Organic Letters

, volume 19 , issue 18 , pages 4968-4971

A One-Pot Construction of Halogenated Trifluoromethylated Pyrroles through NXS (X = Br, I) Triggered Cascade

Chaoqian Huang ¹

Zeng Yu ¹

Huayu Cheng ¹

Anjing Hu ¹

Lu Liu ¹

Yuanjing Xiao ¹

Junliang Zhang ^{1, 2}

Hide authors affiliations Show authors affiliations: 2 affiliations

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, PR China |

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, CAS. 345 Lingling Road, Shanghai 200032, PR China |

Publication type: Journal Article

Publication date: 2017-09-01

American Chemical Society (ACS)

Organic Letters

scimago Q1

wos Q1

SJR: 1.235

CiteScore: 8.7

Impact factor: 5.0

ISSN: 15237060, 15237052

DOI: 10.1021/acs.orglett.7b02427

Copy DOI

PubMed ID: 28862450

Organic Chemistry

Biochemistry

Physical and Theoretical Chemistry

Abstract

An easy two-step, one-pot synthesis of halogenated trifluoromethylated pyrroles is realized by sequential intermolecular hydroamination reaction of 2-trifluoromethyl-1,3-enynes with aliphatic primary amines under mild reaction conditions, and NXS mediated oxidative cyclization of the hydroamination product. The salient features of this method include mild conditions, readily available starting materials, general substrate scope, high efficiency and synthetic utility of the products.

Found

1 citation

Novikov Mikhail

DSc in Chemistry, associate professor

218 publications, 4 210 citations, 54 reviews

h-index: 33

Saint Petersburg State University

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Huang C. et al. A One-Pot Construction of Halogenated Trifluoromethylated Pyrroles through NXS (X = Br, I) Triggered Cascade // Organic Letters. 2017. Vol. 19. No. 18. pp. 4968-4971.

GOST all authors (up to 50) Copy

Huang C., Yu Z., Cheng H., Hu A., Liu L., Xiao Y., Zhang J. A One-Pot Construction of Halogenated Trifluoromethylated Pyrroles through NXS (X = Br, I) Triggered Cascade // Organic Letters. 2017. Vol. 19. No. 18. pp. 4968-4971.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/acs.orglett.7b02427

UR - https://doi.org/10.1021/acs.orglett.7b02427

TI - A One-Pot Construction of Halogenated Trifluoromethylated Pyrroles through NXS (X = Br, I) Triggered Cascade

T2 - Organic Letters

AU - Huang, Chaoqian

AU - Yu, Zeng

AU - Cheng, Huayu

AU - Hu, Anjing

AU - Liu, Lu

AU - Xiao, Yuanjing

AU - Zhang, Junliang

PY - 2017

DA - 2017/09/01

PB - American Chemical Society (ACS)

SP - 4968-4971

IS - 18

VL - 19

PMID - 28862450

SN - 1523-7060

SN - 1523-7052

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2017_Huang,

author = {Chaoqian Huang and Zeng Yu and Huayu Cheng and Anjing Hu and Lu Liu and Yuanjing Xiao and Junliang Zhang},

title = {A One-Pot Construction of Halogenated Trifluoromethylated Pyrroles through NXS (X = Br, I) Triggered Cascade},

journal = {Organic Letters},

year = {2017},

volume = {19},

publisher = {American Chemical Society (ACS)},

month = {sep},

url = {https://doi.org/10.1021/acs.orglett.7b02427},

number = {18},

pages = {4968--4971},

doi = {10.1021/acs.orglett.7b02427}

}

MLA

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MLA Copy

Huang, Chaoqian, et al. “A One-Pot Construction of Halogenated Trifluoromethylated Pyrroles through NXS (X = Br, I) Triggered Cascade.” Organic Letters, vol. 19, no. 18, Sep. 2017, pp. 4968-4971. https://doi.org/10.1021/acs.orglett.7b02427.

Publisher

American Chemical Society (ACS)

Journal

Organic Letters

scimago Q1

wos Q1

SJR

1.235

CiteScore

8.7

Impact factor

5.0

ISSN

15237060 (Print)

15237052 (Electronic)