Three Polymorphic Forms of Ciprofloxacin Maleate: Formation Pathways, Crystal Structures, Calculations, and Thermodynamic Stability Aspects
Publication type: Journal Article
Publication date: 2016-10-17
scimago Q2
wos Q1
SJR: 0.633
CiteScore: 5.6
Impact factor: 3.4
ISSN: 15287483, 15287505
General Chemistry
Condensed Matter Physics
General Materials Science
Abstract
Polymorphism of the pharmaceutical salt of ciprofloxacin with maleic acid has been investigated. Ciprofloxacin maleate was found to exist in three polymorphic forms and one hydrate. The formation pathways of the salt polymorphs were elucidated by using solvent screening of the mechanochemical synthesis. It has been found that the mechanochemical reaction of the salt formation consists of two steps, including the formation of a kinetic polymorph as a transitional stage and its conversion into a thermodynamically favorable form. The thermodynamic relationships between the polymorphs were rationalized based on solubility and solution calorimetry measurements. The pattern of intermolecular interactions and crystal lattice energies of the polymorphs were quantified by solid-state density functional theory followed by Bader analysis of periodic electron density.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
5
6
|
|
|
Crystal Growth and Design
6 publications, 25%
|
|
|
CrystEngComm
4 publications, 16.67%
|
|
|
New Journal of Chemistry
2 publications, 8.33%
|
|
|
Pharmaceutics
2 publications, 8.33%
|
|
|
Physical Chemistry Chemical Physics
1 publication, 4.17%
|
|
|
Molecules
1 publication, 4.17%
|
|
|
Symmetry
1 publication, 4.17%
|
|
|
Russian Chemical Reviews
1 publication, 4.17%
|
|
|
Inorganic Chemistry Communication
1 publication, 4.17%
|
|
|
Journal of Pharmaceutical and Biomedical Analysis
1 publication, 4.17%
|
|
|
Crystal Research and Technology
1 publication, 4.17%
|
|
|
Industrial & Engineering Chemistry Research
1 publication, 4.17%
|
|
|
Green Chemistry
1 publication, 4.17%
|
|
|
Safety and Risk of Pharmacotherapy
1 publication, 4.17%
|
|
|
1
2
3
4
5
6
|
Publishers
|
1
2
3
4
5
6
7
8
|
|
|
Royal Society of Chemistry (RSC)
8 publications, 33.33%
|
|
|
American Chemical Society (ACS)
7 publications, 29.17%
|
|
|
MDPI
4 publications, 16.67%
|
|
|
Elsevier
2 publications, 8.33%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 4.17%
|
|
|
Wiley
1 publication, 4.17%
|
|
|
SCEEMP
1 publication, 4.17%
|
|
|
1
2
3
4
5
6
7
8
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
24
Total citations:
24
Citations from 2024:
2
(8.33%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Surov A. O. et al. Three Polymorphic Forms of Ciprofloxacin Maleate: Formation Pathways, Crystal Structures, Calculations, and Thermodynamic Stability Aspects // Crystal Growth and Design. 2016. Vol. 16. No. 11. pp. 6556-6567.
GOST all authors (up to 50)
Copy
Surov A. O., Churakov A. V., Perlovich G., PERLOVICH G. L. Three Polymorphic Forms of Ciprofloxacin Maleate: Formation Pathways, Crystal Structures, Calculations, and Thermodynamic Stability Aspects // Crystal Growth and Design. 2016. Vol. 16. No. 11. pp. 6556-6567.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.cgd.6b01277
UR - https://pubs.acs.org/doi/10.1021/acs.cgd.6b01277
TI - Three Polymorphic Forms of Ciprofloxacin Maleate: Formation Pathways, Crystal Structures, Calculations, and Thermodynamic Stability Aspects
T2 - Crystal Growth and Design
AU - Surov, Artem O
AU - Churakov, Andrei V.
AU - Perlovich, German
AU - PERLOVICH, GERMAN L.
PY - 2016
DA - 2016/10/17
PB - American Chemical Society (ACS)
SP - 6556-6567
IS - 11
VL - 16
SN - 1528-7483
SN - 1528-7505
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Surov,
author = {Artem O Surov and Andrei V. Churakov and German Perlovich and GERMAN L. PERLOVICH},
title = {Three Polymorphic Forms of Ciprofloxacin Maleate: Formation Pathways, Crystal Structures, Calculations, and Thermodynamic Stability Aspects},
journal = {Crystal Growth and Design},
year = {2016},
volume = {16},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://pubs.acs.org/doi/10.1021/acs.cgd.6b01277},
number = {11},
pages = {6556--6567},
doi = {10.1021/acs.cgd.6b01277}
}
Cite this
MLA
Copy
Surov, Artem O., et al. “Three Polymorphic Forms of Ciprofloxacin Maleate: Formation Pathways, Crystal Structures, Calculations, and Thermodynamic Stability Aspects.” Crystal Growth and Design, vol. 16, no. 11, Oct. 2016, pp. 6556-6567. https://pubs.acs.org/doi/10.1021/acs.cgd.6b01277.
Profiles