Organic Process Research and Development, volume 22, issue 2, pages 166-172
Concise Synthesis of Versatile Imidazo[5,1-f][1,2,4]triazin-4(3H)-ones
1
Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States
|
2
Wuxi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China
|
Publication type: Journal Article
Publication date: 2018-01-11
Q1
Q1
SJR: 0.900
CiteScore: 6.9
Impact factor: 3.1
ISSN: 10836160, 1520586X
Organic Chemistry
Physical and Theoretical Chemistry
Abstract
The synthesis of a series of imidazo[5,1-f][1,2,4]triazin-4(3H)-ones was developed from starting imidazoles in three linear steps. The synthetic sequence began with an electrophilic amination and thus a rigorous campaign to identify safe reagent and reaction conditions was performed to ensure safety for preparation of these versatile intermediates on large scales. Functionalizations at the key positions on these substrates were exemplified to demonstrate ability to perform late-stage diversification for efficient SAR discovery.
Top-30
Journals
|
1
|
|
|
Tetrahedron Letters
1 publication, 14.29%
|
|
|
Journal of Organic Chemistry
1 publication, 14.29%
|
|
|
Journal of Medicinal Chemistry
1 publication, 14.29%
|
|
|
ACS Medicinal Chemistry Letters
1 publication, 14.29%
|
|
|
Organic Letters
1 publication, 14.29%
|
|
|
Organic Process Research and Development
1 publication, 14.29%
|
|
|
1
|
Publishers
|
1
2
3
4
5
|
|
|
American Chemical Society (ACS)
5 publications, 71.43%
|
|
|
Elsevier
1 publication, 14.29%
|
|
|
1
2
3
4
5
|
- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Tran T. P. et al. Concise Synthesis of Versatile Imidazo[5,1-f][1,2,4]triazin-4(3H)-ones // Organic Process Research and Development. 2018. Vol. 22. No. 2. pp. 166-172.
GOST all authors (up to 50)
Copy
Tran T. P., Fisher E. L., Wright A. S., Jiao Y. Concise Synthesis of Versatile Imidazo[5,1-f][1,2,4]triazin-4(3H)-ones // Organic Process Research and Development. 2018. Vol. 22. No. 2. pp. 166-172.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.oprd.7b00333
UR - https://doi.org/10.1021/acs.oprd.7b00333
TI - Concise Synthesis of Versatile Imidazo[5,1-f][1,2,4]triazin-4(3H)-ones
T2 - Organic Process Research and Development
AU - Tran, Tuan P
AU - Fisher, Ethan L
AU - Wright, Ann S
AU - Jiao, Yang
PY - 2018
DA - 2018/01/11
PB - American Chemical Society (ACS)
SP - 166-172
IS - 2
VL - 22
SN - 1083-6160
SN - 1520-586X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Tran,
author = {Tuan P Tran and Ethan L Fisher and Ann S Wright and Yang Jiao},
title = {Concise Synthesis of Versatile Imidazo[5,1-f][1,2,4]triazin-4(3H)-ones},
journal = {Organic Process Research and Development},
year = {2018},
volume = {22},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/acs.oprd.7b00333},
number = {2},
pages = {166--172},
doi = {10.1021/acs.oprd.7b00333}
}
Cite this
MLA
Copy
Tran, Tuan P., et al. “Concise Synthesis of Versatile Imidazo[5,1-f][1,2,4]triazin-4(3H)-ones.” Organic Process Research and Development, vol. 22, no. 2, Jan. 2018, pp. 166-172. https://doi.org/10.1021/acs.oprd.7b00333.