Langmuir, volume 34, issue 46, pages 13935-13945
Bare and Sterically Stabilized PLGA Nanoparticles for the Stabilization of Pickering Emulsions
Albert Claire
1
,
Huang Nicolas
1
,
Tsapis Nicolas
1
,
Geiger Sandrine
1, 2
,
Rosilio Véronique
1
,
Mekhloufi Ghozlene
1
,
Chapron David
1
,
Robin Baptiste
1
,
Beladjine Mohamed
1
,
Nicolas Valérie
3
,
Fattal Elias
1
,
Agnely Florence
1
1
Institut Galien Paris-Sud, CNRS UMR 8612, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie, 5 rue J.B. Clément, F-92296 Châtenay-Malabry, France
|
2
Laboratoire Structures, Propriétés et Modélisation des Solides (SPMS) UMR CNRS 8580, CentraleSupélec, Université Paris-Saclay, 3 Rue Joliot Curie, 91190 Gif-sur-Yvette, France
|
3
Plateforme d’imagerie cellulaire MIPSIT, SFR-UMS-IPSIT, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie, 5 rue J.B. Clément, F-92296 Châtenay-Malabry, France
|
Publication type: Journal Article
Publication date: 2018-10-23
Spectroscopy
Electrochemistry
Condensed Matter Physics
General Materials Science
Surfaces and Interfaces
Abstract
Pickering emulsions were formulated using biodegradable and biocompatible poly(lactic- co-glycolic acid) (PLGA) nanoparticles (NPs) prepared without surfactants or any other polymer than PLGA. A pharmaceutical and cosmetic oil (Miglyol) was chosen as the oil phase at a ratio of 10% w/w. These emulsions were then compared with emulsions using the same oil but formulated with well-described PLGA-poly(vinyl alcohol) (PVA) NPs, i.e., with PVA as NP stabilizers. Strikingly, the emulsions demonstrated very different structures at macroscopic, microscopic, and interfacial scales, depending on the type of NPs used. Indeed, the emulsion layer was significantly thicker when using PLGA NPs rather than PLGA-PVA NPs. This was attributed to the formation and coexistence of multiple water-in-oil-in-water (W/O/W) and simple oil-in-water (O/W) droplets, using a single step of emulsification, whereas simple O/W emulsions were obtained with PLGA-PVA NPs. The latter NPs were more hydrophilic than bare PLGA NPs because of the presence of PVA at their surface. Moreover, PLGA NPs only slightly lowered the oil/water interfacial tension whereas the decrease was more pronounced with PLGA-PVA NPs. The PVA chains at the PLGA-PVA NP surface could probably partially desorb from the NPs and adsorb at the interface, inducing the interfacial tension decrease. Finally, independent of their composition, NPs were adsorbed at the oil/water interface without influencing its rheological behavior, possibly due to their mobility at their interface. This work has direct implications in the formulation of Pickering emulsions and stresses the paramount influence of the physicochemical nature of the NP surface into the stabilization of these systems.
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5
10
15
20
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Albert C. et al. Bare and Sterically Stabilized PLGA Nanoparticles for the Stabilization of Pickering Emulsions // Langmuir. 2018. Vol. 34. No. 46. pp. 13935-13945.
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Albert C., Huang N., Tsapis N., Geiger S., Rosilio V., Mekhloufi G., Chapron D., Robin B., Beladjine M., Nicolas V., Fattal E., Agnely F. Bare and Sterically Stabilized PLGA Nanoparticles for the Stabilization of Pickering Emulsions // Langmuir. 2018. Vol. 34. No. 46. pp. 13935-13945.
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TY - JOUR
DO - 10.1021/acs.langmuir.8b02558
UR - https://doi.org/10.1021%2Facs.langmuir.8b02558
TI - Bare and Sterically Stabilized PLGA Nanoparticles for the Stabilization of Pickering Emulsions
T2 - Langmuir
AU - Albert, Claire
AU - Geiger, Sandrine
AU - Rosilio, Véronique
AU - Mekhloufi, Ghozlene
AU - Chapron, David
AU - Robin, Baptiste
AU - Beladjine, Mohamed
AU - Agnely, Florence
AU - Huang, Nicolas
AU - Tsapis, Nicolas
AU - Fattal, Elias
AU - Nicolas, Valérie
PY - 2018
DA - 2018/10/23 00:00:00
PB - American Chemical Society (ACS)
SP - 13935-13945
IS - 46
VL - 34
SN - 0743-7463
SN - 1520-5827
ER -
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@article{2018_Albert,
author = {Claire Albert and Sandrine Geiger and Véronique Rosilio and Ghozlene Mekhloufi and David Chapron and Baptiste Robin and Mohamed Beladjine and Florence Agnely and Nicolas Huang and Nicolas Tsapis and Elias Fattal and Valérie Nicolas},
title = {Bare and Sterically Stabilized PLGA Nanoparticles for the Stabilization of Pickering Emulsions},
journal = {Langmuir},
year = {2018},
volume = {34},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021%2Facs.langmuir.8b02558},
number = {46},
pages = {13935--13945},
doi = {10.1021/acs.langmuir.8b02558}
}
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MLA
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Albert, Claire, et al. “Bare and Sterically Stabilized PLGA Nanoparticles for the Stabilization of Pickering Emulsions.” Langmuir, vol. 34, no. 46, Oct. 2018, pp. 13935-13945. https://doi.org/10.1021%2Facs.langmuir.8b02558.