In Situ Formation and Gelation Mechanism of Thermoresponsive Stereocomplexed Hydrogels upon Mixing Diblock and Triblock Poly(Lactic Acid)/Poly(Ethylene Glycol) Copolymers
Publication type: Journal Article
Publication date: 2015-05-14
scimago Q1
wos Q3
SJR: 0.742
CiteScore: 5.3
Impact factor: 2.9
ISSN: 15206106, 15205207, 10895647
PubMed ID:
25932653
Materials Chemistry
Surfaces, Coatings and Films
Physical and Theoretical Chemistry
Abstract
A novel in situ formed gel system with potential biodegradability and biocompatibility is developed by mixing the diblock and triblock poly(lactic acid)/poly(ethylene glycol) (PLA/PEG) copolymers with opposite configurations of PLA blocks. In situ gelation of such system is extremely fast, which happens within 10 s after mixing. In situ gelation, gel-to-sol transition, crystalline structure, microstructures, and mechanical properties of PLA-PEG/PLA-PEG-PLA enantiomerically mixed gels are significantly influenced by the mixing ratio, degree of polymerization for PEG block in triblock (DPPEG,tri) and diblock copolymers (DPPEG,di). It is found that in situ gelation of PLA-PEG/PLA-PEG-PLA enantiomeric mixture just happen at relatively smaller PLA-PEG/PLA-PEG-PLA mass ratio and larger DPPEG,tri. Hydrodynamic diameters of PLA-PEG and PLA-PEG-PLA copolymers in dilute solution increase remarkably upon mixing, indicating the formation of bridging networks. Stereocomplexed crystallites are formed for the PLA hydrophobic domains in PLA-PEG/PLA-PEG-PLA enantiomeric mixtures. As indicated by synchrotron-radiation SAXS analysis, the enantiomeric mixture changes from a compactly to loosely aggregated structure and the intermicellar distance enhances with increasing DPPEG,tri, DPPEG,di, or PLA-PEG-PLA fraction. Gelation mechanism of PLA-PEG/PLA-PEG-PLA enantiomeric mixture is proposed, in which part of PLA-PEG-PLA chains act as the connecting bridges between star and flower-like micelles and the stereocomplexed crystallites in micelle cores act as physically cross-linked points.
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Total citations:
65
Citations from 2025:
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(9.23%)
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Mao H. et al. In Situ Formation and Gelation Mechanism of Thermoresponsive Stereocomplexed Hydrogels upon Mixing Diblock and Triblock Poly(Lactic Acid)/Poly(Ethylene Glycol) Copolymers // Journal of Physical Chemistry B. 2015. Vol. 119. No. 21. pp. 6471-6480.
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Mao H., Pan P., Shan G., Bao Y. In Situ Formation and Gelation Mechanism of Thermoresponsive Stereocomplexed Hydrogels upon Mixing Diblock and Triblock Poly(Lactic Acid)/Poly(Ethylene Glycol) Copolymers // Journal of Physical Chemistry B. 2015. Vol. 119. No. 21. pp. 6471-6480.
Cite this
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TY - JOUR
DO - 10.1021/acs.jpcb.5b03610
UR - https://doi.org/10.1021/acs.jpcb.5b03610
TI - In Situ Formation and Gelation Mechanism of Thermoresponsive Stereocomplexed Hydrogels upon Mixing Diblock and Triblock Poly(Lactic Acid)/Poly(Ethylene Glycol) Copolymers
T2 - Journal of Physical Chemistry B
AU - Mao, Hailiang
AU - Pan, Pengju
AU - Shan, Guorong
AU - Bao, Yong-Zhong
PY - 2015
DA - 2015/05/14
PB - American Chemical Society (ACS)
SP - 6471-6480
IS - 21
VL - 119
PMID - 25932653
SN - 1520-6106
SN - 1520-5207
SN - 1089-5647
ER -
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@article{2015_Mao,
author = {Hailiang Mao and Pengju Pan and Guorong Shan and Yong-Zhong Bao},
title = {In Situ Formation and Gelation Mechanism of Thermoresponsive Stereocomplexed Hydrogels upon Mixing Diblock and Triblock Poly(Lactic Acid)/Poly(Ethylene Glycol) Copolymers},
journal = {Journal of Physical Chemistry B},
year = {2015},
volume = {119},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/acs.jpcb.5b03610},
number = {21},
pages = {6471--6480},
doi = {10.1021/acs.jpcb.5b03610}
}
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MLA
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Mao, Hailiang, et al. “In Situ Formation and Gelation Mechanism of Thermoresponsive Stereocomplexed Hydrogels upon Mixing Diblock and Triblock Poly(Lactic Acid)/Poly(Ethylene Glycol) Copolymers.” Journal of Physical Chemistry B, vol. 119, no. 21, May. 2015, pp. 6471-6480. https://doi.org/10.1021/acs.jpcb.5b03610.