One-Pot Reaction between N-Tosylhydrazones and 2-Nitrobenzyl Bromide: Route to NH-Free C2-Arylindoles
Publication type: Journal Article
Publication date: 2018-12-07
scimago Q2
wos Q1
SJR: 0.737
CiteScore: 6.1
Impact factor: 3.6
ISSN: 00223263, 15206904
PubMed ID:
30523682
Organic Chemistry
Abstract
A one-pot Barluenga coupling between N-tosylhydrazones and nitro-benzyl bromide, followed by deoxygenation of ortho-nitrostyrenes, and subsequent cyclization has been developed, providing a new way to synthesize various C2-arylindoles. This method exhibits a good substrate scope and functional group tolerance, and it allows an access to NH-free indoles, which can present a potential utility in medicinal chemistry applications.
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31
Total citations:
31
Citations from 2024:
11
(35.48%)
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GOST
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Bzeih T. et al. One-Pot Reaction between N-Tosylhydrazones and 2-Nitrobenzyl Bromide: Route to NH-Free C2-Arylindoles // Journal of Organic Chemistry. 2018. Vol. 84. No. 1. pp. 228-238.
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Bzeih T., Zhang K., Khalaf A., Hachem A., Alami M., Hamzé A. One-Pot Reaction between N-Tosylhydrazones and 2-Nitrobenzyl Bromide: Route to NH-Free C2-Arylindoles // Journal of Organic Chemistry. 2018. Vol. 84. No. 1. pp. 228-238.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.joc.8b02623
UR - https://doi.org/10.1021/acs.joc.8b02623
TI - One-Pot Reaction between N-Tosylhydrazones and 2-Nitrobenzyl Bromide: Route to NH-Free C2-Arylindoles
T2 - Journal of Organic Chemistry
AU - Bzeih, Tourin
AU - Zhang, Kena
AU - Khalaf, Ali
AU - Hachem, Ali
AU - Alami, Mouâd
AU - Hamzé, Abdallah
PY - 2018
DA - 2018/12/07
PB - American Chemical Society (ACS)
SP - 228-238
IS - 1
VL - 84
PMID - 30523682
SN - 0022-3263
SN - 1520-6904
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Bzeih,
author = {Tourin Bzeih and Kena Zhang and Ali Khalaf and Ali Hachem and Mouâd Alami and Abdallah Hamzé},
title = {One-Pot Reaction between N-Tosylhydrazones and 2-Nitrobenzyl Bromide: Route to NH-Free C2-Arylindoles},
journal = {Journal of Organic Chemistry},
year = {2018},
volume = {84},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021/acs.joc.8b02623},
number = {1},
pages = {228--238},
doi = {10.1021/acs.joc.8b02623}
}
Cite this
MLA
Copy
Bzeih, Tourin, et al. “One-Pot Reaction between N-Tosylhydrazones and 2-Nitrobenzyl Bromide: Route to NH-Free C2-Arylindoles.” Journal of Organic Chemistry, vol. 84, no. 1, Dec. 2018, pp. 228-238. https://doi.org/10.1021/acs.joc.8b02623.