volume 18 issue 4 pages 2297-2304

Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology

Publication typeJournal Article
Publication date2018-03-13
scimago Q2
wos Q1
SJR0.633
CiteScore5.6
Impact factor3.4
ISSN15287483, 15287505
General Chemistry
Condensed Matter Physics
General Materials Science
Abstract
Solid state shear milling (S3M) is reported as a scalable, continuous, polymer-assisted cocrystallization technique. A specially designed milling pan was employed to provide high levels of applied shear, and the addition of a polymeric processing aid enabled generation of high stress fields. Carbamazepine–salicylic acid cocrystals were produced with 5–25 wt % of poly(ethylene oxide) (PEO). A systematic study was carried out to understand the effect of process variables on properties and performance of the cocrystals. S3M offers an important new route for continuous manufacturing of pharmaceutical cocrystals.
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GOST |
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GOST Copy
Korde S. et al. Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology // Crystal Growth and Design. 2018. Vol. 18. No. 4. pp. 2297-2304.
GOST all authors (up to 50) Copy
He P., Chen Y., Wang Q. Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology // Crystal Growth and Design. 2018. Vol. 18. No. 4. pp. 2297-2304.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1021/acs.cgd.7b01733
UR - https://doi.org/10.1021/acs.cgd.7b01733
TI - Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology
T2 - Crystal Growth and Design
AU - He, Pan
AU - Chen, Yinghong
AU - Wang, Qi
PY - 2018
DA - 2018/03/13
PB - American Chemical Society (ACS)
SP - 2297-2304
IS - 4
VL - 18
SN - 1528-7483
SN - 1528-7505
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2018_Korde,
author = {Pan He and Yinghong Chen and Qi Wang},
title = {Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology},
journal = {Crystal Growth and Design},
year = {2018},
volume = {18},
publisher = {American Chemical Society (ACS)},
month = {mar},
url = {https://doi.org/10.1021/acs.cgd.7b01733},
number = {4},
pages = {2297--2304},
doi = {10.1021/acs.cgd.7b01733}
}
MLA
Cite this
MLA Copy
Korde, Sachin, et al. “Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology.” Crystal Growth and Design, vol. 18, no. 4, Mar. 2018, pp. 2297-2304. https://doi.org/10.1021/acs.cgd.7b01733.