Multidrug Cocrystal of Anticonvulsants: Influence of Strong Intermolecular Interactions on Physiochemical Properties
Publication type: Journal Article
Publication date: 2017-09-08
scimago Q2
wos Q1
SJR: 0.633
CiteScore: 5.6
Impact factor: 3.4
ISSN: 15287483, 15287505
PubMed ID:
31537980
General Chemistry
Condensed Matter Physics
General Materials Science
Abstract
A drug-drug cocrystal of two anticonvulsants, lamotrigine and phenobarbital, is presented. In the crystal structure, molecules form heterodimers via N-H···O and N-H···N hydrogen bonding. The intrinsic dissolution rate (IDR) and solubility of the cocrystal were measured in phosphate buffer (pH 7.2) and simulated gastric fluid (without pepsin), and compared to pure APIs. Dissolution experiments found suppressed IDR of the cocrystal with rates in the order pure PB > pure LTG > cocrystal. The solubility measurements were consistent with the dissolution behavior. The presence of strong heterodimers in the cocrystal compared to weaker homodimers in the parent drugs is implicated for the reduced solubility and dissolution rate.
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60
Total citations:
60
Citations from 2024:
8
(13%)
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MLA
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GOST
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Kaur R. et al. Multidrug Cocrystal of Anticonvulsants: Influence of Strong Intermolecular Interactions on Physiochemical Properties // Crystal Growth and Design. 2017. Vol. 17. No. 10. pp. 5012-5016.
GOST all authors (up to 50)
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Kaur R., Cavanagh K. L., Rodríguez‐Hornedo N., Matzger A. J. Multidrug Cocrystal of Anticonvulsants: Influence of Strong Intermolecular Interactions on Physiochemical Properties // Crystal Growth and Design. 2017. Vol. 17. No. 10. pp. 5012-5016.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.cgd.7b00741
UR - https://doi.org/10.1021/acs.cgd.7b00741
TI - Multidrug Cocrystal of Anticonvulsants: Influence of Strong Intermolecular Interactions on Physiochemical Properties
T2 - Crystal Growth and Design
AU - Kaur, Ramanpreet
AU - Cavanagh, Katie L.
AU - Rodríguez‐Hornedo, N.
AU - Matzger, Adam J.
PY - 2017
DA - 2017/09/08
PB - American Chemical Society (ACS)
SP - 5012-5016
IS - 10
VL - 17
PMID - 31537980
SN - 1528-7483
SN - 1528-7505
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2017_Kaur,
author = {Ramanpreet Kaur and Katie L. Cavanagh and N. Rodríguez‐Hornedo and Adam J. Matzger},
title = {Multidrug Cocrystal of Anticonvulsants: Influence of Strong Intermolecular Interactions on Physiochemical Properties},
journal = {Crystal Growth and Design},
year = {2017},
volume = {17},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021/acs.cgd.7b00741},
number = {10},
pages = {5012--5016},
doi = {10.1021/acs.cgd.7b00741}
}
Cite this
MLA
Copy
Kaur, Ramanpreet, et al. “Multidrug Cocrystal of Anticonvulsants: Influence of Strong Intermolecular Interactions on Physiochemical Properties.” Crystal Growth and Design, vol. 17, no. 10, Sep. 2017, pp. 5012-5016. https://doi.org/10.1021/acs.cgd.7b00741.
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