Organic Letters

, том 18 , издание 14 , страницы 3366-3369

Developing a Biocascade Process: Concurrent Ketone Reduction-Nitrile Hydrolysis of 2-Oxocycloalkanecarbonitriles.

Тип публикации: Journal Article

Дата публикации: 2016-06-30

American Chemical Society (ACS)

Organic Letters

scimago Q1

wos Q1

white level БС1

SJR: 1.235

CiteScore: 8.7

Impact factor: 5

ISSN: 15237060, 15237052

DOI: 10.1021/acs.orglett.6b01510

Скопировать DOI

PubMed ID: 27357900

Organic Chemistry

Biochemistry

Physical and Theoretical Chemistry

Краткое описание

A stereoselective bioreduction of 2-oxocycloalkanecarbonitriles was concurrently coupled to a whole cell-catalyzed nitrile hydrolysis in one-pot. The first step, mediated by ketoreductases, involved a dynamic reductive kinetic resolution, which led to 2-hydroxycycloalkanenitriles in very high enantio- and diastereomeric ratios. Then, the simultaneous exposure to nitrile hydratase and amidase from whole cells of Rhodococcus rhodochrous provided the corresponding 2-hydroxycycloalkanecarboxylic acids with excellent overall yield and optical purity for the all-enzymatic cascade.

Для доступа к списку цитирований публикации необходимо авторизоваться.

Войти с ORCID

Для доступа к списку профилей, цитирующих публикацию, необходимо авторизоваться.

Войти с ORCID

Топ-30

Журналы

	1 2 3
ChemCatChem	ChemCatChem, 3, 15% ChemCatChem 3 публикации, 15%
ACS Catalysis	ACS Catalysis, 3, 15% ACS Catalysis 3 публикации, 15%
Tetrahedron Letters	Tetrahedron Letters, 1, 5% Tetrahedron Letters 1 публикация, 5%
Frontiers in Bioengineering and Biotechnology	Frontiers in Bioengineering and Biotechnology, 1, 5% Frontiers in Bioengineering and Biotechnology 1 публикация, 5%
Monatshefte fur Chemie	Monatshefte fur Chemie, 1, 5% Monatshefte fur Chemie 1 публикация, 5%
Journal of Organometallic Chemistry	Journal of Organometallic Chemistry, 1, 5% Journal of Organometallic Chemistry 1 публикация, 5%
Advanced Synthesis and Catalysis	Advanced Synthesis and Catalysis, 1, 5% Advanced Synthesis and Catalysis 1 публикация, 5%
Chemistry - A European Journal	Chemistry - A European Journal, 1, 5% Chemistry - A European Journal 1 публикация, 5%
European Journal of Inorganic Chemistry	European Journal of Inorganic Chemistry, 1, 5% European Journal of Inorganic Chemistry 1 публикация, 5%
Chemical Reviews	Chemical Reviews, 1, 5% Chemical Reviews 1 публикация, 5%
Natural Product Reports	Natural Product Reports, 1, 5% Natural Product Reports 1 публикация, 5%
Green Chemistry	Green Chemistry, 1, 5% Green Chemistry 1 публикация, 5%
Organic and Biomolecular Chemistry	Organic and Biomolecular Chemistry, 1, 5% Organic and Biomolecular Chemistry 1 публикация, 5%
Chemical Society Reviews	Chemical Society Reviews, 1, 5% Chemical Society Reviews 1 публикация, 5%
	1 2 3

Издатели

	1 2 3 4 5 6 7
Wiley	Wiley, 7, 35% Wiley 7 публикаций, 35%
American Chemical Society (ACS)	American Chemical Society (ACS), 4, 20% American Chemical Society (ACS) 4 публикации, 20%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 4, 20% Royal Society of Chemistry (RSC) 4 публикации, 20%
Elsevier	Elsevier, 3, 15% Elsevier 3 публикации, 15%
Frontiers Media S.A.	Frontiers Media S.A., 1, 5% Frontiers Media S.A. 1 публикация, 5%
Springer Nature	Springer Nature, 1, 5% Springer Nature 1 публикация, 5%
	1 2 3 4 5 6 7

Мы не учитываем публикации, у которых нет DOI.
Статистика публикаций обновляется еженедельно.

Вы ученый?

Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.

Войти с ORCID

Метрики

Цитировать

ГОСТ |

Цитировать

ГОСТ Скопировать

Liardo E. et al. Developing a Biocascade Process: Concurrent Ketone Reduction-Nitrile Hydrolysis of 2-Oxocycloalkanecarbonitriles. // Organic Letters. 2016. Vol. 18. No. 14. pp. 3366-3369.

ГОСТ со всеми авторами (до 50) Скопировать

Liardo E., Ríos Lombardía N., Morís F., González-Sabı́n J., Rebolledo F. Developing a Biocascade Process: Concurrent Ketone Reduction-Nitrile Hydrolysis of 2-Oxocycloalkanecarbonitriles. // Organic Letters. 2016. Vol. 18. No. 14. pp. 3366-3369.

RIS |

Цитировать

RIS Скопировать

TY - JOUR

DO - 10.1021/acs.orglett.6b01510

UR - https://doi.org/10.1021/acs.orglett.6b01510

TI - Developing a Biocascade Process: Concurrent Ketone Reduction-Nitrile Hydrolysis of 2-Oxocycloalkanecarbonitriles.

T2 - Organic Letters

AU - Liardo, Elisa

AU - Ríos Lombardía, Nicolás

AU - Morís, Francisco

AU - González-Sabı́n, Javier

AU - Rebolledo, Francisca

PY - 2016

DA - 2016/06/30

PB - American Chemical Society (ACS)

SP - 3366-3369

IS - 14

VL - 18

PMID - 27357900

SN - 1523-7060

SN - 1523-7052

ER -

BibTex |

Цитировать

BibTex (до 50 авторов) Скопировать

@article{2016_Liardo,

author = {Elisa Liardo and Nicolás Ríos Lombardía and Francisco Morís and Javier González-Sabı́n and Francisca Rebolledo},

title = {Developing a Biocascade Process: Concurrent Ketone Reduction-Nitrile Hydrolysis of 2-Oxocycloalkanecarbonitriles.},

journal = {Organic Letters},

year = {2016},

volume = {18},

publisher = {American Chemical Society (ACS)},

month = {jun},

url = {https://doi.org/10.1021/acs.orglett.6b01510},

number = {14},

pages = {3366--3369},

doi = {10.1021/acs.orglett.6b01510}

}

MLA

Цитировать

MLA Скопировать

Liardo, Elisa, et al. “Developing a Biocascade Process: Concurrent Ketone Reduction-Nitrile Hydrolysis of 2-Oxocycloalkanecarbonitriles..” Organic Letters, vol. 18, no. 14, Jun. 2016, pp. 3366-3369. https://doi.org/10.1021/acs.orglett.6b01510.