Organic Letters, volume 24, issue 9, pages 1859-1864
Copper-Catalyzed Divergent C–H Functionalization Reaction of Quinoxalin-2(1H)-ones and Alkynes Controlled by N1-Substituents for the Synthesis of (Z)-Enaminones and Furo[2,3-b]quinoxalines
Guang Yang
1
,
Zhicheng Xiong
1
,
Hongsheng Nie
1
,
Meiqin He
1
,
Qiong Feng
1
,
Xuan Li
1
,
Huabin Huang
1
,
Shoucai Wang
1
,
Fanghua Ji
1
,
Publication type: Journal Article
Publication date: 2022-02-28
Journal:
Organic Letters
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.2
ISSN: 15237060, 15237052
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
With control by N1-substituents, the switchable divergent C-H functionalization reaction of quinoxalin-2(1H)-ones is achieved for the synthesis of (Z)-enaminones and furo[2,3-b]quinoxalines using the combination of a copper catalyst and an oxidant. This new protocol features mild reaction conditions, readily available materials, and a broad substrate scope. Gram-scale and mechanistic studies were also investigated. Furthermore, the desired products exhibited excellent antitumor activity against A549, HepG-2, MCF-7, and HeLa cells, which were tested by MTT assay.
Top-30
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Journal of Organic Chemistry
4 publications, 44.44%
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1 publication, 11.11%
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Progress in Heterocyclic Chemistry
1 publication, 11.11%
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New Journal of Chemistry
1 publication, 11.11%
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Chemistry - A European Journal
1 publication, 11.11%
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Synthetic Communications
1 publication, 11.11%
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4
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Citations by publishers
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5
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American Chemical Society (ACS)
5 publications, 55.56%
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Elsevier
1 publication, 11.11%
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Royal Society of Chemistry (RSC)
1 publication, 11.11%
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Wiley
1 publication, 11.11%
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Taylor & Francis
1 publication, 11.11%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Yang G. et al. Copper-Catalyzed Divergent C–H Functionalization Reaction of Quinoxalin-2(1H)-ones and Alkynes Controlled by N1-Substituents for the Synthesis of (Z)-Enaminones and Furo[2,3-b]quinoxalines // Organic Letters. 2022. Vol. 24. No. 9. pp. 1859-1864.
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Yang G., Xiong Z., Nie H., He M., Feng Q., Li X., Huang H., Wang S., Ji F., Jiang G. Copper-Catalyzed Divergent C–H Functionalization Reaction of Quinoxalin-2(1H)-ones and Alkynes Controlled by N1-Substituents for the Synthesis of (Z)-Enaminones and Furo[2,3-b]quinoxalines // Organic Letters. 2022. Vol. 24. No. 9. pp. 1859-1864.
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TY - JOUR
DO - 10.1021/acs.orglett.2c00454
UR - https://doi.org/10.1021/acs.orglett.2c00454
TI - Copper-Catalyzed Divergent C–H Functionalization Reaction of Quinoxalin-2(1H)-ones and Alkynes Controlled by N1-Substituents for the Synthesis of (Z)-Enaminones and Furo[2,3-b]quinoxalines
T2 - Organic Letters
AU - Yang, Guang
AU - Xiong, Zhicheng
AU - Nie, Hongsheng
AU - He, Meiqin
AU - Feng, Qiong
AU - Li, Xuan
AU - Huang, Huabin
AU - Wang, Shoucai
AU - Ji, Fanghua
AU - Jiang, Guangbin
PY - 2022
DA - 2022/02/28 00:00:00
PB - American Chemical Society (ACS)
SP - 1859-1864
IS - 9
VL - 24
SN - 1523-7060
SN - 1523-7052
ER -
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@article{2022_Yang,
author = {Guang Yang and Zhicheng Xiong and Hongsheng Nie and Meiqin He and Qiong Feng and Xuan Li and Huabin Huang and Shoucai Wang and Fanghua Ji and Guangbin Jiang},
title = {Copper-Catalyzed Divergent C–H Functionalization Reaction of Quinoxalin-2(1H)-ones and Alkynes Controlled by N1-Substituents for the Synthesis of (Z)-Enaminones and Furo[2,3-b]quinoxalines},
journal = {Organic Letters},
year = {2022},
volume = {24},
publisher = {American Chemical Society (ACS)},
month = {feb},
url = {https://doi.org/10.1021/acs.orglett.2c00454},
number = {9},
pages = {1859--1864},
doi = {10.1021/acs.orglett.2c00454}
}
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MLA
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Yang, Guang, et al. “Copper-Catalyzed Divergent C–H Functionalization Reaction of Quinoxalin-2(1H)-ones and Alkynes Controlled by N1-Substituents for the Synthesis of (Z)-Enaminones and Furo[2,3-b]quinoxalines.” Organic Letters, vol. 24, no. 9, Feb. 2022, pp. 1859-1864. https://doi.org/10.1021/acs.orglett.2c00454.