Organic Letters

, volume 19 , issue 18 , pages 4988-4991

Asymmetric Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in Situ as Activator

Muwang Chen ¹

Yue Ru Ji ¹

Jie Wang ¹

Qingan Chen ¹

Lei Shi ¹

Yonggui Zhou ^{1, 2}

Hide authors affiliations Show authors affiliations: 2 affiliations

State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China |

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China |

Publication type: Journal Article

Publication date: 2017-09-07

American Chemical Society (ACS)

Organic Letters

scimago Q1

wos Q1

SJR: 1.235

CiteScore: 8.7

Impact factor: 5.0

ISSN: 15237060, 15237052

DOI: 10.1021/acs.orglett.7b02502

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PubMed ID: 28879769

Organic Chemistry

Biochemistry

Physical and Theoretical Chemistry

Abstract

By employing halogenide trichloroisocyanuric acid as a traceless activation reagent, a general iridium-catalyzed asymmetric hydrogenation of isoquinolines and pyridines is developed with up to 99% ee. This method avoids tedious steps of installation and removal of the activating groups. The mechanism studies indicated that hydrogen halide generated in situ acted as an activator of isoquinolines and pyridines.

Found

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Ivanov Andrey

54 publications, 537 citations

h-index: 12

A.E. Favorsky Irkutsk Institute of Chemistry of the Siberian Branch of the Russian Academy of Sciences

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GOST |

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Chen M. et al. Asymmetric Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in Situ as Activator // Organic Letters. 2017. Vol. 19. No. 18. pp. 4988-4991.

GOST all authors (up to 50) Copy

Chen M., Ji Y. R., Wang J., Chen Q., Shi L., Zhou Y. Asymmetric Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in Situ as Activator // Organic Letters. 2017. Vol. 19. No. 18. pp. 4988-4991.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/acs.orglett.7b02502

UR - https://doi.org/10.1021/acs.orglett.7b02502

TI - Asymmetric Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in Situ as Activator

T2 - Organic Letters

AU - Chen, Muwang

AU - Ji, Yue Ru

AU - Wang, Jie

AU - Chen, Qingan

AU - Shi, Lei

AU - Zhou, Yonggui

PY - 2017

DA - 2017/09/07

PB - American Chemical Society (ACS)

SP - 4988-4991

IS - 18

VL - 19

PMID - 28879769

SN - 1523-7060

SN - 1523-7052

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2017_Chen,

author = {Muwang Chen and Yue Ru Ji and Jie Wang and Qingan Chen and Lei Shi and Yonggui Zhou},

title = {Asymmetric Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in Situ as Activator},

journal = {Organic Letters},

year = {2017},

volume = {19},

publisher = {American Chemical Society (ACS)},

month = {sep},

url = {https://doi.org/10.1021/acs.orglett.7b02502},

number = {18},

pages = {4988--4991},

doi = {10.1021/acs.orglett.7b02502}

}

MLA

Cite this

MLA Copy

Chen, Muwang, et al. “Asymmetric Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in Situ as Activator.” Organic Letters, vol. 19, no. 18, Sep. 2017, pp. 4988-4991. https://doi.org/10.1021/acs.orglett.7b02502.

Publisher

American Chemical Society (ACS)

Journal

Organic Letters

scimago Q1

wos Q1

SJR

1.235

CiteScore

8.7

Impact factor

5.0

ISSN

15237060 (Print)

15237052 (Electronic)