том 28 издание 8 страницы 2109-2113

GlcNAc Conjugated Atorvastatin with Enhanced Water Solubility and Cellular Internalization

Тип публикацииJournal Article
Дата публикации2017-08-07
scimago Q1
wos Q1
БС1
SJR1.035
CiteScore7.5
Impact factor3.9
ISSN10431802, 15204812
Organic Chemistry
Pharmacology
Pharmaceutical Science
Biotechnology
Bioengineering
Biomedical Engineering
Краткое описание
Targeting ligands facilitate cell specific drug delivery and improve pharmaceutical properties. Herein, we designed two ligand drug conjugates by conjugating GlcNAc (N-acetylglucosamine) with atorvastatin. These two conjugates, termed G-AT and G-K-AT, exhibited enhanced water solubility and cellular uptake. Moreover, both G-AT and G-K-AT were able to release atorvastatin and consequently achieve significant inhibition against 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase.
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Журналы

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Bioconjugate Chemistry
1 публикация, 25%
Bioorganic and Medicinal Chemistry
1 публикация, 25%
Canadian Journal of Chemical Engineering
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Journal of Medicinal Chemistry
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American Chemical Society (ACS)
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Elsevier
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Wiley
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ГОСТ |
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Zhang X. et al. GlcNAc Conjugated Atorvastatin with Enhanced Water Solubility and Cellular Internalization // Bioconjugate Chemistry. 2017. Vol. 28. No. 8. pp. 2109-2113.
ГОСТ со всеми авторами (до 50) Скопировать
Zhang X., Chen X., Zhao W., Zeng C., Luo X., Li W., Li B., Jiang J., Dong Y. GlcNAc Conjugated Atorvastatin with Enhanced Water Solubility and Cellular Internalization // Bioconjugate Chemistry. 2017. Vol. 28. No. 8. pp. 2109-2113.
RIS |
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TY - JOUR
DO - 10.1021/acs.bioconjchem.7b00295
UR - https://doi.org/10.1021/acs.bioconjchem.7b00295
TI - GlcNAc Conjugated Atorvastatin with Enhanced Water Solubility and Cellular Internalization
T2 - Bioconjugate Chemistry
AU - Zhang, Xinfu
AU - Chen, Xiaofang
AU - Zhao, Wei-Yu
AU - Zeng, Chunxi
AU - Luo, Xiao
AU - Li, Wenqing
AU - Li, Bin
AU - Jiang, Justin
AU - Dong, Yizhou
PY - 2017
DA - 2017/08/07
PB - American Chemical Society (ACS)
SP - 2109-2113
IS - 8
VL - 28
PMID - 28745862
SN - 1043-1802
SN - 1520-4812
ER -
BibTex |
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@article{2017_Zhang,
author = {Xinfu Zhang and Xiaofang Chen and Wei-Yu Zhao and Chunxi Zeng and Xiao Luo and Wenqing Li and Bin Li and Justin Jiang and Yizhou Dong},
title = {GlcNAc Conjugated Atorvastatin with Enhanced Water Solubility and Cellular Internalization},
journal = {Bioconjugate Chemistry},
year = {2017},
volume = {28},
publisher = {American Chemical Society (ACS)},
month = {aug},
url = {https://doi.org/10.1021/acs.bioconjchem.7b00295},
number = {8},
pages = {2109--2113},
doi = {10.1021/acs.bioconjchem.7b00295}
}
MLA
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Zhang, Xinfu, et al. “GlcNAc Conjugated Atorvastatin with Enhanced Water Solubility and Cellular Internalization.” Bioconjugate Chemistry, vol. 28, no. 8, Aug. 2017, pp. 2109-2113. https://doi.org/10.1021/acs.bioconjchem.7b00295.