ACS applied materials & interfaces, volume 13, issue 12, pages 14458-14469
Magnetic Nanoparticles as a Tool for Remote DNA Manipulations at a Single-Molecule Level
Nikitin Aleksey A
1, 2
,
Yurenya Anton Yu
2, 3
,
Zatsepin Timofei S.
2, 4
,
Aparin Ilya O
4
,
Чехонин В. П.
5
,
Majouga Alexander G.
1, 2, 6
,
Farle M.
7
,
Wiedwald U.
7
,
Abakumov Maxim A.
1, 5
7
Faculty of Physics and Center for Nanointegration Duisburg-Essen, University of Duisburg-Essen, Duisburg 47057, Germany
|
Publication type: Journal Article
Publication date: 2021-03-19
Journal:
ACS applied materials & interfaces
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 9.5
ISSN: 19448244, 19448252
General Materials Science
Abstract
Remote control of cells and single molecules by magnetic nanoparticles in nonheating external magnetic fields is a perspective approach for many applications such as cancer treatment and enzyme activity regulation. However, the possibility and mechanisms of direct effects of small individual magnetic nanoparticles on such processes in magneto-mechanical experiments still remain unclear. In this work, we have shown remote-controlled mechanical dissociation of short DNA duplexes (18-60 bp) under the influence of nonheating low-frequency alternating magnetic fields using individual 11 nm magnetic nanoparticles. The developed technique allows (1) simultaneous manipulation of millions of individual DNA molecules and (2) evaluation of energies of intermolecular interactions in short DNA duplexes or in other molecules. Finally, we have shown that DNA duplexes dissociation is mediated by mechanical stress and produced by the movement of magnetic nanoparticles in magnetic fields, but not by local overheating. The presented technique opens a new avenue for high-precision manipulation of DNA and generation of biosensors for quantification of energies of intermolecular interaction.
Citations by journals
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1
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Nanomaterials
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Nanomaterials
1 publication, 7.14%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 7.14%
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Magnetochemistry
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Magnetochemistry
1 publication, 7.14%
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Biosensors
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Biosensors
1 publication, 7.14%
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Membranes
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Membranes
1 publication, 7.14%
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Journal of Controlled Release
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Journal of Controlled Release
1 publication, 7.14%
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Materials Today Chemistry
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Materials Today Chemistry
1 publication, 7.14%
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Nanoscale Advances
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Nanoscale Advances
1 publication, 7.14%
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Photonics
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Photonics
1 publication, 7.14%
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ACS Applied Nano Materials
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ACS Applied Nano Materials
1 publication, 7.14%
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Langmuir
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Langmuir
1 publication, 7.14%
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Journal of Functional Biomaterials
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Journal of Functional Biomaterials
1 publication, 7.14%
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Journal of Physical Chemistry Letters
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Journal of Physical Chemistry Letters
1 publication, 7.14%
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Nanoscale
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Nanoscale
1 publication, 7.14%
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1
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Citations by publishers
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1
2
3
4
5
6
7
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
7 publications, 50%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
3 publications, 21.43%
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Elsevier
|
Elsevier
2 publications, 14.29%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
2 publications, 14.29%
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1
2
3
4
5
6
7
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Nikitin A. A. et al. Magnetic Nanoparticles as a Tool for Remote DNA Manipulations at a Single-Molecule Level // ACS applied materials & interfaces. 2021. Vol. 13. No. 12. pp. 14458-14469.
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Nikitin A. A., Yurenya A. Yu., Zatsepin T. S., Aparin I. O., Чехонин В. П., Majouga A. G., Farle M., Wiedwald U., Abakumov M. A. Magnetic Nanoparticles as a Tool for Remote DNA Manipulations at a Single-Molecule Level // ACS applied materials & interfaces. 2021. Vol. 13. No. 12. pp. 14458-14469.
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TY - JOUR
DO - 10.1021/acsami.0c21002
UR - https://doi.org/10.1021%2Facsami.0c21002
TI - Magnetic Nanoparticles as a Tool for Remote DNA Manipulations at a Single-Molecule Level
T2 - ACS applied materials & interfaces
AU - Yurenya, Anton Yu
AU - Nikitin, Aleksey A
AU - Zatsepin, Timofei S.
AU - Aparin, Ilya O
AU - Majouga, Alexander G.
AU - Abakumov, Maxim A.
AU - Чехонин, В. П.
AU - Farle, M.
AU - Wiedwald, U.
PY - 2021
DA - 2021/03/19 00:00:00
PB - American Chemical Society (ACS)
SP - 14458-14469
IS - 12
VL - 13
SN - 1944-8244
SN - 1944-8252
ER -
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@article{2021_Nikitin,
author = {Anton Yu Yurenya and Aleksey A Nikitin and Timofei S. Zatsepin and Ilya O Aparin and Alexander G. Majouga and Maxim A. Abakumov and В. П. Чехонин and M. Farle and U. Wiedwald},
title = {Magnetic Nanoparticles as a Tool for Remote DNA Manipulations at a Single-Molecule Level},
journal = {ACS applied materials & interfaces},
year = {2021},
volume = {13},
publisher = {American Chemical Society (ACS)},
month = {mar},
url = {https://doi.org/10.1021%2Facsami.0c21002},
number = {12},
pages = {14458--14469},
doi = {10.1021/acsami.0c21002}
}
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Nikitin, Aleksey A., et al. “Magnetic Nanoparticles as a Tool for Remote DNA Manipulations at a Single-Molecule Level.” ACS applied materials & interfaces, vol. 13, no. 12, Mar. 2021, pp. 14458-14469. https://doi.org/10.1021%2Facsami.0c21002.