Open Access
Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery
Тип публикации: Journal Article
Дата публикации: 2017-12-08
scimago Q1
wos Q3
БС1
SJR: 0.914
CiteScore: 6.2
Impact factor: 3.2
ISSN: 19327447, 19327455
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Physical and Theoretical Chemistry
General Energy
Краткое описание
We have developed advanced folate bonded to boron nitride (BN) nanocarriers with a high potential for targeted drug delivery. The folic acid (FA) molecules were successfully conjugated to BN nanoparticles (BNNPs) in three consecutive stages: (i) FA preactivation by N,N′-dicyclohexylcarbodiimide (DCC), (ii) BNNP modification by AgNPs and their further NH2-functionalization with l-cysteine, and (iii) final conjugation of activated FA to modified BNNPs. To shed light on the FA-BNNPs binding mechanism, detailed energetic analysis of the atomic structure and stability of the FA-BNNPs system using density functional theory (DFT) calculations was carried out. The results indicated that the FA was successfully bonded with the BNNPs by a condensation reaction between amino groups of Cyst-Ag/BNNPs and carboxyl groups of FA using DCC. Theoretical analysis also demonstrated that the grafting of FA to the surface of BNNP does not affect FA targeting properties.
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ГОСТ
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Permyakova E. S. et al. Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery // Journal of Physical Chemistry C. 2017. Vol. 121. No. 50. pp. 28096-28105.
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Permyakova E. S., Sukhorukova I. V., Antipina L. Yu., Konopatsky A., Kovalskii A. M., Matveev A., Lebedev O., Golberg D., Manakhov A., Shtansky D. V. Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery // Journal of Physical Chemistry C. 2017. Vol. 121. No. 50. pp. 28096-28105.
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TY - JOUR
DO - 10.1021/acs.jpcc.7b10841
UR - https://doi.org/10.1021/acs.jpcc.7b10841
TI - Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery
T2 - Journal of Physical Chemistry C
AU - Permyakova, Elizaveta S
AU - Sukhorukova, I V
AU - Antipina, Liubov Yu
AU - Konopatsky, Anton
AU - Kovalskii, A. M.
AU - Matveev, A.T.
AU - Lebedev, Oleg
AU - Golberg, Dmitri
AU - Manakhov, Anton
AU - Shtansky, Dmitry V.
PY - 2017
DA - 2017/12/08
PB - American Chemical Society (ACS)
SP - 28096-28105
IS - 50
VL - 121
SN - 1932-7447
SN - 1932-7455
ER -
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BibTex (до 50 авторов)
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@article{2017_Permyakova,
author = {Elizaveta S Permyakova and I V Sukhorukova and Liubov Yu Antipina and Anton Konopatsky and A. M. Kovalskii and A.T. Matveev and Oleg Lebedev and Dmitri Golberg and Anton Manakhov and Dmitry V. Shtansky},
title = {Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery},
journal = {Journal of Physical Chemistry C},
year = {2017},
volume = {121},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021/acs.jpcc.7b10841},
number = {50},
pages = {28096--28105},
doi = {10.1021/acs.jpcc.7b10841}
}
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MLA
Скопировать
Permyakova, Elizaveta S., et al. “Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery.” Journal of Physical Chemistry C, vol. 121, no. 50, Dec. 2017, pp. 28096-28105. https://doi.org/10.1021/acs.jpcc.7b10841.