LiN(SiMe3)2/KOtBu-Promoted Synthesis of Isoquinolone Derivatives from 2-Methylaryl Aldehydes and Nitriles
Publication type: Journal Article
Publication date: 2023-05-17
scimago Q2
wos Q1
SJR: 0.737
CiteScore: 6.1
Impact factor: 3.6
ISSN: 00223263, 15206904
PubMed ID:
37195013
Organic Chemistry
Abstract
A convenient method is proposed for the synthesis of isoquinolone derivatives from 2-methylaryl aldehydes and nitriles through LiN(SiMe3)2/KOtBu-promoted formal [4 + 2] cycloaddition reaction, featuring high atomic economy, good functional group tolerance, and easy operation. It enables the efficient formation of new C-C and C-N bonds toward isoquinolones without using preactivated amides.
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Metrics
19
Total citations:
19
Citations from 2025:
9
(47.37%)
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MLA
Cite this
GOST
Copy
Ma P. et al. LiN(SiMe3)2/KOtBu-Promoted Synthesis of Isoquinolone Derivatives from 2-Methylaryl Aldehydes and Nitriles // Journal of Organic Chemistry. 2023. Vol. 88. No. 11. pp. 7425-7430.
GOST all authors (up to 50)
Copy
Ma P., Wang Y., Wang J., Ma N. LiN(SiMe3)2/KOtBu-Promoted Synthesis of Isoquinolone Derivatives from 2-Methylaryl Aldehydes and Nitriles // Journal of Organic Chemistry. 2023. Vol. 88. No. 11. pp. 7425-7430.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.joc.3c00698
UR - https://pubs.acs.org/doi/10.1021/acs.joc.3c00698
TI - LiN(SiMe3)2/KOtBu-Promoted Synthesis of Isoquinolone Derivatives from 2-Methylaryl Aldehydes and Nitriles
T2 - Journal of Organic Chemistry
AU - Ma, Peng
AU - Wang, Yuhang
AU - Wang, Jianhui
AU - Ma, Ning
PY - 2023
DA - 2023/05/17
PB - American Chemical Society (ACS)
SP - 7425-7430
IS - 11
VL - 88
PMID - 37195013
SN - 0022-3263
SN - 1520-6904
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2023_Ma,
author = {Peng Ma and Yuhang Wang and Jianhui Wang and Ning Ma},
title = {LiN(SiMe3)2/KOtBu-Promoted Synthesis of Isoquinolone Derivatives from 2-Methylaryl Aldehydes and Nitriles},
journal = {Journal of Organic Chemistry},
year = {2023},
volume = {88},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://pubs.acs.org/doi/10.1021/acs.joc.3c00698},
number = {11},
pages = {7425--7430},
doi = {10.1021/acs.joc.3c00698}
}
Cite this
MLA
Copy
Ma, Peng, et al. “LiN(SiMe3)2/KOtBu-Promoted Synthesis of Isoquinolone Derivatives from 2-Methylaryl Aldehydes and Nitriles.” Journal of Organic Chemistry, vol. 88, no. 11, May. 2023, pp. 7425-7430. https://pubs.acs.org/doi/10.1021/acs.joc.3c00698.