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BibTex (до 50 авторов)
Скопировать
@article{2016_Xu,
author = {Qingling Xu and Cheol Ho Heo and Jin-A Kim and Hye Sue Lee and Ying Hu and Da-Young Kim and Kunemadihalli Mathada Kotraiah Swamy and Gyoungmi Kim and Sang Jip Nam and Hwan Myung Kim and Juyoung Yoon},
title = {A Selective Imidazoline-2-thione-Bearing Two-Photon Fluorescent Probe for Hypochlorous Acid in Mitochondria},
journal = {Analytical Chemistry},
year = {2016},
volume = {88},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://doi.org/10.1021/acs.analchem.6b01738},
number = {12},
pages = {6615--6620},
doi = {10.1021/acs.analchem.6b01738}
}
Цитировать
MLA
Скопировать
Xu, Qingling, et al. “A Selective Imidazoline-2-thione-Bearing Two-Photon Fluorescent Probe for Hypochlorous Acid in Mitochondria.” Analytical Chemistry, vol. 88, no. 12, Jun. 2016, pp. 6615-6620. https://doi.org/10.1021/acs.analchem.6b01738.