Polycations for Gene Delivery: Dilemmas and Solutions
3
Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, P. R. China
|
Publication type: Journal Article
Publication date: 2018-11-01
scimago Q1
wos Q1
SJR: 1.035
CiteScore: 7.5
Impact factor: 3.9
ISSN: 10431802, 15204812
PubMed ID:
30383373
Organic Chemistry
Pharmacology
Pharmaceutical Science
Biotechnology
Bioengineering
Biomedical Engineering
Abstract
Gene therapy has been a promising strategy for treating numerous gene-associated human diseases by altering specific gene expressions in pathological cells. Application of nonviral gene delivery is hindered by various dilemmas encountered in systemic gene therapy. Therefore, solutions must be established to address the unique requirements of gene-based treatment of diseases. This review will particularly highlight the dilemmas in polycation-based gene therapy by systemic treatment. Several promising strategies, which are expected to overcome these challenges, will be briefly reviewed. This review will also explore the development of polycation-based gene delivery systems for clinical applications.
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76
Total citations:
76
Citations from 2025:
7
(9.21%)
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GOST
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Chen J. et al. Polycations for Gene Delivery: Dilemmas and Solutions // Bioconjugate Chemistry. 2018. Vol. 30. No. 2. pp. 338-349.
GOST all authors (up to 50)
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Chen J., Wang K., Wu J., Tian H., Chen X. Polycations for Gene Delivery: Dilemmas and Solutions // Bioconjugate Chemistry. 2018. Vol. 30. No. 2. pp. 338-349.
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RIS
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TY - JOUR
DO - 10.1021/acs.bioconjchem.8b00688
UR - https://doi.org/10.1021/acs.bioconjchem.8b00688
TI - Polycations for Gene Delivery: Dilemmas and Solutions
T2 - Bioconjugate Chemistry
AU - Chen, Jie
AU - Wang, Kui
AU - Wu, Jiayan
AU - Tian, Huayu
AU - Chen, Xuesi
PY - 2018
DA - 2018/11/01
PB - American Chemical Society (ACS)
SP - 338-349
IS - 2
VL - 30
PMID - 30383373
SN - 1043-1802
SN - 1520-4812
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Chen,
author = {Jie Chen and Kui Wang and Jiayan Wu and Huayu Tian and Xuesi Chen},
title = {Polycations for Gene Delivery: Dilemmas and Solutions},
journal = {Bioconjugate Chemistry},
year = {2018},
volume = {30},
publisher = {American Chemical Society (ACS)},
month = {nov},
url = {https://doi.org/10.1021/acs.bioconjchem.8b00688},
number = {2},
pages = {338--349},
doi = {10.1021/acs.bioconjchem.8b00688}
}
Cite this
MLA
Copy
Chen, Jie, et al. “Polycations for Gene Delivery: Dilemmas and Solutions.” Bioconjugate Chemistry, vol. 30, no. 2, Nov. 2018, pp. 338-349. https://doi.org/10.1021/acs.bioconjchem.8b00688.