Analytical Chemistry, volume 90, issue 11, pages 6702-6709
Near-Infrared Fluorescent Ag2S Nanodot-Based Signal Amplification for Efficient Detection of Circulating Tumor Cells
Publication type: Journal Article
Publication date: 2018-05-03
Journal:
Analytical Chemistry
Q1
Q1
SJR: 1.621
CiteScore: 12.1
Impact factor: 6.7
ISSN: 00032700, 15206882, 21542686
Analytical Chemistry
Abstract
The level of circulating tumor cells (CTCs) plays a critical role in tumor metastasis and personalized therapy, but it is challenging for highly efficient capture and detection of CTCs because of the extremely low concentration in peripheral blood. Herein, we report near-infrared fluorescent Ag2S nanodot-based signal amplification combing with immune-magnetic spheres (IMNs) for highly efficient magnetic capture and ultrasensitive fluorescence labeling of CTCs. The near-infrared fluorescent Ag2S nanoprobe has been successfully constructed through hybridization chain reactions using aptamer-modified Ag2S nanodots, which can extremely improve the imaging sensitivity and reduce background signal of blood samples. Moreover, the antiepithelial-cell-adhesion-molecule (EpCAM) antibody-labeled magnetic nanospheres have been used for highly capture rare tumor cells in whole blood. The near-infrared nanoprobe with signal amplification and IMNs platform exhibits excellent performance in efficient capture and detection of CTCs, which shows great potential in cancer diagnostics and therapeutics.
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Ding C. et al. Near-Infrared Fluorescent Ag2S Nanodot-Based Signal Amplification for Efficient Detection of Circulating Tumor Cells // Analytical Chemistry. 2018. Vol. 90. No. 11. pp. 6702-6709.
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Ding C., Zhang C., Yin X., Cao X., Cai M., Xian Y. Near-Infrared Fluorescent Ag2S Nanodot-Based Signal Amplification for Efficient Detection of Circulating Tumor Cells // Analytical Chemistry. 2018. Vol. 90. No. 11. pp. 6702-6709.
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TY - JOUR
DO - 10.1021/acs.analchem.8b00514
UR - https://doi.org/10.1021/acs.analchem.8b00514
TI - Near-Infrared Fluorescent Ag2S Nanodot-Based Signal Amplification for Efficient Detection of Circulating Tumor Cells
T2 - Analytical Chemistry
AU - Ding, Caiping
AU - Zhang, Cuiling
AU - Yin, Xueyang
AU - Cao, Xuanyu
AU - Cai, Meifang
AU - Xian, Yuezhong
PY - 2018
DA - 2018/05/03
PB - American Chemical Society (ACS)
SP - 6702-6709
IS - 11
VL - 90
SN - 0003-2700
SN - 1520-6882
SN - 2154-2686
ER -
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@article{2018_Ding,
author = {Caiping Ding and Cuiling Zhang and Xueyang Yin and Xuanyu Cao and Meifang Cai and Yuezhong Xian},
title = {Near-Infrared Fluorescent Ag2S Nanodot-Based Signal Amplification for Efficient Detection of Circulating Tumor Cells},
journal = {Analytical Chemistry},
year = {2018},
volume = {90},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/acs.analchem.8b00514},
number = {11},
pages = {6702--6709},
doi = {10.1021/acs.analchem.8b00514}
}
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Ding, Caiping, et al. “Near-Infrared Fluorescent Ag2S Nanodot-Based Signal Amplification for Efficient Detection of Circulating Tumor Cells.” Analytical Chemistry, vol. 90, no. 11, May. 2018, pp. 6702-6709. https://doi.org/10.1021/acs.analchem.8b00514.