Chemoselective One-Pot Synthesis of Functionalized Amino-azaheterocycles Enabled by COware.
Тип публикации: Journal Article
Дата публикации: 2017-11-14
scimago Q1
wos Q1
БС1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
PubMed ID:
29135268
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Краткое описание
Functionalized bicyclic amino-azaheterocycles are rapidly accessed in a one-pot cross-coupling/reduction sequence enabled by the use of COware. Incompatible reagents are physically separated in a single reaction vessel to effect two chemoselective transformations-Suzuki-Miyaura cross-coupling and heteroarene reduction. The developed method allows access to novel heterocyclic templates, including semisaturated Hedgehog and dual PI3K/mTOR inhibitors, which show enhanced physicochemical properties compared to their unsaturated counterparts.
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ГОСТ
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Clohessy T. A. et al. Chemoselective One-Pot Synthesis of Functionalized Amino-azaheterocycles Enabled by COware. // Organic Letters. 2017. Vol. 19. No. 23. pp. 6368-6371.
ГОСТ со всеми авторами (до 50)
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Clohessy T. A., Roberts A., Manas E. S., Patel V. K., Anderson N. A., Watson A. J. B. Chemoselective One-Pot Synthesis of Functionalized Amino-azaheterocycles Enabled by COware. // Organic Letters. 2017. Vol. 19. No. 23. pp. 6368-6371.
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RIS
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TY - JOUR
DO - 10.1021/acs.orglett.7b03214
UR - https://doi.org/10.1021/acs.orglett.7b03214
TI - Chemoselective One-Pot Synthesis of Functionalized Amino-azaheterocycles Enabled by COware.
T2 - Organic Letters
AU - Clohessy, Thomas A
AU - Roberts, Alastair
AU - Manas, Eric S.
AU - Patel, Vipulkumar K
AU - Anderson, Niall A
AU - Watson, Allan J. B.
PY - 2017
DA - 2017/11/14
PB - American Chemical Society (ACS)
SP - 6368-6371
IS - 23
VL - 19
PMID - 29135268
SN - 1523-7060
SN - 1523-7052
ER -
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@article{2017_Clohessy,
author = {Thomas A Clohessy and Alastair Roberts and Eric S. Manas and Vipulkumar K Patel and Niall A Anderson and Allan J. B. Watson},
title = {Chemoselective One-Pot Synthesis of Functionalized Amino-azaheterocycles Enabled by COware.},
journal = {Organic Letters},
year = {2017},
volume = {19},
publisher = {American Chemical Society (ACS)},
month = {nov},
url = {https://doi.org/10.1021/acs.orglett.7b03214},
number = {23},
pages = {6368--6371},
doi = {10.1021/acs.orglett.7b03214}
}
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MLA
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Clohessy, Thomas A., et al. “Chemoselective One-Pot Synthesis of Functionalized Amino-azaheterocycles Enabled by COware..” Organic Letters, vol. 19, no. 23, Nov. 2017, pp. 6368-6371. https://doi.org/10.1021/acs.orglett.7b03214.