Drug-Bridge-Drug Ternary Cocrystallization Strategy for Antituberculosis Drugs Combination
1
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong 266003, PR China
|
Publication type: Journal Article
Publication date: 2018-01-23
scimago Q2
wos Q1
SJR: 0.633
CiteScore: 5.6
Impact factor: 3.4
ISSN: 15287483, 15287505
General Chemistry
Condensed Matter Physics
General Materials Science
Abstract
Realizing combination drugs at a molecular level via drug–drug cocrystallization opens a new pathway for effective therapeutic hybrids. A “drug-bridge-drug” strategy is developed to cocrystallize two first-line antitubercular drugs isoniazid and pyrazinamide using fumaric acid as the bridge, overcoming the issue of hardly cocrystallizing two different drugs. The first example of ternary cocrystal with combination drugs exhibits optimized formulation capacity and in vitro/vivo synergistic effects, which provides a new insight into antituberculosis combination drugs.
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Metrics
72
Total citations:
72
Citations from 2025:
2
(2.78%)
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GOST
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Song Yu. et al. Drug-Bridge-Drug Ternary Cocrystallization Strategy for Antituberculosis Drugs Combination // Crystal Growth and Design. 2018. Vol. 18. No. 3. pp. 1283-1286.
GOST all authors (up to 50)
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LI Y. Drug-Bridge-Drug Ternary Cocrystallization Strategy for Antituberculosis Drugs Combination // Crystal Growth and Design. 2018. Vol. 18. No. 3. pp. 1283-1286.
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RIS
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TY - JOUR
DO - 10.1021/acs.cgd.7b01738
UR - https://doi.org/10.1021/acs.cgd.7b01738
TI - Drug-Bridge-Drug Ternary Cocrystallization Strategy for Antituberculosis Drugs Combination
T2 - Crystal Growth and Design
AU - LI, YAN-TUAN
PY - 2018
DA - 2018/01/23
PB - American Chemical Society (ACS)
SP - 1283-1286
IS - 3
VL - 18
SN - 1528-7483
SN - 1528-7505
ER -
Cite this
BibTex (up to 50 authors)
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@article{2018_Song,
author = {YAN-TUAN LI},
title = {Drug-Bridge-Drug Ternary Cocrystallization Strategy for Antituberculosis Drugs Combination},
journal = {Crystal Growth and Design},
year = {2018},
volume = {18},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/acs.cgd.7b01738},
number = {3},
pages = {1283--1286},
doi = {10.1021/acs.cgd.7b01738}
}
Cite this
MLA
Copy
Song, Yu., et al. “Drug-Bridge-Drug Ternary Cocrystallization Strategy for Antituberculosis Drugs Combination.” Crystal Growth and Design, vol. 18, no. 3, Jan. 2018, pp. 1283-1286. https://doi.org/10.1021/acs.cgd.7b01738.