Chelating Phosphine–N-Heterocyclic Carbene Platinum Complexes via Catalytic Asymmetric Hydrophosphination and Their Cytotoxicity Toward MKN74 and MCF7 Cancer Cell Lines
Jeffery Wee Kiong Seah
1
,
Jeannie Xue Ting Lee
2
,
Yongxin Li
1
,
Sumod A. Pullarkat
1
,
Nguan Soon Tan
2, 3
,
Pak-Hing Leung
1
Publication type: Journal Article
Publication date: 2021-10-28
scimago Q1
wos Q1
SJR: 0.958
CiteScore: 7.4
Impact factor: 4.7
ISSN: 00201669, 1520510X
PubMed ID:
34709031
Inorganic Chemistry
Physical and Theoretical Chemistry
Abstract
A series of activated vinyl azoles was hydrophosphinated in the presence of a chiral palladacycle catalyst under mild conditions to give enantioenriched phosphine azoles with moderate enantioselectivities and yields. The racemic phosphine azoles were transformed into eleven novel chelating phosphine-N-heterocyclic carbene (NHC) platinum complexes. The drug efficacies of nine selected phosphine-NHC platinum(II) chlorides in two cancer cell lines (MKN74 and MCF7) were evaluated, and two were found to exhibit activities comparable to that of cisplatin.
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11
Total citations:
11
Citations from 2025:
3
(27.27%)
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GOST
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Seah J. W. K. et al. Chelating Phosphine–N-Heterocyclic Carbene Platinum Complexes via Catalytic Asymmetric Hydrophosphination and Their Cytotoxicity Toward MKN74 and MCF7 Cancer Cell Lines // Inorganic Chemistry. 2021. Vol. 60. No. 22. pp. 17276-17287.
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Seah J. W. K., Lee J. X. T., Li Y., Pullarkat S. A., Tan N. S., Leung P. Chelating Phosphine–N-Heterocyclic Carbene Platinum Complexes via Catalytic Asymmetric Hydrophosphination and Their Cytotoxicity Toward MKN74 and MCF7 Cancer Cell Lines // Inorganic Chemistry. 2021. Vol. 60. No. 22. pp. 17276-17287.
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RIS
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TY - JOUR
DO - 10.1021/acs.inorgchem.1c02625
UR - https://doi.org/10.1021/acs.inorgchem.1c02625
TI - Chelating Phosphine–N-Heterocyclic Carbene Platinum Complexes via Catalytic Asymmetric Hydrophosphination and Their Cytotoxicity Toward MKN74 and MCF7 Cancer Cell Lines
T2 - Inorganic Chemistry
AU - Seah, Jeffery Wee Kiong
AU - Lee, Jeannie Xue Ting
AU - Li, Yongxin
AU - Pullarkat, Sumod A.
AU - Tan, Nguan Soon
AU - Leung, Pak-Hing
PY - 2021
DA - 2021/10/28
PB - American Chemical Society (ACS)
SP - 17276-17287
IS - 22
VL - 60
PMID - 34709031
SN - 0020-1669
SN - 1520-510X
ER -
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BibTex (up to 50 authors)
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@article{2021_Seah,
author = {Jeffery Wee Kiong Seah and Jeannie Xue Ting Lee and Yongxin Li and Sumod A. Pullarkat and Nguan Soon Tan and Pak-Hing Leung},
title = {Chelating Phosphine–N-Heterocyclic Carbene Platinum Complexes via Catalytic Asymmetric Hydrophosphination and Their Cytotoxicity Toward MKN74 and MCF7 Cancer Cell Lines},
journal = {Inorganic Chemistry},
year = {2021},
volume = {60},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/acs.inorgchem.1c02625},
number = {22},
pages = {17276--17287},
doi = {10.1021/acs.inorgchem.1c02625}
}
Cite this
MLA
Copy
Seah, Jeffery Wee Kiong, et al. “Chelating Phosphine–N-Heterocyclic Carbene Platinum Complexes via Catalytic Asymmetric Hydrophosphination and Their Cytotoxicity Toward MKN74 and MCF7 Cancer Cell Lines.” Inorganic Chemistry, vol. 60, no. 22, Oct. 2021, pp. 17276-17287. https://doi.org/10.1021/acs.inorgchem.1c02625.