Open Access

Journal of Physical Chemistry C, volume 121, issue 50, pages 28096-28105

Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery

Permyakova Elizaveta S ¹

Sukhorukova I V ¹

Antipina Liubov Yu ^{1, 2}

Konopatsky Anton ¹

Kovalskii A. M. ¹

Matveev A.T. ¹

Lebedev Oleg ³

Golberg Dmitri ^{4, 5}

Manakhov Anton ¹

Shtansky Dmitry V. ¹

Hide authors affiliations Show authors affiliations: 5 affiliations

National University of Science and Technology “MISIS”, Leninsky Prospect 4, Moscow 119049, Russia |

Institute of Biochemical Physics RAS, 4 Kosygina str., Moscow 119334, Russia |

Laboratoire CRISMAT, UMR 6508, CNRS-ENSICAEN, 6Bd Marechal Juin, 14050 Caen, France |

⁴

National Institute for Materials Science (NIMS), Namiki 1-1, Tsukuba, Ibaraki 3050044, Japan |

⁵

Queensland University of Technology (QUT), Second George St., Brisbane, QLD 4000, Australia |

Publication type: Journal Article

Publication date: 2017-12-08

American Chemical Society (ACS)

Journal: Journal of Physical Chemistry C

Quartile SCImago

Quartile WOS

Impact factor: 3.7

ISSN: 19327447, 19327455

DOI: 10.1021/acs.jpcc.7b10841

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Surfaces, Coatings and Films

Electronic, Optical and Magnetic Materials

Physical and Theoretical Chemistry

General Energy

Abstract

We have developed advanced folate bonded to boron nitride (BN) nanocarriers with a high potential for targeted drug delivery. The folic acid (FA) molecules were successfully conjugated to BN nanoparticles (BNNPs) in three consecutive stages: (i) FA preactivation by N,N′-dicyclohexylcarbodiimide (DCC), (ii) BNNP modification by AgNPs and their further NH2-functionalization with l-cysteine, and (iii) final conjugation of activated FA to modified BNNPs. To shed light on the FA-BNNPs binding mechanism, detailed energetic analysis of the atomic structure and stability of the FA-BNNPs system using density functional theory (DFT) calculations was carried out. The results indicated that the FA was successfully bonded with the BNNPs by a condensation reaction between amino groups of Cyst-Ag/BNNPs and carboxyl groups of FA using DCC. Theoretical analysis also demonstrated that the grafting of FA to the surface of BNNP does not affect FA targeting properties.

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Citations by journals

	1 2 3
Journal of Molecular Liquids	Journal of Molecular Liquids, 3, 10.71% Journal of Molecular Liquids 3 publications, 10.71%
Journal of Molecular Graphics and Modelling	Journal of Molecular Graphics and Modelling, 2, 7.14% Journal of Molecular Graphics and Modelling 2 publications, 7.14%
Journal of Biomolecular Structure and Dynamics	Journal of Biomolecular Structure and Dynamics, 2, 7.14% Journal of Biomolecular Structure and Dynamics 2 publications, 7.14%
Journal of Physical Chemistry C	Journal of Physical Chemistry C, 1, 3.57% Journal of Physical Chemistry C 1 publication, 3.57%
Nanomaterials	Nanomaterials, 1, 3.57% Nanomaterials 1 publication, 3.57%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 3.57% International Journal of Molecular Sciences 1 publication, 3.57%
Applied Physics Reviews	Applied Physics Reviews, 1, 3.57% Applied Physics Reviews 1 publication, 3.57%
Polymers	Polymers, 1, 3.57% Polymers 1 publication, 3.57%
Frontiers in Bioengineering and Biotechnology	Frontiers in Bioengineering and Biotechnology, 1, 3.57% Frontiers in Bioengineering and Biotechnology 1 publication, 3.57%
Scientific Reports	Scientific Reports, 1, 3.57% Scientific Reports 1 publication, 3.57%
Arabian Journal of Chemistry	Arabian Journal of Chemistry, 1, 3.57% Arabian Journal of Chemistry 1 publication, 3.57%
Biomaterials	Biomaterials, 1, 3.57% Biomaterials 1 publication, 3.57%
Microchemical Journal	Microchemical Journal, 1, 3.57% Microchemical Journal 1 publication, 3.57%
Applied Surface Science	Applied Surface Science, 1, 3.57% Applied Surface Science 1 publication, 3.57%
Ceramics International	Ceramics International, 1, 3.57% Ceramics International 1 publication, 3.57%
Journal of Controlled Release	Journal of Controlled Release, 1, 3.57% Journal of Controlled Release 1 publication, 3.57%
Computational and Theoretical Chemistry	Computational and Theoretical Chemistry, 1, 3.57% Computational and Theoretical Chemistry 1 publication, 3.57%
Langmuir	Langmuir, 1, 3.57% Langmuir 1 publication, 3.57%
Nanoscale	Nanoscale, 1, 3.57% Nanoscale 1 publication, 3.57%
RSC Advances	RSC Advances, 1, 3.57% RSC Advances 1 publication, 3.57%
ACS Applied Bio Materials	ACS Applied Bio Materials, 1, 3.57% ACS Applied Bio Materials 1 publication, 3.57%
Advanced Materials	Advanced Materials, 1, 3.57% Advanced Materials 1 publication, 3.57%
Small	Small, 1, 3.57% Small 1 publication, 3.57%
Structural Composite Materials	Structural Composite Materials, 1, 3.57% Structural Composite Materials 1 publication, 3.57%
	1 2 3

Citations by publishers

	2 4 6 8 10 12
Elsevier	Elsevier, 11, 39.29% Elsevier 11 publications, 39.29%
American Chemical Society (ACS)	American Chemical Society (ACS), 3, 10.71% American Chemical Society (ACS) 3 publications, 10.71%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 3, 10.71% Multidisciplinary Digital Publishing Institute (MDPI) 3 publications, 10.71%
Springer Nature	Springer Nature, 2, 7.14% Springer Nature 2 publications, 7.14%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 2, 7.14% Royal Society of Chemistry (RSC) 2 publications, 7.14%
Taylor & Francis	Taylor & Francis, 2, 7.14% Taylor & Francis 2 publications, 7.14%
Wiley	Wiley, 2, 7.14% Wiley 2 publications, 7.14%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 1, 3.57% American Institute of Physics (AIP) 1 publication, 3.57%
Frontiers Media S.A.	Frontiers Media S.A., 1, 3.57% Frontiers Media S.A. 1 publication, 3.57%
King Saud University	King Saud University, 1, 3.57% King Saud University 1 publication, 3.57%
	2 4 6 8 10 12

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Permyakova E. S. et al. Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery // Journal of Physical Chemistry C. 2017. Vol. 121. No. 50. pp. 28096-28105.

GOST all authors (up to 50) Copy

Permyakova E. S., Sukhorukova I. V., Antipina L. Yu., Konopatsky A., Kovalskii A. M., Matveev A., Lebedev O., Golberg D., Manakhov A., Shtansky D. V. Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery // Journal of Physical Chemistry C. 2017. Vol. 121. No. 50. pp. 28096-28105.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/acs.jpcc.7b10841

UR - https://doi.org/10.1021%2Facs.jpcc.7b10841

TI - Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery

T2 - Journal of Physical Chemistry C

AU - Permyakova, Elizaveta S

AU - Sukhorukova, I V

AU - Shtansky, Dmitry V.

AU - Antipina, Liubov Yu

AU - Konopatsky, Anton

AU - Kovalskii, A. M.

AU - Matveev, A.T.

AU - Lebedev, Oleg

AU - Golberg, Dmitri

AU - Manakhov, Anton

PY - 2017

DA - 2017/12/08 00:00:00

PB - American Chemical Society (ACS)

SP - 28096-28105

IS - 50

VL - 121

SN - 1932-7447

SN - 1932-7455

ER -

BibTex |

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BibTex Copy

@article{2017_Permyakova,

author = {Elizaveta S Permyakova and I V Sukhorukova and Dmitry V. Shtansky and Liubov Yu Antipina and Anton Konopatsky and A. M. Kovalskii and A.T. Matveev and Oleg Lebedev and Dmitri Golberg and Anton Manakhov},

title = {Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery},

journal = {Journal of Physical Chemistry C},

year = {2017},

volume = {121},

publisher = {American Chemical Society (ACS)},

month = {dec},

url = {https://doi.org/10.1021%2Facs.jpcc.7b10841},

number = {50},

pages = {28096--28105},

doi = {10.1021/acs.jpcc.7b10841}

}

MLA

Cite this

MLA Copy

Permyakova, Elizaveta S., et al. “Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery.” Journal of Physical Chemistry C, vol. 121, no. 50, Dec. 2017, pp. 28096-28105. https://doi.org/10.1021%2Facs.jpcc.7b10841.

Found error?

Publisher

American Chemical Society (ACS)

Journal

Journal of Physical Chemistry C

Quartile SCImago

Quartile WOS

Impact factor

3.7

ISSN

19327447 (Print)
19327455 (Electronic)

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