, volume 24 , issue 12 , pages 2310-2314

Direct Synthesis of Paracetamol via Site-Selective Electrochemical Ritter-type C–H Amination of Phenol

Irshad Maajid Taily ¹

Debarshi Saha ¹

Prabal Banerjee ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Department of Chemistry, Indian Institute of Technology Ropar, Lab no. 406, S. S. Bhatnagar Block, Rupnagar, Punjab 140001, India |

Publication type: Journal Article

Publication date: 2022-03-21

American Chemical Society (ACS)

Organic Letters

scimago Q1

wos Q1

SJR: 1.235

CiteScore: 8.7

Impact factor: 5.0

ISSN: 15237060, 15237052

DOI: 10.1021/acs.orglett.2c00439

Copy DOI

PubMed ID: 35312329

Organic Chemistry

Biochemistry

Physical and Theoretical Chemistry

Abstract

The synthesis of paracetamol still relies on multistep protocols involving the utilization of a stoichiometric amount of oxidizing/reducing or other corrosive agents. Herein we report a regioselective electrochemical Ritter-type reaction at the C(sp2)-H of unprotected phenol toward the environmentally benign and direct synthesis of paracetamol. The reaction proceeds under exogenous oxidant- and catalyst-free conditions. The protocol is scalable, can be deployed to a variety of phenols, and offers a sustainable alternative for the synthesis of paracetamol.

Found

4 citations

Budnikova Yulia

DSc in Chemistry, professor

258 publications, 4 500 citations, 54 reviews

h-index: 34

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Kazan Scientific Center of the Russian Academy of Sciences

Research interests

C-H functionalization

Catalysis

Charge transfer

Chemistry of organoelement compounds

2 citations

Babaeva Olga

PhD in Chemistry

56 publications, 438 citations

h-index: 12

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Organic Chemistry

Physical Chemistry

2 citations

Bashirova Ekaterina

5 publications, 13 citations

h-index: 2

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Kazan Scientific Center of the Russian Academy of Sciences

1 citation

Babaev Vasily

PhD in Chemistry, associate professor

81 publications, 931 citations

h-index: 17

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Mass Spectrometry

1 citation

Medvedev Michael

PhD in Physics and Mathematics, associate professor

85 publications, 2 068 citations, 7 reviews

h-index: 19

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

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GOST |

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GOST Copy

Taily I. M., Saha D., Banerjee P. Direct Synthesis of Paracetamol via Site-Selective Electrochemical Ritter-type C–H Amination of Phenol // Organic Letters. 2022. Vol. 24. No. 12. pp. 2310-2314.

GOST all authors (up to 50) Copy

Taily I. M., Saha D., Banerjee P. Direct Synthesis of Paracetamol via Site-Selective Electrochemical Ritter-type C–H Amination of Phenol // Organic Letters. 2022. Vol. 24. No. 12. pp. 2310-2314.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1021/acs.orglett.2c00439

UR - https://doi.org/10.1021/acs.orglett.2c00439

TI - Direct Synthesis of Paracetamol via Site-Selective Electrochemical Ritter-type C–H Amination of Phenol

T2 - Organic Letters

AU - Taily, Irshad Maajid

AU - Saha, Debarshi

AU - Banerjee, Prabal

PY - 2022

DA - 2022/03/21

PB - American Chemical Society (ACS)

SP - 2310-2314

IS - 12

VL - 24

PMID - 35312329

SN - 1523-7060

SN - 1523-7052

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2022_Taily,

author = {Irshad Maajid Taily and Debarshi Saha and Prabal Banerjee},

title = {Direct Synthesis of Paracetamol via Site-Selective Electrochemical Ritter-type C–H Amination of Phenol},

journal = {Organic Letters},

year = {2022},

volume = {24},

publisher = {American Chemical Society (ACS)},

month = {mar},

url = {https://doi.org/10.1021/acs.orglett.2c00439},

number = {12},

pages = {2310--2314},

doi = {10.1021/acs.orglett.2c00439}

}

MLA

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MLA Copy

Taily, Irshad Maajid, et al. “Direct Synthesis of Paracetamol via Site-Selective Electrochemical Ritter-type C–H Amination of Phenol.” Organic Letters, vol. 24, no. 12, Mar. 2022, pp. 2310-2314. https://doi.org/10.1021/acs.orglett.2c00439.

Publisher

American Chemical Society (ACS)

Journal

Organic Letters

scimago Q1

wos Q1

SJR

1.235

CiteScore

8.7

Impact factor

5.0

ISSN

15237060 (Print)

15237052 (Electronic)