Copper-Catalyzed Selective Arylation of Nitriles with Cyclic Diaryl Iodonium Salts: Direct Access to Structurally Diversified Diarylmethane Amides with Potential Neuroprotective and Anticancer Activities.
Publication type: Journal Article
Publication date: 2020-07-17
scimago Q1
wos Q1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
PubMed ID:
32677838
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
A novel, simple, and high-yielding approach for the preparation of diarylmethane amide derivatives has been developed by reacting cyclic diaryl iodonium salts with nitriles using CuCl as a catalyst. The procedure is efficient with high atom economy and a wide substrate range. Importantly, selective arylation of nitriles was obtained without affecting the phenyl amino/hydroxyl groups. Furthermore, two of the diarylmethane amides (3k, 3s) displayed excellent neuroprotective and anticancer activities.
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Total citations:
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Citations from 2024:
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(20.84%)
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GOST
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Peng X. et al. Copper-Catalyzed Selective Arylation of Nitriles with Cyclic Diaryl Iodonium Salts: Direct Access to Structurally Diversified Diarylmethane Amides with Potential Neuroprotective and Anticancer Activities. // Organic Letters. 2020. Vol. 22. No. 15. pp. 5789-5795.
GOST all authors (up to 50)
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Peng X., Sun Z., Kuang P., Li L., Chen J., Chen J. Copper-Catalyzed Selective Arylation of Nitriles with Cyclic Diaryl Iodonium Salts: Direct Access to Structurally Diversified Diarylmethane Amides with Potential Neuroprotective and Anticancer Activities. // Organic Letters. 2020. Vol. 22. No. 15. pp. 5789-5795.
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RIS
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TY - JOUR
DO - 10.1021/acs.orglett.0c01829
UR - https://doi.org/10.1021/acs.orglett.0c01829
TI - Copper-Catalyzed Selective Arylation of Nitriles with Cyclic Diaryl Iodonium Salts: Direct Access to Structurally Diversified Diarylmethane Amides with Potential Neuroprotective and Anticancer Activities.
T2 - Organic Letters
AU - Peng, Xiaopeng
AU - Sun, Zhiqiang
AU - Kuang, Peihua
AU - Li, Ling
AU - Chen, Jingxuan
AU - Chen, Jianjun
PY - 2020
DA - 2020/07/17
PB - American Chemical Society (ACS)
SP - 5789-5795
IS - 15
VL - 22
PMID - 32677838
SN - 1523-7060
SN - 1523-7052
ER -
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BibTex (up to 50 authors)
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@article{2020_Peng,
author = {Xiaopeng Peng and Zhiqiang Sun and Peihua Kuang and Ling Li and Jingxuan Chen and Jianjun Chen},
title = {Copper-Catalyzed Selective Arylation of Nitriles with Cyclic Diaryl Iodonium Salts: Direct Access to Structurally Diversified Diarylmethane Amides with Potential Neuroprotective and Anticancer Activities.},
journal = {Organic Letters},
year = {2020},
volume = {22},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://doi.org/10.1021/acs.orglett.0c01829},
number = {15},
pages = {5789--5795},
doi = {10.1021/acs.orglett.0c01829}
}
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MLA
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Peng, Xiaopeng, et al. “Copper-Catalyzed Selective Arylation of Nitriles with Cyclic Diaryl Iodonium Salts: Direct Access to Structurally Diversified Diarylmethane Amides with Potential Neuroprotective and Anticancer Activities..” Organic Letters, vol. 22, no. 15, Jul. 2020, pp. 5789-5795. https://doi.org/10.1021/acs.orglett.0c01829.