Nanoparticle-Delivered 2-PAM for Rat Brain Protection against Paraoxon Central Toxicity
T.N Pashirova
1
,
Irina V. Zueva
1
,
Konstantin A Petrov
1, 2
,
Vasily Babaev
1
,
Evgeny E. Nikolsky
1, 3
,
P. Masson
2
,
Publication type: Journal Article
Publication date: 2017-05-15
scimago Q1
wos Q1
SJR: 1.921
CiteScore: 14.5
Impact factor: 8.2
ISSN: 19448244, 19448252
PubMed ID:
28504886
General Materials Science
Abstract
Solid lipid nanoparticles (SLNs) are among the most promising nanocarriers to target the blood-brain barrier (BBB) for drug delivery to the central nervous system (CNS). Encapsulation of the acetylcholinesterase reactivator, pralidoxime chloride (2-PAM), in SLNs appears to be a suitable strategy for protection against poisoning by organophosphorus agents (OPs) and postexposure treatment. 2-PAM-loaded SLNs were developed for brain targeting and delivery via intravenous (iv) administration. 2-PAM-SLNs displayed a high 2-PAM encapsulation efficiency (∼90%) and loading capacity (maximum 30.8 ± 1%). Drug-loaded particles had a mean hydrodynamic diameter close to 100 nm and high negative zeta potential (-54 to -15 mV). These properties contribute to improve long-term stability of 2-PAM-SLNs when stored both at room temperature (22 °C) and at 4 °C, as well as to longer circulation time in the bloodstream compared to free 2-PAM. Paraoxon-poisoned rats (2 × LD50) were treated with 2-PAM-loaded SLNs at a dose of 2-PAM of 5 mg/kg. 2-PAM-SLNs reactivated 15% of brain AChE activity. Our results confirm the potential use of SLNs loaded with positively charged oximes as a medical countermeasure both for protection against OPs poisoning and for postexposure treatment.
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Total citations:
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Citations from 2024:
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(17%)
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GOST
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Pashirova T. et al. Nanoparticle-Delivered 2-PAM for Rat Brain Protection against Paraoxon Central Toxicity // ACS applied materials & interfaces. 2017. Vol. 9. No. 20. pp. 16922-16932.
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Pashirova T., Zueva I. V., Petrov K. A., Babaev V., Lukashenko S. S., Rizvanov I. Kh., Nikolsky E., Zakharova L. Ya., Masson P., Sinyashin O. G. Nanoparticle-Delivered 2-PAM for Rat Brain Protection against Paraoxon Central Toxicity // ACS applied materials & interfaces. 2017. Vol. 9. No. 20. pp. 16922-16932.
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TY - JOUR
DO - 10.1021/acsami.7b04163
UR - https://doi.org/10.1021/acsami.7b04163
TI - Nanoparticle-Delivered 2-PAM for Rat Brain Protection against Paraoxon Central Toxicity
T2 - ACS applied materials & interfaces
AU - Pashirova, T.N
AU - Zueva, Irina V.
AU - Petrov, Konstantin A
AU - Babaev, Vasily
AU - Lukashenko, Svetlana S
AU - Rizvanov, Ildar Kh
AU - Nikolsky, Evgeny E.
AU - Zakharova, Lucia Ya
AU - Masson, P.
AU - Sinyashin, Oleg G.
PY - 2017
DA - 2017/05/15
PB - American Chemical Society (ACS)
SP - 16922-16932
IS - 20
VL - 9
PMID - 28504886
SN - 1944-8244
SN - 1944-8252
ER -
Cite this
BibTex (up to 50 authors)
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@article{2017_Pashirova,
author = {T.N Pashirova and Irina V. Zueva and Konstantin A Petrov and Vasily Babaev and Svetlana S Lukashenko and Ildar Kh Rizvanov and Evgeny E. Nikolsky and Lucia Ya Zakharova and P. Masson and Oleg G. Sinyashin},
title = {Nanoparticle-Delivered 2-PAM for Rat Brain Protection against Paraoxon Central Toxicity},
journal = {ACS applied materials & interfaces},
year = {2017},
volume = {9},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/acsami.7b04163},
number = {20},
pages = {16922--16932},
doi = {10.1021/acsami.7b04163}
}
Cite this
MLA
Copy
Pashirova, T.N, et al. “Nanoparticle-Delivered 2-PAM for Rat Brain Protection against Paraoxon Central Toxicity.” ACS applied materials & interfaces, vol. 9, no. 20, May. 2017, pp. 16922-16932. https://doi.org/10.1021/acsami.7b04163.