Preparation of N-Arylquinazolinium Salts via a Cascade Approach
Publication type: Journal Article
Publication date: 2019-05-13
scimago Q2
wos Q1
SJR: 0.737
CiteScore: 6.1
Impact factor: 3.6
ISSN: 00223263, 15206904
PubMed ID:
31082227
Organic Chemistry
Abstract
An easy manipulation method for the preparation of N-arylquinazolinium salts is described from readily available aryldiazonium salts, nitriles, and 2-aminoarylketones in a one-pot operation. This method relies on the in situ generation of the N-arylnitrilium intermediate from the reaction of aryldiazonium salt with nitrile, which undergoes amination/cascade cyclization/aromatization, leading to N-arylquinazolinium salts in excellent yields. Nucleophilic addition of alkoxide to these N-arylquinazolinium salts provides functionalized dihydro- N-arylquinazoline.
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8
Total citations:
8
Citations from 2024:
4
(50%)
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GOST
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Ramanathan M., Wan J., Liu S. Preparation of N-Arylquinazolinium Salts via a Cascade Approach // Journal of Organic Chemistry. 2019. Vol. 84. No. 11. pp. 7459-7467.
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Ramanathan M., Wan J., Liu S. Preparation of N-Arylquinazolinium Salts via a Cascade Approach // Journal of Organic Chemistry. 2019. Vol. 84. No. 11. pp. 7459-7467.
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RIS
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TY - JOUR
DO - 10.1021/acs.joc.9b00601
UR - https://doi.org/10.1021/acs.joc.9b00601
TI - Preparation of N-Arylquinazolinium Salts via a Cascade Approach
T2 - Journal of Organic Chemistry
AU - Ramanathan, Mani
AU - Wan, Jing
AU - Liu, Shiuh-Inn
PY - 2019
DA - 2019/05/13
PB - American Chemical Society (ACS)
SP - 7459-7467
IS - 11
VL - 84
PMID - 31082227
SN - 0022-3263
SN - 1520-6904
ER -
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BibTex (up to 50 authors)
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@article{2019_Ramanathan,
author = {Mani Ramanathan and Jing Wan and Shiuh-Inn Liu},
title = {Preparation of N-Arylquinazolinium Salts via a Cascade Approach},
journal = {Journal of Organic Chemistry},
year = {2019},
volume = {84},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/acs.joc.9b00601},
number = {11},
pages = {7459--7467},
doi = {10.1021/acs.joc.9b00601}
}
Cite this
MLA
Copy
Ramanathan, Mani, et al. “Preparation of N-Arylquinazolinium Salts via a Cascade Approach.” Journal of Organic Chemistry, vol. 84, no. 11, May. 2019, pp. 7459-7467. https://doi.org/10.1021/acs.joc.9b00601.