High Singlet Oxygen Yield Photosensitizer Based Polypeptide Nanoparticles for Low-Power Near-Infrared Light Imaging-Guided Photodynamic Therapy
Publication type: Journal Article
Publication date: 2018-09-06
scimago Q1
wos Q1
SJR: 1.035
CiteScore: 7.5
Impact factor: 3.9
ISSN: 10431802, 15204812
PubMed ID:
30185031
Organic Chemistry
Pharmacology
Pharmaceutical Science
Biotechnology
Bioengineering
Biomedical Engineering
Abstract
NIR photosensitizer is attractive for photodynamic therapy (PDT). Low-power light irradiation and imaging-guided PDT makes it possible to increase tissue penetration depth. The pyrrole-substituted iodinated BODIPY (BDPI) molecule was designed and synthesized, and it possesses an intense NIR absorption and emission band, and exhibits a high singlet oxygen quantum yield (ΦΔ = 0.80) which leads remarkable cytotoxicity upon low power illumination (IC50 = 0.60 μg/mL, 6.1 mW/cm2). After being encapsulated with biocompatibility polypeptide PEG-PLys, polymeric micelles nanoparticles (PBDPI NPs) was obtained that are water-dispersed and passively tumor-targetable. Such enhanced accumulation in tumor area makes it easily traced in vivo due to its NIR fluorescence. In addition, such nanoparticles offer an unprecedented photodynamic therapeutic effect by using a low-power irradiation light, which makes it possible to kill cancer cells in deep tissue efficiently.
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29
Total citations:
29
Citations from 2024:
5
(17.24%)
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GOST
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Ruan Z. et al. High Singlet Oxygen Yield Photosensitizer Based Polypeptide Nanoparticles for Low-Power Near-Infrared Light Imaging-Guided Photodynamic Therapy // Bioconjugate Chemistry. 2018. Vol. 29. No. 10. pp. 3441-3451.
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Ruan Z., Miao W., Yuan P., Liu L., Jiao L., Hao E., Yan L. High Singlet Oxygen Yield Photosensitizer Based Polypeptide Nanoparticles for Low-Power Near-Infrared Light Imaging-Guided Photodynamic Therapy // Bioconjugate Chemistry. 2018. Vol. 29. No. 10. pp. 3441-3451.
Cite this
RIS
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TY - JOUR
DO - 10.1021/acs.bioconjchem.8b00576
UR - https://doi.org/10.1021/acs.bioconjchem.8b00576
TI - High Singlet Oxygen Yield Photosensitizer Based Polypeptide Nanoparticles for Low-Power Near-Infrared Light Imaging-Guided Photodynamic Therapy
T2 - Bioconjugate Chemistry
AU - Ruan, Zheng
AU - Miao, Wei
AU - Yuan, Pan
AU - Liu, Le
AU - Jiao, Lijuan
AU - Hao, Erhong
AU - Yan, Lifeng
PY - 2018
DA - 2018/09/06
PB - American Chemical Society (ACS)
SP - 3441-3451
IS - 10
VL - 29
PMID - 30185031
SN - 1043-1802
SN - 1520-4812
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Ruan,
author = {Zheng Ruan and Wei Miao and Pan Yuan and Le Liu and Lijuan Jiao and Erhong Hao and Lifeng Yan},
title = {High Singlet Oxygen Yield Photosensitizer Based Polypeptide Nanoparticles for Low-Power Near-Infrared Light Imaging-Guided Photodynamic Therapy},
journal = {Bioconjugate Chemistry},
year = {2018},
volume = {29},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021/acs.bioconjchem.8b00576},
number = {10},
pages = {3441--3451},
doi = {10.1021/acs.bioconjchem.8b00576}
}
Cite this
MLA
Copy
Ruan, Zheng, et al. “High Singlet Oxygen Yield Photosensitizer Based Polypeptide Nanoparticles for Low-Power Near-Infrared Light Imaging-Guided Photodynamic Therapy.” Bioconjugate Chemistry, vol. 29, no. 10, Sep. 2018, pp. 3441-3451. https://doi.org/10.1021/acs.bioconjchem.8b00576.