Alkylverdazyls as a Source of Alkyl Radicals for Light-Triggered Cancer Cell Death
Darya E Votkina
1
,
Evgenii V Plotnikov
1
,
Pavel Petunin
1
,
Elizaveta S Berdinskaya
1
,
Maria S Tretyakova
1
,
Gérard Audran
2
,
Pavel S. Postnikov
1, 3
Publication type: Journal Article
Publication date: 2021-12-10
scimago Q1
wos Q1
SJR: 0.968
CiteScore: 7.8
Impact factor: 4.5
ISSN: 15438384, 15438392
PubMed ID:
34889598
Drug Discovery
Pharmaceutical Science
Molecular Medicine
Abstract
Two alkylated verdazyl radicals (AlkVZs) were investigated as active compounds for photoinitiated controlled MCF-7 cell death. Observed results unambiguously showed that AlkVZ could be a potential structural moiety for the design of a novel family of photodynamic therapy agents. The main advantage of the proposed substances is an oxygen-independent generation of active radicals, which play a pivotal role in the treatment of oxygen-deficient tumors.
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Votkina D. E. et al. Alkylverdazyls as a Source of Alkyl Radicals for Light-Triggered Cancer Cell Death // Molecular Pharmaceutics. 2021. Vol. 19. No. 1. pp. 354-357.
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Votkina D. E., Plotnikov E. V., Petunin P., Berdinskaya E. S., Tretyakova M. S., Audran G., Marque S. R. A., Postnikov P. S. Alkylverdazyls as a Source of Alkyl Radicals for Light-Triggered Cancer Cell Death // Molecular Pharmaceutics. 2021. Vol. 19. No. 1. pp. 354-357.
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RIS
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TY - JOUR
DO - 10.1021/acs.molpharmaceut.1c00780
UR - https://doi.org/10.1021/acs.molpharmaceut.1c00780
TI - Alkylverdazyls as a Source of Alkyl Radicals for Light-Triggered Cancer Cell Death
T2 - Molecular Pharmaceutics
AU - Votkina, Darya E
AU - Plotnikov, Evgenii V
AU - Petunin, Pavel
AU - Berdinskaya, Elizaveta S
AU - Tretyakova, Maria S
AU - Audran, Gérard
AU - Marque, Sylvain R. A.
AU - Postnikov, Pavel S.
PY - 2021
DA - 2021/12/10
PB - American Chemical Society (ACS)
SP - 354-357
IS - 1
VL - 19
PMID - 34889598
SN - 1543-8384
SN - 1543-8392
ER -
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BibTex (up to 50 authors)
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@article{2021_Votkina,
author = {Darya E Votkina and Evgenii V Plotnikov and Pavel Petunin and Elizaveta S Berdinskaya and Maria S Tretyakova and Gérard Audran and Sylvain R. A. Marque and Pavel S. Postnikov},
title = {Alkylverdazyls as a Source of Alkyl Radicals for Light-Triggered Cancer Cell Death},
journal = {Molecular Pharmaceutics},
year = {2021},
volume = {19},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021/acs.molpharmaceut.1c00780},
number = {1},
pages = {354--357},
doi = {10.1021/acs.molpharmaceut.1c00780}
}
Cite this
MLA
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Votkina, Darya E., et al. “Alkylverdazyls as a Source of Alkyl Radicals for Light-Triggered Cancer Cell Death.” Molecular Pharmaceutics, vol. 19, no. 1, Dec. 2021, pp. 354-357. https://doi.org/10.1021/acs.molpharmaceut.1c00780.