A Review of Tangential Flow Filtration: Process Development and Applications in the Pharmaceutical Industry
Paridhi Agrawal
1
,
Katerina Wilkstein
1
,
Emily Guinn
1
,
Mckensie L Mason
1
,
Carolina I. Serrano Martinez
1
,
Jeremiah Saylae
2
1
Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana 46225, United States
|
2
Manchester University, North Manchester, Indiana 46962, United States
|
Publication type: Journal Article
Publication date: 2023-03-31
scimago Q1
wos Q1
SJR: 0.865
CiteScore: 5.4
Impact factor: 3.5
ISSN: 10836160, 1520586X
Organic Chemistry
Physical and Theoretical Chemistry
Abstract
Tangential flow filtration is an efficient membrane separation technology utilized across a wide range of industries for separation and purification applications. The requirement of telescoped manufacturing to produce high-volume drugs in the pharmaceutical industry has led to increased adoption of membrane separation for drug substance synthesis. Particularly, for noncrystalline molecules with limited product stability and significant thermal liabilities, TFF is a powerful alternative to traditional isolation techniques. This Review discusses the various considerations during the development of a TFF process and highlights applications of TFF to produce pharmaceutically relevant molecules such as proteins, peptides, monoclonal antibodies, and so on. Finally, a future perspective on the technology is shared for improved performance.
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Metrics
42
Total citations:
42
Citations from 2024:
35
(83.33%)
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MLA
Cite this
GOST
Copy
Agrawal P. et al. A Review of Tangential Flow Filtration: Process Development and Applications in the Pharmaceutical Industry // Organic Process Research and Development. 2023. Vol. 27. No. 4. pp. 571-591.
GOST all authors (up to 50)
Copy
Agrawal P., Wilkstein K., Guinn E., Mason M. L., Serrano Martinez C. I., Saylae J. A Review of Tangential Flow Filtration: Process Development and Applications in the Pharmaceutical Industry // Organic Process Research and Development. 2023. Vol. 27. No. 4. pp. 571-591.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.oprd.2c00291
UR - https://pubs.acs.org/doi/10.1021/acs.oprd.2c00291
TI - A Review of Tangential Flow Filtration: Process Development and Applications in the Pharmaceutical Industry
T2 - Organic Process Research and Development
AU - Agrawal, Paridhi
AU - Wilkstein, Katerina
AU - Guinn, Emily
AU - Mason, Mckensie L
AU - Serrano Martinez, Carolina I.
AU - Saylae, Jeremiah
PY - 2023
DA - 2023/03/31
PB - American Chemical Society (ACS)
SP - 571-591
IS - 4
VL - 27
SN - 1083-6160
SN - 1520-586X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2023_Agrawal,
author = {Paridhi Agrawal and Katerina Wilkstein and Emily Guinn and Mckensie L Mason and Carolina I. Serrano Martinez and Jeremiah Saylae},
title = {A Review of Tangential Flow Filtration: Process Development and Applications in the Pharmaceutical Industry},
journal = {Organic Process Research and Development},
year = {2023},
volume = {27},
publisher = {American Chemical Society (ACS)},
month = {mar},
url = {https://pubs.acs.org/doi/10.1021/acs.oprd.2c00291},
number = {4},
pages = {571--591},
doi = {10.1021/acs.oprd.2c00291}
}
Cite this
MLA
Copy
Agrawal, Paridhi, et al. “A Review of Tangential Flow Filtration: Process Development and Applications in the Pharmaceutical Industry.” Organic Process Research and Development, vol. 27, no. 4, Mar. 2023, pp. 571-591. https://pubs.acs.org/doi/10.1021/acs.oprd.2c00291.