Open Access

Journal of Physical Chemistry C

, volume 121 , issue 50 , pages 28096-28105

Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery

Elizaveta S Permyakova ¹

I V Sukhorukova ¹

Liubov Yu Antipina ^{1, 2}

Anton Konopatsky ¹

A. M. Kovalskii ¹

A.T. Matveev ¹

Oleg Lebedev ³

Dmitri Golberg ^{4, 5}

Anton Manakhov ¹

Dmitry V. Shtansky ¹

Hide authors affiliations Show authors affiliations: 5 affiliations

National University of Science and Technology “MISIS”, Leninsky Prospect 4, Moscow 119049, Russia |

Institute of Biochemical Physics RAS, 4 Kosygina str., Moscow 119334, Russia |

Laboratoire CRISMAT, UMR 6508, CNRS-ENSICAEN, 6Bd Marechal Juin, 14050 Caen, France |

⁴

National Institute for Materials Science (NIMS), Namiki 1-1, Tsukuba, Ibaraki 3050044, Japan |

⁵

Queensland University of Technology (QUT), Second George St., Brisbane, QLD 4000, Australia |

Publication type: Journal Article

Publication date: 2017-12-08

American Chemical Society (ACS)

Journal of Physical Chemistry C

scimago Q1

wos Q3

SJR: 0.914

CiteScore: 6.2

Impact factor: 3.2

ISSN: 19327447, 19327455

DOI: 10.1021/acs.jpcc.7b10841

Copy DOI

Surfaces, Coatings and Films

Electronic, Optical and Magnetic Materials

Physical and Theoretical Chemistry

General Energy

Abstract

We have developed advanced folate bonded to boron nitride (BN) nanocarriers with a high potential for targeted drug delivery. The folic acid (FA) molecules were successfully conjugated to BN nanoparticles (BNNPs) in three consecutive stages: (i) FA preactivation by N,N′-dicyclohexylcarbodiimide (DCC), (ii) BNNP modification by AgNPs and their further NH2-functionalization with l-cysteine, and (iii) final conjugation of activated FA to modified BNNPs. To shed light on the FA-BNNPs binding mechanism, detailed energetic analysis of the atomic structure and stability of the FA-BNNPs system using density functional theory (DFT) calculations was carried out. The results indicated that the FA was successfully bonded with the BNNPs by a condensation reaction between amino groups of Cyst-Ag/BNNPs and carboxyl groups of FA using DCC. Theoretical analysis also demonstrated that the grafting of FA to the surface of BNNP does not affect FA targeting properties.

Found

4 citations

Kotyakova Kristina

PhD in Engineering

18 publications, 217 citations

h-index: 7

National University of Science & Technology (MISiS)

3 citations

Antipina Liubov

🥼 🤝

PhD in Physics and Mathematics

38 publications, 738 citations, 5 reviews

h-index: 14

National University of Science & Technology (MISiS)

Theoretical Chemistry

Water treatment

3 citations

Sorokin Pavel

🥼 🤝

DSc in Physics and Mathematics, associate professor

200 publications, 8 152 citations, 21 reviews

h-index: 40

National University of Science & Technology (MISiS)

Institute of Microelectronics Technology and High Purity Materials of the Russian Academy of Sciences

Research interests

2D Materials

Ab initio

Computational chemistry

Condensed matter physics

Density functional theory (DFT)

Nanomaterials for biomedicine

Non-covalent Interactions

3 citations

Permyakova Elizaveta

55 publications, 959 citations, 5 reviews

h-index: 19

National University of Science & Technology (MISiS)

1 citation

Maslakov Konstantin

PhD in Physics and Mathematics

347 publications, 5 613 citations, 35 reviews

h-index: 35

Lomonosov Moscow State University

National Research Centre "Kurchatov Institute"

1 citation

Varlamova Lyubov

14 publications, 69 citations, 1 review

h-index: 7

National University of Science & Technology (MISiS)

Research interests

2D Materials

Density functional theory (DFT)

Graphene

Quantum Chemistry

1 citation

Shchetinin Igor

PhD in Engineering, associate professor

187 publications, 2 137 citations, 4 reviews

h-index: 26

National University of Science & Technology (MISiS)

1 citation

Timoshenko Roman

28 publications, 241 citations

h-index: 10

Top-30

Journals

	1 2 3 4
Journal of Molecular Liquids	Journal of Molecular Liquids, 4, 10.26% Journal of Molecular Liquids 4 publications, 10.26%
Journal of Molecular Graphics and Modelling	Journal of Molecular Graphics and Modelling, 3, 7.69% Journal of Molecular Graphics and Modelling 3 publications, 7.69%
Ceramics International	Ceramics International, 3, 7.69% Ceramics International 3 publications, 7.69%
Computational and Theoretical Chemistry	Computational and Theoretical Chemistry, 2, 5.13% Computational and Theoretical Chemistry 2 publications, 5.13%
Journal of Biomolecular Structure and Dynamics	Journal of Biomolecular Structure and Dynamics, 2, 5.13% Journal of Biomolecular Structure and Dynamics 2 publications, 5.13%
ACS Applied Bio Materials	ACS Applied Bio Materials, 2, 5.13% ACS Applied Bio Materials 2 publications, 5.13%
Journal of Physical Chemistry C	Journal of Physical Chemistry C, 1, 2.56% Journal of Physical Chemistry C 1 publication, 2.56%
Nanomaterials	Nanomaterials, 1, 2.56% Nanomaterials 1 publication, 2.56%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 2.56% International Journal of Molecular Sciences 1 publication, 2.56%
Applied Physics Reviews	Applied Physics Reviews, 1, 2.56% Applied Physics Reviews 1 publication, 2.56%
Polymers	Polymers, 1, 2.56% Polymers 1 publication, 2.56%
Frontiers in Bioengineering and Biotechnology	Frontiers in Bioengineering and Biotechnology, 1, 2.56% Frontiers in Bioengineering and Biotechnology 1 publication, 2.56%
Scientific Reports	Scientific Reports, 1, 2.56% Scientific Reports 1 publication, 2.56%
Arabian Journal of Chemistry	Arabian Journal of Chemistry, 1, 2.56% Arabian Journal of Chemistry 1 publication, 2.56%
Biomaterials	Biomaterials, 1, 2.56% Biomaterials 1 publication, 2.56%
Microchemical Journal	Microchemical Journal, 1, 2.56% Microchemical Journal 1 publication, 2.56%
Applied Surface Science	Applied Surface Science, 1, 2.56% Applied Surface Science 1 publication, 2.56%
Journal of Controlled Release	Journal of Controlled Release, 1, 2.56% Journal of Controlled Release 1 publication, 2.56%
Langmuir	Langmuir, 1, 2.56% Langmuir 1 publication, 2.56%
Nanoscale	Nanoscale, 1, 2.56% Nanoscale 1 publication, 2.56%
RSC Advances	RSC Advances, 1, 2.56% RSC Advances 1 publication, 2.56%
Advanced Materials	Advanced Materials, 1, 2.56% Advanced Materials 1 publication, 2.56%
Small	Small, 1, 2.56% Small 1 publication, 2.56%
Structural Composite Materials	Structural Composite Materials, 1, 2.56% Structural Composite Materials 1 publication, 2.56%
Chemical Physics Letters	Chemical Physics Letters, 1, 2.56% Chemical Physics Letters 1 publication, 2.56%
Nanoscale Advances	Nanoscale Advances, 1, 2.56% Nanoscale Advances 1 publication, 2.56%
Key Engineering Materials	Key Engineering Materials, 1, 2.56% Key Engineering Materials 1 publication, 2.56%
ChemistrySelect	ChemistrySelect, 1, 2.56% ChemistrySelect 1 publication, 2.56%
	1 2 3 4

Publishers

	2 4 6 8 10 12 14 16 18
Elsevier	Elsevier, 17, 43.59% Elsevier 17 publications, 43.59%
American Chemical Society (ACS)	American Chemical Society (ACS), 4, 10.26% American Chemical Society (ACS) 4 publications, 10.26%
MDPI	MDPI, 3, 7.69% MDPI 3 publications, 7.69%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 3, 7.69% Royal Society of Chemistry (RSC) 3 publications, 7.69%
Wiley	Wiley, 3, 7.69% Wiley 3 publications, 7.69%
Springer Nature	Springer Nature, 2, 5.13% Springer Nature 2 publications, 5.13%
Taylor & Francis	Taylor & Francis, 2, 5.13% Taylor & Francis 2 publications, 5.13%
AIP Publishing	AIP Publishing, 1, 2.56% AIP Publishing 1 publication, 2.56%
Frontiers Media S.A.	Frontiers Media S.A., 1, 2.56% Frontiers Media S.A. 1 publication, 2.56%
King Saud University	King Saud University, 1, 2.56% King Saud University 1 publication, 2.56%
Trans Tech Publications	Trans Tech Publications, 1, 2.56% Trans Tech Publications 1 publication, 2.56%
Bentham Science Publishers Ltd.	Bentham Science Publishers Ltd., 1, 2.56% Bentham Science Publishers Ltd. 1 publication, 2.56%
	2 4 6 8 10 12 14 16 18

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST |

Cite this

GOST Copy

Permyakova E. S. et al. Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery // Journal of Physical Chemistry C. 2017. Vol. 121. No. 50. pp. 28096-28105.

GOST all authors (up to 50) Copy

Permyakova E. S., Sukhorukova I. V., Antipina L. Yu., Konopatsky A., Kovalskii A. M., Matveev A., Lebedev O., Golberg D., Manakhov A., Shtansky D. V. Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery // Journal of Physical Chemistry C. 2017. Vol. 121. No. 50. pp. 28096-28105.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1021/acs.jpcc.7b10841

UR - https://doi.org/10.1021/acs.jpcc.7b10841

TI - Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery

T2 - Journal of Physical Chemistry C

AU - Permyakova, Elizaveta S

AU - Sukhorukova, I V

AU - Antipina, Liubov Yu

AU - Konopatsky, Anton

AU - Kovalskii, A. M.

AU - Matveev, A.T.

AU - Lebedev, Oleg

AU - Golberg, Dmitri

AU - Manakhov, Anton

AU - Shtansky, Dmitry V.

PY - 2017

DA - 2017/12/08

PB - American Chemical Society (ACS)

SP - 28096-28105

IS - 50

VL - 121

SN - 1932-7447

SN - 1932-7455

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2017_Permyakova,

author = {Elizaveta S Permyakova and I V Sukhorukova and Liubov Yu Antipina and Anton Konopatsky and A. M. Kovalskii and A.T. Matveev and Oleg Lebedev and Dmitri Golberg and Anton Manakhov and Dmitry V. Shtansky},

title = {Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery},

journal = {Journal of Physical Chemistry C},

year = {2017},

volume = {121},

publisher = {American Chemical Society (ACS)},

month = {dec},

url = {https://doi.org/10.1021/acs.jpcc.7b10841},

number = {50},

pages = {28096--28105},

doi = {10.1021/acs.jpcc.7b10841}

}

MLA

Cite this

MLA Copy

Permyakova, Elizaveta S., et al. “Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery.” Journal of Physical Chemistry C, vol. 121, no. 50, Dec. 2017, pp. 28096-28105. https://doi.org/10.1021/acs.jpcc.7b10841.

Publisher

American Chemical Society (ACS)

Journal

Journal of Physical Chemistry C

scimago Q1

wos Q3

SJR

0.914

CiteScore

6.2

Impact factor

3.2

ISSN

19327447 (Print)

19327455 (Electronic)

Profiles