Cryosynthesis of Co-Crystals of Poorly Water-Soluble Pharmaceutical Compounds and Their Solid Dispersions with Polymers. The “Meloxicam–Succinic Acid” System as a Case Study
Andrey G Ogienko
1
,
Svetlana A Myz
1, 2
,
Anna A Ogienko
1
,
Andrey A Nefedov
1
,
Andrey S Stoporev
1, 3
,
Maxim S Melgunov
1
,
Alexander S Yunoshev
1
,
Tatyana P. Shakhtshneider
1, 2
,
Vladimir V. Boldyrev
1, 2
,
Publication type: Journal Article
Publication date: 2018-11-01
scimago Q2
wos Q1
SJR: 0.633
CiteScore: 5.6
Impact factor: 3.4
ISSN: 15287483, 15287505
General Chemistry
Condensed Matter Physics
General Materials Science
Abstract
Co-crystals of pharmaceutical compounds are widely used to improve the properties of drug formulations, such as dissolution behavior, bioavailability, or tabletability. The main methods of their synthesis include co-crystallization from solution, melt, or cogrinding. Only a few examples have been documented when co-crystals have been obtained by freeze-drying, namely, in systems where the components of a target co-crystal had similar aqueous solubilities. This work illustrates the potential of freeze-drying for obtaining pharmaceutical cocrystals when the solubilities of individual components differ drastically. Co-crystals of a model system—meloxicam and succinic acid—could be obtained both as a pure crystalline phase and forming a solid dispersion with a polymeric carrier. We show that even for pharmaceutical compounds with very low aqueous solubility, co-crystals with well-soluble coformers can be successfully produced under well-optimized conditions of cooling and subsequent freeze-drying. The rate of...
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Ogienko A. G. et al. Cryosynthesis of Co-Crystals of Poorly Water-Soluble Pharmaceutical Compounds and Their Solid Dispersions with Polymers. The “Meloxicam–Succinic Acid” System as a Case Study // Crystal Growth and Design. 2018. Vol. 18. No. 12. pp. 7401-7409.
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Ogienko A. G., Myz S. A., Ogienko A. A., Nefedov A. A., Stoporev A. S., Melgunov M. S., Yunoshev A. S., Shakhtshneider T. P., Boldyrev V. V., Boldyreva E. Cryosynthesis of Co-Crystals of Poorly Water-Soluble Pharmaceutical Compounds and Their Solid Dispersions with Polymers. The “Meloxicam–Succinic Acid” System as a Case Study // Crystal Growth and Design. 2018. Vol. 18. No. 12. pp. 7401-7409.
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RIS
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TY - JOUR
DO - 10.1021/acs.cgd.8b01070
UR - https://doi.org/10.1021/acs.cgd.8b01070
TI - Cryosynthesis of Co-Crystals of Poorly Water-Soluble Pharmaceutical Compounds and Their Solid Dispersions with Polymers. The “Meloxicam–Succinic Acid” System as a Case Study
T2 - Crystal Growth and Design
AU - Ogienko, Andrey G
AU - Myz, Svetlana A
AU - Ogienko, Anna A
AU - Nefedov, Andrey A
AU - Stoporev, Andrey S
AU - Melgunov, Maxim S
AU - Yunoshev, Alexander S
AU - Shakhtshneider, Tatyana P.
AU - Boldyrev, Vladimir V.
AU - Boldyreva, Elena
PY - 2018
DA - 2018/11/01
PB - American Chemical Society (ACS)
SP - 7401-7409
IS - 12
VL - 18
SN - 1528-7483
SN - 1528-7505
ER -
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BibTex (up to 50 authors)
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@article{2018_Ogienko,
author = {Andrey G Ogienko and Svetlana A Myz and Anna A Ogienko and Andrey A Nefedov and Andrey S Stoporev and Maxim S Melgunov and Alexander S Yunoshev and Tatyana P. Shakhtshneider and Vladimir V. Boldyrev and Elena Boldyreva},
title = {Cryosynthesis of Co-Crystals of Poorly Water-Soluble Pharmaceutical Compounds and Their Solid Dispersions with Polymers. The “Meloxicam–Succinic Acid” System as a Case Study},
journal = {Crystal Growth and Design},
year = {2018},
volume = {18},
publisher = {American Chemical Society (ACS)},
month = {nov},
url = {https://doi.org/10.1021/acs.cgd.8b01070},
number = {12},
pages = {7401--7409},
doi = {10.1021/acs.cgd.8b01070}
}
Cite this
MLA
Copy
Ogienko, Andrey G., et al. “Cryosynthesis of Co-Crystals of Poorly Water-Soluble Pharmaceutical Compounds and Their Solid Dispersions with Polymers. The “Meloxicam–Succinic Acid” System as a Case Study.” Crystal Growth and Design, vol. 18, no. 12, Nov. 2018, pp. 7401-7409. https://doi.org/10.1021/acs.cgd.8b01070.