A Smart Europium–Ruthenium Complex as Anticancer Prodrug: Controllable Drug Release and Real-Time Monitoring under Different Light Excitations
Hongguang Li
1
,
Chen Xie
1
,
Rongfeng Lan
1, 2
,
Shuai Zha
1
,
Chi-Fai Chan
1
,
Wing-Yan Wong
3
,
Ka-Lok Ho
1
,
Brandon W. Chan
3
,
Yuxia Luo
1
,
Jing Xiang Zhang
1, 4
,
Ga-Lai Law
3
,
William Chi-Shing Tai
3
,
Jean-Claude G. Bünzli
1, 5
,
Тип публикации: Journal Article
Дата публикации: 2017-10-19
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
28991460
Drug Discovery
Molecular Medicine
Краткое описание
A unique, dual-function, photoactivatable anticancer prodrug, RuEuL, has been tailored that features a ruthenium(II) complex linked to a cyclen-europium chelate via a π-conjugated bridge. Under irradiation at 488 nm, the dark-inactive prodrug undergoes photodissociation, releasing the DNA-damaging ruthenium species. Under evaluation-window irradiation (λirr = one-photon 350 nm or two-photon 700 nm), the drug delivery process can be quantitatively monitored in real-time because of the long-lived red europium emission. Linear relationships between released drug concentration and ESI-MS or luminescence responses are established. Finally, the efficiency of the new prodrug is demonstrated both in vitro RuEuL anticancer prodrug over some existing ones and open the way for decisive improvements in multipurpose prodrugs.
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MLA
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ГОСТ
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Li H. et al. A Smart Europium–Ruthenium Complex as Anticancer Prodrug: Controllable Drug Release and Real-Time Monitoring under Different Light Excitations // Journal of Medicinal Chemistry. 2017. Vol. 60. No. 21. pp. 8923-8932.
ГОСТ со всеми авторами (до 50)
Скопировать
Li H., Xie C., Lan R., Zha S., Chan C., Wong W., Ho K., Chan B. W., Luo Y., Zhang J. X., Law G., Tai W. C., Bünzli J. G., Wong K. A Smart Europium–Ruthenium Complex as Anticancer Prodrug: Controllable Drug Release and Real-Time Monitoring under Different Light Excitations // Journal of Medicinal Chemistry. 2017. Vol. 60. No. 21. pp. 8923-8932.
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RIS
Скопировать
TY - JOUR
DO - 10.1021/acs.jmedchem.7b01162
UR - https://doi.org/10.1021/acs.jmedchem.7b01162
TI - A Smart Europium–Ruthenium Complex as Anticancer Prodrug: Controllable Drug Release and Real-Time Monitoring under Different Light Excitations
T2 - Journal of Medicinal Chemistry
AU - Li, Hongguang
AU - Xie, Chen
AU - Lan, Rongfeng
AU - Zha, Shuai
AU - Chan, Chi-Fai
AU - Wong, Wing-Yan
AU - Ho, Ka-Lok
AU - Chan, Brandon W.
AU - Luo, Yuxia
AU - Zhang, Jing Xiang
AU - Law, Ga-Lai
AU - Tai, William Chi-Shing
AU - Bünzli, Jean-Claude G.
AU - Wong, Ka-Leung
PY - 2017
DA - 2017/10/19
PB - American Chemical Society (ACS)
SP - 8923-8932
IS - 21
VL - 60
PMID - 28991460
SN - 0022-2623
SN - 1520-4804
ER -
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BibTex (до 50 авторов)
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@article{2017_Li,
author = {Hongguang Li and Chen Xie and Rongfeng Lan and Shuai Zha and Chi-Fai Chan and Wing-Yan Wong and Ka-Lok Ho and Brandon W. Chan and Yuxia Luo and Jing Xiang Zhang and Ga-Lai Law and William Chi-Shing Tai and Jean-Claude G. Bünzli and Ka-Leung Wong},
title = {A Smart Europium–Ruthenium Complex as Anticancer Prodrug: Controllable Drug Release and Real-Time Monitoring under Different Light Excitations},
journal = {Journal of Medicinal Chemistry},
year = {2017},
volume = {60},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/acs.jmedchem.7b01162},
number = {21},
pages = {8923--8932},
doi = {10.1021/acs.jmedchem.7b01162}
}
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MLA
Скопировать
Li, Hongguang, et al. “A Smart Europium–Ruthenium Complex as Anticancer Prodrug: Controllable Drug Release and Real-Time Monitoring under Different Light Excitations.” Journal of Medicinal Chemistry, vol. 60, no. 21, Oct. 2017, pp. 8923-8932. https://doi.org/10.1021/acs.jmedchem.7b01162.