Protein-Stabilized Gadolinium Oxide-Gold Nanoclusters Hybrid for Multimodal Imaging and Drug Delivery
1
Research Center
for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Box 332, Shenyang 110189, China
|
2
Institute of Biotechnology, College of
Life and Health Sciences, Northeastern University, Box H006, Shenyang 110189, China
|
Publication type: Journal Article
Publication date: 2017-02-17
scimago Q1
wos Q1
SJR: 1.921
CiteScore: 14.5
Impact factor: 8.2
ISSN: 19448244, 19448252
PubMed ID:
28177224
General Materials Science
Abstract
A protein-stabilized multifunctional theranostic nanoplatform, gadolinium oxide-gold nanoclusters hybrid (Gd2O3-AuNCs), is constructed for multimodal imaging and drug delivery. The Gd2O3-AuNCs nanohybrid is developed by integrating Gd2O3 nanocrystals and gold nanoclusters into bovine serum albumin scaffold as a stabilizer. The nanohybrid exhibits favorable biocompatibility and is capable of enhancing the contrast in magnetic resonance and X-ray computed tomography imaging. Meanwhile, the integrated AuNCs component not only endows the nanohybrid to produce red fluorescence, but also sensitizes the generation of singlet oxygen (1O2) upon near-infrared laser stimulation at 808 nm. Bovine serum albumin surrounding the nanoparticles makes Gd2O3-AuNCs a brilliant carrier for the delivery of indocyanine green (ICG). ICG loading endows the Gd2O3-AuNCs-ICG nanocomposite with a near-infrared fluorescence imaging capability, and improves its photodynamic property and photothermal capability. Ultimately, further experiments have demonstrated that Gd2O3-AuNCs-ICG nanocomposite is a promising theranostic agent for image guided cancer therapy.
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Citations from 2024:
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GOST
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Han L. et al. Protein-Stabilized Gadolinium Oxide-Gold Nanoclusters Hybrid for Multimodal Imaging and Drug Delivery // ACS applied materials & interfaces. 2017. Vol. 9. No. 8. pp. 6941-6949.
GOST all authors (up to 50)
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Han L., Jun-mei X., Xin H., SHU Y., Chen X., Wang J. Protein-Stabilized Gadolinium Oxide-Gold Nanoclusters Hybrid for Multimodal Imaging and Drug Delivery // ACS applied materials & interfaces. 2017. Vol. 9. No. 8. pp. 6941-6949.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acsami.7b00246
UR - https://doi.org/10.1021/acsami.7b00246
TI - Protein-Stabilized Gadolinium Oxide-Gold Nanoclusters Hybrid for Multimodal Imaging and Drug Delivery
T2 - ACS applied materials & interfaces
AU - Han, Lu
AU - Jun-mei, Xia
AU - Xin, Hai
AU - SHU, YANG
AU - Chen, Xuwei
AU - Wang, Jianhua
PY - 2017
DA - 2017/02/17
PB - American Chemical Society (ACS)
SP - 6941-6949
IS - 8
VL - 9
PMID - 28177224
SN - 1944-8244
SN - 1944-8252
ER -
Cite this
BibTex (up to 50 authors)
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@article{2017_Han,
author = {Lu Han and Xia Jun-mei and Hai Xin and YANG SHU and Xuwei Chen and Jianhua Wang},
title = {Protein-Stabilized Gadolinium Oxide-Gold Nanoclusters Hybrid for Multimodal Imaging and Drug Delivery},
journal = {ACS applied materials & interfaces},
year = {2017},
volume = {9},
publisher = {American Chemical Society (ACS)},
month = {feb},
url = {https://doi.org/10.1021/acsami.7b00246},
number = {8},
pages = {6941--6949},
doi = {10.1021/acsami.7b00246}
}
Cite this
MLA
Copy
Han, Lu, et al. “Protein-Stabilized Gadolinium Oxide-Gold Nanoclusters Hybrid for Multimodal Imaging and Drug Delivery.” ACS applied materials & interfaces, vol. 9, no. 8, Feb. 2017, pp. 6941-6949. https://doi.org/10.1021/acsami.7b00246.