Weak Interactions Cause Packing Polymorphism in Pharmaceutical Two-Component Crystals. the Case Study of the Salicylamide Cocrystal
Artem O Surov
1
,
Alex N Manin
1
,
Alexander P. Voronin
2
,
German Perlovich
1
,
GERMAN L. PERLOVICH
2
,
Publication type: Journal Article
Publication date: 2017-02-13
scimago Q2
wos Q1
SJR: 0.633
CiteScore: 5.6
Impact factor: 3.4
ISSN: 15287483, 15287505
General Chemistry
Condensed Matter Physics
General Materials Science
Abstract
Two polymorphs of the salicylamide cocrystal with oxalic acid have been obtained and described. Form I of the cocrystal was prepared by three alternative methods in various solvents, while formation of form II was achieved only by a special crystallization procedure. Single-crystal X-ray analysis has revealed that polymorphs consist of conformationally identical salicylamide and oxalic acid molecules, which are assembled into supramolecular units connected via a network of very similar hydrogen bonds. The packing arrangements of the cocrystal polymorphs, however, were found to be different, suggesting a rare example of packing polymorphism. The stability relationship between the polymorphs has been rationalized by using a number of experimental methods, including thermochemical analysis, solubility, and solution calorimetry measurements. Similarities and differences in intermolecular contacts across two polymorphs have been visualized using the Hirshfeld surface analysis. The Bader analysis of the theoret...
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Total citations:
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Citations from 2024:
9
(21.42%)
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GOST
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Surov A. O. et al. Weak Interactions Cause Packing Polymorphism in Pharmaceutical Two-Component Crystals. the Case Study of the Salicylamide Cocrystal // Crystal Growth and Design. 2017. Vol. 17. No. 3. pp. 1425-1437.
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Surov A. O., Manin A. N., Voronin A., Voronin A. P., Churakov A. V., Perlovich G., PERLOVICH G. L., Vener M. V. Weak Interactions Cause Packing Polymorphism in Pharmaceutical Two-Component Crystals. the Case Study of the Salicylamide Cocrystal // Crystal Growth and Design. 2017. Vol. 17. No. 3. pp. 1425-1437.
Cite this
RIS
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TY - JOUR
DO - 10.1021/acs.cgd.7b00019
UR - https://pubs.acs.org/doi/10.1021/acs.cgd.7b00019
TI - Weak Interactions Cause Packing Polymorphism in Pharmaceutical Two-Component Crystals. the Case Study of the Salicylamide Cocrystal
T2 - Crystal Growth and Design
AU - Surov, Artem O
AU - Manin, Alex N
AU - Voronin, Alexander
AU - Voronin, Alexander P.
AU - Churakov, Andrei V.
AU - Perlovich, German
AU - PERLOVICH, GERMAN L.
AU - Vener, Mikhail V.
PY - 2017
DA - 2017/02/13
PB - American Chemical Society (ACS)
SP - 1425-1437
IS - 3
VL - 17
SN - 1528-7483
SN - 1528-7505
ER -
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@article{2017_Surov,
author = {Artem O Surov and Alex N Manin and Alexander Voronin and Alexander P. Voronin and Andrei V. Churakov and German Perlovich and GERMAN L. PERLOVICH and Mikhail V. Vener},
title = {Weak Interactions Cause Packing Polymorphism in Pharmaceutical Two-Component Crystals. the Case Study of the Salicylamide Cocrystal},
journal = {Crystal Growth and Design},
year = {2017},
volume = {17},
publisher = {American Chemical Society (ACS)},
month = {feb},
url = {https://pubs.acs.org/doi/10.1021/acs.cgd.7b00019},
number = {3},
pages = {1425--1437},
doi = {10.1021/acs.cgd.7b00019}
}
Cite this
MLA
Copy
Surov, Artem O., et al. “Weak Interactions Cause Packing Polymorphism in Pharmaceutical Two-Component Crystals. the Case Study of the Salicylamide Cocrystal.” Crystal Growth and Design, vol. 17, no. 3, Feb. 2017, pp. 1425-1437. https://pubs.acs.org/doi/10.1021/acs.cgd.7b00019.