Multidrug Cocrystal of Anticonvulsants: Influence of Strong Intermolecular Interactions on Physiochemical Properties
Тип публикации: Journal Article
Дата публикации: 2017-09-08
scimago Q2
wos Q1
БС1
SJR: 0.633
CiteScore: 5.6
Impact factor: 3.4
ISSN: 15287483, 15287505
PubMed ID:
31537980
General Chemistry
Condensed Matter Physics
General Materials Science
Краткое описание
A drug-drug cocrystal of two anticonvulsants, lamotrigine and phenobarbital, is presented. In the crystal structure, molecules form heterodimers via N-H···O and N-H···N hydrogen bonding. The intrinsic dissolution rate (IDR) and solubility of the cocrystal were measured in phosphate buffer (pH 7.2) and simulated gastric fluid (without pepsin), and compared to pure APIs. Dissolution experiments found suppressed IDR of the cocrystal with rates in the order pure PB > pure LTG > cocrystal. The solubility measurements were consistent with the dissolution behavior. The presence of strong heterodimers in the cocrystal compared to weaker homodimers in the parent drugs is implicated for the reduced solubility and dissolution rate.
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Kaur R. et al. Multidrug Cocrystal of Anticonvulsants: Influence of Strong Intermolecular Interactions on Physiochemical Properties // Crystal Growth and Design. 2017. Vol. 17. No. 10. pp. 5012-5016.
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Kaur R., Cavanagh K. L., Rodríguez‐Hornedo N., Matzger A. J. Multidrug Cocrystal of Anticonvulsants: Influence of Strong Intermolecular Interactions on Physiochemical Properties // Crystal Growth and Design. 2017. Vol. 17. No. 10. pp. 5012-5016.
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TY - JOUR
DO - 10.1021/acs.cgd.7b00741
UR - https://doi.org/10.1021/acs.cgd.7b00741
TI - Multidrug Cocrystal of Anticonvulsants: Influence of Strong Intermolecular Interactions on Physiochemical Properties
T2 - Crystal Growth and Design
AU - Kaur, Ramanpreet
AU - Cavanagh, Katie L.
AU - Rodríguez‐Hornedo, N.
AU - Matzger, Adam J.
PY - 2017
DA - 2017/09/08
PB - American Chemical Society (ACS)
SP - 5012-5016
IS - 10
VL - 17
PMID - 31537980
SN - 1528-7483
SN - 1528-7505
ER -
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@article{2017_Kaur,
author = {Ramanpreet Kaur and Katie L. Cavanagh and N. Rodríguez‐Hornedo and Adam J. Matzger},
title = {Multidrug Cocrystal of Anticonvulsants: Influence of Strong Intermolecular Interactions on Physiochemical Properties},
journal = {Crystal Growth and Design},
year = {2017},
volume = {17},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021/acs.cgd.7b00741},
number = {10},
pages = {5012--5016},
doi = {10.1021/acs.cgd.7b00741}
}
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MLA
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Kaur, Ramanpreet, et al. “Multidrug Cocrystal of Anticonvulsants: Influence of Strong Intermolecular Interactions on Physiochemical Properties.” Crystal Growth and Design, vol. 17, no. 10, Sep. 2017, pp. 5012-5016. https://doi.org/10.1021/acs.cgd.7b00741.