Inorganic Chemistry, volume 56, issue 20, pages 12232-12247

Anticancer Activity of Iridium(III) Complexes Based on a Pyrazole-Appended Quinoline-Based BODIPY.

Paitandi Rajendra Prasad ¹

Mukhopadhyay Sujay ¹

Singh Roop ¹

Sharma Vinay S.

Mobin Shaikh M.

Pandey Daya Shankar ¹

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Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India |

Publication type: Journal Article

Publication date: 2017-09-28

American Chemical Society (ACS)

Journal: Inorganic Chemistry

Quartile SCImago

Quartile WOS

Impact factor: 4.6

ISSN: 00201669, 1520510X

DOI: 10.1021/acs.inorgchem.7b01693

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Inorganic Chemistry

Physical and Theoretical Chemistry

Abstract

A pyrazole-appended quinoline-based 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (L1, BODIPY) has been synthesized and used as a ligand for the preparation of iridium(III) complexes [Ir(phpy)2(L1)]PF6 (1; phpy = 2-phenylpyridine) and [(η5-C5Me5)Ir(L1)Cl]PF6 (2). The ligand L1 and complexes 1 and 2 have been meticulously characterized by elemental analyses and spectral studies (IR, electrospray ionization mass spectrometry, 1H and 13C NMR, UV/vis, fluorescence) and their structures explicitly authenticated by single-crystal X-ray analyses. UV/vis, fluorescence, and circular dichroism studies showed that complexes strongly bind with calf-thymus DNA and bovine serum albumin. Molecular docking studies clearly illustrated binding through DNA minor grooves via van der Waals forces and their electrostatic interaction and occurrence in the hydrophobic cavity of protein (subdomain IIA). Cytotoxicity, morphological changes, and apoptosis have been explored by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and Hoechst 33342 staining. IC50 values for complexes (1, 30 μM; 2, 50 μM) at 24 h toward the human cervical cancer cell line (HeLa) are as good as that of cisplatin (21.6 μM) under analogous conditions, and their ability to kill cancer cells lies in the order 1 > 2. Because of the inherent emissive nature of the BODIPY moiety, these are apt for intracellular visualization at low concentration and may find potential applications in cellular imaging and behave as a theranostic agent.

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Wiley	Wiley, 5, 7.35% Wiley 5 publications, 7.35%
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Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 1, 1.47% Multidisciplinary Digital Publishing Institute (MDPI) 1 publication, 1.47%
Springer Nature	Springer Nature, 1, 1.47% Springer Nature 1 publication, 1.47%
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Paitandi R. P. et al. Anticancer Activity of Iridium(III) Complexes Based on a Pyrazole-Appended Quinoline-Based BODIPY. // Inorganic Chemistry. 2017. Vol. 56. No. 20. pp. 12232-12247.

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Paitandi R. P., Mukhopadhyay S., Singh R., Sharma V. S., Mobin S. M., Pandey D. S. Anticancer Activity of Iridium(III) Complexes Based on a Pyrazole-Appended Quinoline-Based BODIPY. // Inorganic Chemistry. 2017. Vol. 56. No. 20. pp. 12232-12247.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/acs.inorgchem.7b01693

UR - https://doi.org/10.1021%2Facs.inorgchem.7b01693

TI - Anticancer Activity of Iridium(III) Complexes Based on a Pyrazole-Appended Quinoline-Based BODIPY.

T2 - Inorganic Chemistry

AU - Paitandi, Rajendra Prasad

AU - Mukhopadhyay, Sujay

AU - Mobin, Shaikh M.

AU - Pandey, Daya Shankar

AU - Singh, Roop

AU - Sharma, Vinay S.

PY - 2017

DA - 2017/09/28 00:00:00

PB - American Chemical Society (ACS)

SP - 12232-12247

IS - 20

VL - 56

SN - 0020-1669

SN - 1520-510X

ER -

BibTex |

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BibTex Copy

@article{2017_Paitandi,

author = {Rajendra Prasad Paitandi and Sujay Mukhopadhyay and Shaikh M. Mobin and Daya Shankar Pandey and Roop Singh and Vinay S. Sharma},

title = {Anticancer Activity of Iridium(III) Complexes Based on a Pyrazole-Appended Quinoline-Based BODIPY.},

journal = {Inorganic Chemistry},

year = {2017},

volume = {56},

publisher = {American Chemical Society (ACS)},

month = {sep},

url = {https://doi.org/10.1021%2Facs.inorgchem.7b01693},

number = {20},

pages = {12232--12247},

doi = {10.1021/acs.inorgchem.7b01693}

}

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Paitandi, Rajendra Prasad, et al. “Anticancer Activity of Iridium(III) Complexes Based on a Pyrazole-Appended Quinoline-Based BODIPY..” Inorganic Chemistry, vol. 56, no. 20, Sep. 2017, pp. 12232-12247. https://doi.org/10.1021%2Facs.inorgchem.7b01693.

Found error?

Publisher

American Chemical Society (ACS)

Journal

Inorganic Chemistry

Quartile SCImago

Quartile WOS

Impact factor

4.6

ISSN

00201669 (Print)
1520510X (Electronic)

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