Reductive Cleavage of 4′H-Spiro[indole-3,5′-isoxazoles] En Route to 2-(1H-Indol-3-yl)acetamides with Anticancer Activities
Тип публикации: Journal Article
Дата публикации: 2022-10-19
scimago Q2
wos Q1
БС1
SJR: 0.737
CiteScore: 6.1
Impact factor: 3.6
ISSN: 00223263, 15206904
PubMed ID:
36260110
Organic Chemistry
Краткое описание
Unusual cascade transformation involving ring opening and 1,2-alkyl shift was observed upon the reduction of 4'H-spiro[indole-3,5'-isoxazoles] or 2-(3-oxoindolin-2-yl)acetonitriles with sodium borohydride. This reaction allowed for expeditious and highly efficient preparation of 2-(1H-Indol-3-yl)acetamides with antiproliferative properties.
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Aksenov A. et al. Reductive Cleavage of 4′H-Spiro[indole-3,5′-isoxazoles] En Route to 2-(1H-Indol-3-yl)acetamides with Anticancer Activities // Journal of Organic Chemistry. 2022. Vol. 87. No. 21. pp. 13955-13964.
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Aksenov A., Kirilov N. K., Arutiunov N. A., Aksenov D. A., Kuzminov I. K., Aksenov N. A., Turner D. N., Rogelj S., Kornienko A., Rubin M. Reductive Cleavage of 4′H-Spiro[indole-3,5′-isoxazoles] En Route to 2-(1H-Indol-3-yl)acetamides with Anticancer Activities // Journal of Organic Chemistry. 2022. Vol. 87. No. 21. pp. 13955-13964.
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TY - JOUR
DO - 10.1021/acs.joc.2c01627
UR - https://doi.org/10.1021/acs.joc.2c01627
TI - Reductive Cleavage of 4′H-Spiro[indole-3,5′-isoxazoles] En Route to 2-(1H-Indol-3-yl)acetamides with Anticancer Activities
T2 - Journal of Organic Chemistry
AU - Aksenov, Alexander V.
AU - Kirilov, Nikita K
AU - Arutiunov, Nikolai A
AU - Aksenov, Dmitrii A
AU - Kuzminov, Iliya K
AU - Aksenov, Nicolai A
AU - Turner, Danielle N
AU - Rogelj, Snezna
AU - Kornienko, Alexander
AU - Rubin, Michael
PY - 2022
DA - 2022/10/19
PB - American Chemical Society (ACS)
SP - 13955-13964
IS - 21
VL - 87
PMID - 36260110
SN - 0022-3263
SN - 1520-6904
ER -
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@article{2022_Aksenov,
author = {Alexander V. Aksenov and Nikita K Kirilov and Nikolai A Arutiunov and Dmitrii A Aksenov and Iliya K Kuzminov and Nicolai A Aksenov and Danielle N Turner and Snezna Rogelj and Alexander Kornienko and Michael Rubin},
title = {Reductive Cleavage of 4′H-Spiro[indole-3,5′-isoxazoles] En Route to 2-(1H-Indol-3-yl)acetamides with Anticancer Activities},
journal = {Journal of Organic Chemistry},
year = {2022},
volume = {87},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/acs.joc.2c01627},
number = {21},
pages = {13955--13964},
doi = {10.1021/acs.joc.2c01627}
}
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MLA
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Aksenov, Alexander V., et al. “Reductive Cleavage of 4′H-Spiro[indole-3,5′-isoxazoles] En Route to 2-(1H-Indol-3-yl)acetamides with Anticancer Activities.” Journal of Organic Chemistry, vol. 87, no. 21, Oct. 2022, pp. 13955-13964. https://doi.org/10.1021/acs.joc.2c01627.
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