The Discovery of Quinoxaline-Based Metathesis Catalysts from Synthesis of Grazoprevir (MK-5172)
Michael J. Williams
1
,
Jongrock Kong
1
,
Cheol K Chung
1
,
Andrew Brunskill
1
,
Louis Charles Campeau
1
,
Mark Mclaughlin
1
1
Department of Process and
Analytical Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065, United States
|
Publication type: Journal Article
Publication date: 2016-04-28
scimago Q1
wos Q1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
PubMed ID:
27123552
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
Olefin metathesis (OM) is a reliable and practical synthetic methodology for challenging carbon-carbon bond formations. While existing catalysts can effect many of these transformations, the synthesis and development of new catalysts is essential to increase the application breadth of OM and to achieve improved catalyst activity. The unexpected initial discovery of a novel olefin metathesis catalyst derived from synthetic efforts toward the HCV therapeutic agent grazoprevir (MK-5172) is described. This initial finding has evolved into a class of tunable, shelf-stable ruthenium OM catalysts that are easily prepared and exhibit unique catalytic activity.
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26
Total citations:
26
Citations from 2024:
4
(15.39%)
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MLA
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GOST
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Williams M. J. et al. The Discovery of Quinoxaline-Based Metathesis Catalysts from Synthesis of Grazoprevir (MK-5172) // Organic Letters. 2016. Vol. 18. No. 9. pp. 1952-1955.
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Williams M. J., Kong J., Chung C. K., Brunskill A., Campeau L. C., Mclaughlin M. The Discovery of Quinoxaline-Based Metathesis Catalysts from Synthesis of Grazoprevir (MK-5172) // Organic Letters. 2016. Vol. 18. No. 9. pp. 1952-1955.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.orglett.6b00070
UR - https://doi.org/10.1021/acs.orglett.6b00070
TI - The Discovery of Quinoxaline-Based Metathesis Catalysts from Synthesis of Grazoprevir (MK-5172)
T2 - Organic Letters
AU - Williams, Michael J.
AU - Kong, Jongrock
AU - Chung, Cheol K
AU - Brunskill, Andrew
AU - Campeau, Louis Charles
AU - Mclaughlin, Mark
PY - 2016
DA - 2016/04/28
PB - American Chemical Society (ACS)
SP - 1952-1955
IS - 9
VL - 18
PMID - 27123552
SN - 1523-7060
SN - 1523-7052
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Williams,
author = {Michael J. Williams and Jongrock Kong and Cheol K Chung and Andrew Brunskill and Louis Charles Campeau and Mark Mclaughlin},
title = {The Discovery of Quinoxaline-Based Metathesis Catalysts from Synthesis of Grazoprevir (MK-5172)},
journal = {Organic Letters},
year = {2016},
volume = {18},
publisher = {American Chemical Society (ACS)},
month = {apr},
url = {https://doi.org/10.1021/acs.orglett.6b00070},
number = {9},
pages = {1952--1955},
doi = {10.1021/acs.orglett.6b00070}
}
Cite this
MLA
Copy
Williams, Michael J., et al. “The Discovery of Quinoxaline-Based Metathesis Catalysts from Synthesis of Grazoprevir (MK-5172).” Organic Letters, vol. 18, no. 9, Apr. 2016, pp. 1952-1955. https://doi.org/10.1021/acs.orglett.6b00070.