Phospholipidic Colchicinoids as Promising Prodrugs Incorporated into Enzyme-Responsive Liposomes: Chemical, Biophysical, and Enzymological Aspects
Ekaterina S. Shchegravina
1, 2
,
Anna Alekseeva
2
,
T. Galimzyanov
3, 4
,
Yu. N. Utkin
2
,
Yuri A. Ermakov
3
,
Natalia Yu Karpechenko
6
,
E. L. Vodovozova
2
,
H.-G. Schmalz
1
,
Publication type: Journal Article
Publication date: 2019-02-28
scimago Q1
wos Q1
SJR: 1.035
CiteScore: 7.5
Impact factor: 3.9
ISSN: 10431802, 15204812
PubMed ID:
30817133
Organic Chemistry
Pharmacology
Pharmaceutical Science
Biotechnology
Bioengineering
Biomedical Engineering
Abstract
Enzyme-responsive liposomes release their cargo in response to pathologically increased levels of enzymes at the target site. We report herein an assembly of phospholipase A2-responsive liposomes based on colchicinoid lipid prodrugs incorporated into lipid bilayer of the nanosized vesicles. The liposomes were constructed to addresses two important issues: (i) the lipid prodrugs were designed to fit the structure of the enzyme binding site; and (ii) the concept of lateral pressure profile was used to design lipid prodrugs that introduce almost no distortions into the lipid bilayer packing, thus ensuring that corresponding liposomes are stable. The colchicinoid agents exhibit antiproliferative activity in subnanomolar range of concentrations.
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Metrics
26
Total citations:
26
Citations from 2024:
8
(30.77%)
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RIS |
BibTex |
MLA
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GOST
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Shchegravina E. S. et al. Phospholipidic Colchicinoids as Promising Prodrugs Incorporated into Enzyme-Responsive Liposomes: Chemical, Biophysical, and Enzymological Aspects // Bioconjugate Chemistry. 2019. Vol. 30. No. 4. pp. 1098-1113.
GOST all authors (up to 50)
Copy
Shchegravina E. S., Tretiakova D. S., Alekseeva A., Galimzyanov T., Utkin Y. N., Ermakov Y. A., Svirshchevskaya E. V., Negrebetsky V. V., Karpechenko N. Yu., Chernikov V. P., Onishchenko N. R., Vodovozova E. L., Schmalz H., Boldyrev I. A. Phospholipidic Colchicinoids as Promising Prodrugs Incorporated into Enzyme-Responsive Liposomes: Chemical, Biophysical, and Enzymological Aspects // Bioconjugate Chemistry. 2019. Vol. 30. No. 4. pp. 1098-1113.
Cite this
RIS
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TY - JOUR
DO - 10.1021/acs.bioconjchem.9b00051
UR - https://doi.org/10.1021/acs.bioconjchem.9b00051
TI - Phospholipidic Colchicinoids as Promising Prodrugs Incorporated into Enzyme-Responsive Liposomes: Chemical, Biophysical, and Enzymological Aspects
T2 - Bioconjugate Chemistry
AU - Shchegravina, Ekaterina S.
AU - Tretiakova, Daria S.
AU - Alekseeva, Anna
AU - Galimzyanov, T.
AU - Utkin, Yu. N.
AU - Ermakov, Yuri A.
AU - Svirshchevskaya, E. V.
AU - Negrebetsky, Vadim V.
AU - Karpechenko, Natalia Yu
AU - Chernikov, Valery P.
AU - Onishchenko, Natalia R.
AU - Vodovozova, E. L.
AU - Schmalz, H.-G.
AU - Boldyrev, Ivan A
PY - 2019
DA - 2019/02/28
PB - American Chemical Society (ACS)
SP - 1098-1113
IS - 4
VL - 30
PMID - 30817133
SN - 1043-1802
SN - 1520-4812
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Shchegravina,
author = {Ekaterina S. Shchegravina and Daria S. Tretiakova and Anna Alekseeva and T. Galimzyanov and Yu. N. Utkin and Yuri A. Ermakov and E. V. Svirshchevskaya and Vadim V. Negrebetsky and Natalia Yu Karpechenko and Valery P. Chernikov and Natalia R. Onishchenko and E. L. Vodovozova and H.-G. Schmalz and Ivan A Boldyrev},
title = {Phospholipidic Colchicinoids as Promising Prodrugs Incorporated into Enzyme-Responsive Liposomes: Chemical, Biophysical, and Enzymological Aspects},
journal = {Bioconjugate Chemistry},
year = {2019},
volume = {30},
publisher = {American Chemical Society (ACS)},
month = {feb},
url = {https://doi.org/10.1021/acs.bioconjchem.9b00051},
number = {4},
pages = {1098--1113},
doi = {10.1021/acs.bioconjchem.9b00051}
}
Cite this
MLA
Copy
Shchegravina, Ekaterina S., et al. âPhospholipidic Colchicinoids as Promising Prodrugs Incorporated into Enzyme-Responsive Liposomes: Chemical, Biophysical, and Enzymological Aspects.â Bioconjugate Chemistry, vol. 30, no. 4, Feb. 2019, pp. 1098-1113. https://doi.org/10.1021/acs.bioconjchem.9b00051.