From Industrial Method to the Use of Silylated P(III) Reagents for the Synthesis of Relevant Phosphonylated Molecules
Publication type: Journal Article
Publication date: 2020-01-23
scimago Q1
wos Q1
SJR: 0.865
CiteScore: 5.4
Impact factor: 3.5
ISSN: 10836160, 1520586X
Organic Chemistry
Physical and Theoretical Chemistry
Abstract
Phosphonates and its derivatives widely represent important pharmacophores in various classes of therapeutic agents from antivirals to antibiotics. Among these phosphonylated compounds, 1-hydroxymethylene-1,1-bisphosphonates (HMBPs) have occupied a very important place for thirty years now and are currently used in medicine for their inhibitory properties of bone resorption. HMBPs also exhibit direct and indirect antitumor effects in vitro against a broad variety of tumor cell lines, including melanoma, mesothelioma, prostate and breast, lung and myeloma cancer cells. This review will discuss the various syntheses of bisphosphonates with the goal of illustrating their potential interest for the development of therapeutic agents. We will also disclose our latest achievements in phosphinate chemistry.
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16
Total citations:
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Citations from 2025:
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(18.75%)
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GOST
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Dussart J. et al. From Industrial Method to the Use of Silylated P(III) Reagents for the Synthesis of Relevant Phosphonylated Molecules // Organic Process Research and Development. 2020. Vol. 24. No. 5. pp. 637-651.
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Dussart J., Deschamp J., Migianu-Griffoni E., Lecouvey M. From Industrial Method to the Use of Silylated P(III) Reagents for the Synthesis of Relevant Phosphonylated Molecules // Organic Process Research and Development. 2020. Vol. 24. No. 5. pp. 637-651.
Cite this
RIS
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TY - JOUR
DO - 10.1021/acs.oprd.9b00490
UR - https://doi.org/10.1021/acs.oprd.9b00490
TI - From Industrial Method to the Use of Silylated P(III) Reagents for the Synthesis of Relevant Phosphonylated Molecules
T2 - Organic Process Research and Development
AU - Dussart, Jade
AU - Deschamp, Julia
AU - Migianu-Griffoni, E.
AU - Lecouvey, Marc
PY - 2020
DA - 2020/01/23
PB - American Chemical Society (ACS)
SP - 637-651
IS - 5
VL - 24
SN - 1083-6160
SN - 1520-586X
ER -
Cite this
BibTex (up to 50 authors)
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@article{2020_Dussart,
author = {Jade Dussart and Julia Deschamp and E. Migianu-Griffoni and Marc Lecouvey},
title = {From Industrial Method to the Use of Silylated P(III) Reagents for the Synthesis of Relevant Phosphonylated Molecules},
journal = {Organic Process Research and Development},
year = {2020},
volume = {24},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/acs.oprd.9b00490},
number = {5},
pages = {637--651},
doi = {10.1021/acs.oprd.9b00490}
}
Cite this
MLA
Copy
Dussart, Jade, et al. “From Industrial Method to the Use of Silylated P(III) Reagents for the Synthesis of Relevant Phosphonylated Molecules.” Organic Process Research and Development, vol. 24, no. 5, Jan. 2020, pp. 637-651. https://doi.org/10.1021/acs.oprd.9b00490.