Label-Free and Selective Single-Molecule Bioelectronic Sensing with a Millimeter-Wide Self-Assembled Monolayer of Anti-Immunoglobulins
Eleonora Macchia
1
,
Amber Tiwari
1
,
Kyriaki Manoli
1
,
Brigitte Holzer
1
,
Nicoletta Ditaranto
1
,
Rosaria Anna Picca
1
,
N. Cioffi
1
,
Cinzia Di Franco
2
,
Gaetano Scamarcio
2, 3
,
Gerardo Palazzo
1, 4
,
L. Torsi
1, 4
3
Publication type: Journal Article
Publication date: 2019-01-02
scimago Q1
wos Q1
SJR: 2.065
CiteScore: 12.0
Impact factor: 7.0
ISSN: 08974756, 15205002
Materials Chemistry
General Chemistry
General Chemical Engineering
Abstract
Immunoglobulin M (IgM) single-molecule and label-free detection is demonstrated, for the first time, by means of an electrolyte-gated thin-film transistor. The sensor integrates a millimeter-wide self-assembled monolayer (SAM) that includes trillions of anti-IgM capturing proteins. This adds generality to the already introduced single molecule with a transistor (SiMoT) platform. Besides the extremely high sensitivity, the SAM confers to the SiMoT bioelectronic sensor a high selectivity that is here assessed by measuring the differential responses of the IgM or the immunoglobulin G (IgG) cognate biomarkers mutually interacting with anti-IgM or anti-IgG capturing SAMs. At the same time, no response to IgG or IgM is measured with the anti-IgM or anti-IgG SAM, respectively. The SiMoT technology is known to exploit the hydrogen bonding network present in the SAM. In this paper, further elements supporting the model of this network enabling single-molecule sensitivity are provided by demonstrating that, once th...
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74
Total citations:
74
Citations from 2024:
20
(27.02%)
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GOST
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Macchia E. et al. Label-Free and Selective Single-Molecule Bioelectronic Sensing with a Millimeter-Wide Self-Assembled Monolayer of Anti-Immunoglobulins // Chemistry of Materials. 2019. Vol. 31. No. 17. pp. 6476-6483.
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Macchia E., Tiwari A., Manoli K., Holzer B., Ditaranto N., Picca R. A., Cioffi N., Di Franco C., Scamarcio G., Palazzo G., Torsi L. Label-Free and Selective Single-Molecule Bioelectronic Sensing with a Millimeter-Wide Self-Assembled Monolayer of Anti-Immunoglobulins // Chemistry of Materials. 2019. Vol. 31. No. 17. pp. 6476-6483.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.chemmater.8b04414
UR - https://doi.org/10.1021/acs.chemmater.8b04414
TI - Label-Free and Selective Single-Molecule Bioelectronic Sensing with a Millimeter-Wide Self-Assembled Monolayer of Anti-Immunoglobulins
T2 - Chemistry of Materials
AU - Macchia, Eleonora
AU - Tiwari, Amber
AU - Manoli, Kyriaki
AU - Holzer, Brigitte
AU - Ditaranto, Nicoletta
AU - Picca, Rosaria Anna
AU - Cioffi, N.
AU - Di Franco, Cinzia
AU - Scamarcio, Gaetano
AU - Palazzo, Gerardo
AU - Torsi, L.
PY - 2019
DA - 2019/01/02
PB - American Chemical Society (ACS)
SP - 6476-6483
IS - 17
VL - 31
SN - 0897-4756
SN - 1520-5002
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Macchia,
author = {Eleonora Macchia and Amber Tiwari and Kyriaki Manoli and Brigitte Holzer and Nicoletta Ditaranto and Rosaria Anna Picca and N. Cioffi and Cinzia Di Franco and Gaetano Scamarcio and Gerardo Palazzo and L. Torsi},
title = {Label-Free and Selective Single-Molecule Bioelectronic Sensing with a Millimeter-Wide Self-Assembled Monolayer of Anti-Immunoglobulins},
journal = {Chemistry of Materials},
year = {2019},
volume = {31},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/acs.chemmater.8b04414},
number = {17},
pages = {6476--6483},
doi = {10.1021/acs.chemmater.8b04414}
}
Cite this
MLA
Copy
Macchia, Eleonora, et al. “Label-Free and Selective Single-Molecule Bioelectronic Sensing with a Millimeter-Wide Self-Assembled Monolayer of Anti-Immunoglobulins.” Chemistry of Materials, vol. 31, no. 17, Jan. 2019, pp. 6476-6483. https://doi.org/10.1021/acs.chemmater.8b04414.