Has Ferrocene Really Delivered Its Role in Accentuating the Bioactivity of Organic Scaffolds?
Publication type: Journal Article
Publication date: 2021-11-18
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
34792350
Drug Discovery
Molecular Medicine
Abstract
Ferrocene is an important structural core in bioorganometallic chemistry because of its inherent stability, excellent redox properties, and low toxicity. Ferroquine and ferrocifen are two of the most notable contributions of ferrocene to medicinal chemistry with remarkable antimalarial and anticancer properties. The improved medicinal properties of these drug candidates highlight the impact that ferrocene can have on the molecular and biological properties of the bioactive compounds. In this Perspective, we investigate the scope and limitations of ferrocene incorporation into organic compounds/natural products on their mode of action and biological activities. We have also discussed the detailed role of ferrocene modifications in influencing the anticancer, antimalarial, and antimicrobial properties of various bioactive moieties to design safer and promising ferrocene-based drugs.
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Metrics
126
Total citations:
126
Citations from 2025:
38
(30.16%)
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GOST
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Sharma B., Kumar V. Has Ferrocene Really Delivered Its Role in Accentuating the Bioactivity of Organic Scaffolds? // Journal of Medicinal Chemistry. 2021. Vol. 64. No. 23. pp. 16865-16921.
GOST all authors (up to 50)
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Sharma B., Kumar V. Has Ferrocene Really Delivered Its Role in Accentuating the Bioactivity of Organic Scaffolds? // Journal of Medicinal Chemistry. 2021. Vol. 64. No. 23. pp. 16865-16921.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.jmedchem.1c00390
UR - https://doi.org/10.1021/acs.jmedchem.1c00390
TI - Has Ferrocene Really Delivered Its Role in Accentuating the Bioactivity of Organic Scaffolds?
T2 - Journal of Medicinal Chemistry
AU - Sharma, Bharvi
AU - Kumar, Vipan
PY - 2021
DA - 2021/11/18
PB - American Chemical Society (ACS)
SP - 16865-16921
IS - 23
VL - 64
PMID - 34792350
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Sharma,
author = {Bharvi Sharma and Vipan Kumar},
title = {Has Ferrocene Really Delivered Its Role in Accentuating the Bioactivity of Organic Scaffolds?},
journal = {Journal of Medicinal Chemistry},
year = {2021},
volume = {64},
publisher = {American Chemical Society (ACS)},
month = {nov},
url = {https://doi.org/10.1021/acs.jmedchem.1c00390},
number = {23},
pages = {16865--16921},
doi = {10.1021/acs.jmedchem.1c00390}
}
Cite this
MLA
Copy
Sharma, Bharvi, and Vipan Kumar. “Has Ferrocene Really Delivered Its Role in Accentuating the Bioactivity of Organic Scaffolds?.” Journal of Medicinal Chemistry, vol. 64, no. 23, Nov. 2021, pp. 16865-16921. https://doi.org/10.1021/acs.jmedchem.1c00390.