BODIPY-Based Fluorometric Sensor for the Simultaneous Determination of Cys, Hcy, and GSH in Human Serum
Ming Yan Jia
1, 2
,
Li-Ya Niu
3
,
Yu Zhang
1
,
Qingzheng Yang
3
,
Chen-Ho Tung
3
,
Yafeng Guan
1
,
Liang Feng
1
Publication type: Journal Article
Publication date: 2015-03-09
scimago Q1
wos Q1
SJR: 1.921
CiteScore: 14.5
Impact factor: 8.2
ISSN: 19448244, 19448252
PubMed ID:
25699658
General Materials Science
Abstract
Cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) are interconnected and play essential roles for regulating the redox balance of biological processes. However, finding a simple and effective method for the simultaneous determination for these three biothiols in biological systems is always a challenge. In this work, we report a method for the simultaneous quantitative determination of three biothiols in a mixture using a monochlorinated boron dipyrromethene (BODIPY)-based fluorometric sensor. At a specified period of time, after reacting with excess sensor, Hcy and GSH form predominantly sulfur-substituted BODIPY, while Cys generates sulfur-amino-diBODIPY due to a fast substitution-rearrangement-substitution reaction. A significant difference in polarities of these respective major products simplifies their separation by TLC, thus leading to the simultaneous determination of Cys, Hcy, and GSH readily. The sensor was successfully applied for the simultaneous quantitative detection of three biothiols in human serum, and the results were in good agreement with those obtained via high performance liquid chromatography (HPLC).
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161
Total citations:
161
Citations from 2024:
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(10.56%)
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Jia M. Y. et al. BODIPY-Based Fluorometric Sensor for the Simultaneous Determination of Cys, Hcy, and GSH in Human Serum // ACS applied materials & interfaces. 2015. Vol. 7. No. 10. pp. 5907-5914.
GOST all authors (up to 50)
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Jia M. Y., Niu L., Zhang Yu., Yang Q., Tung C., Guan Y., Feng L. BODIPY-Based Fluorometric Sensor for the Simultaneous Determination of Cys, Hcy, and GSH in Human Serum // ACS applied materials & interfaces. 2015. Vol. 7. No. 10. pp. 5907-5914.
Cite this
RIS
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TY - JOUR
DO - 10.1021/acsami.5b00122
UR - https://doi.org/10.1021/acsami.5b00122
TI - BODIPY-Based Fluorometric Sensor for the Simultaneous Determination of Cys, Hcy, and GSH in Human Serum
T2 - ACS applied materials & interfaces
AU - Jia, Ming Yan
AU - Niu, Li-Ya
AU - Zhang, Yu
AU - Yang, Qingzheng
AU - Tung, Chen-Ho
AU - Guan, Yafeng
AU - Feng, Liang
PY - 2015
DA - 2015/03/09
PB - American Chemical Society (ACS)
SP - 5907-5914
IS - 10
VL - 7
PMID - 25699658
SN - 1944-8244
SN - 1944-8252
ER -
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BibTex (up to 50 authors)
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@article{2015_Jia,
author = {Ming Yan Jia and Li-Ya Niu and Yu Zhang and Qingzheng Yang and Chen-Ho Tung and Yafeng Guan and Liang Feng},
title = {BODIPY-Based Fluorometric Sensor for the Simultaneous Determination of Cys, Hcy, and GSH in Human Serum},
journal = {ACS applied materials & interfaces},
year = {2015},
volume = {7},
publisher = {American Chemical Society (ACS)},
month = {mar},
url = {https://doi.org/10.1021/acsami.5b00122},
number = {10},
pages = {5907--5914},
doi = {10.1021/acsami.5b00122}
}
Cite this
MLA
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Jia, Ming Yan, et al. “BODIPY-Based Fluorometric Sensor for the Simultaneous Determination of Cys, Hcy, and GSH in Human Serum.” ACS applied materials & interfaces, vol. 7, no. 10, Mar. 2015, pp. 5907-5914. https://doi.org/10.1021/acsami.5b00122.