Ferric Hydroxide-Modified Upconversion Nanoparticles for 808 nm NIR-Triggered Synergetic Tumor Therapy with Hypoxia Modulation
Xiao Wu
1
,
Peijian Yan
2
,
Zhaohui Ren
1
,
Yifan Wang
2
,
Xiu-Jun Cai
2
,
Xiaolin Li
1
,
Renren Deng
1
,
Gaorong Han
1
Publication type: Journal Article
Publication date: 2018-12-17
scimago Q1
wos Q1
SJR: 1.921
CiteScore: 14.5
Impact factor: 8.2
ISSN: 19448244, 19448252
PubMed ID:
30556390
General Materials Science
Abstract
The efficacy of dynamic therapy for solid tumors suffers daunting challenges induced by tumor hypoxia. Herein, we report a biocompatible nanosystem containing Fe(OH)3-modified upconversion nanoparticles (UCNPs) for promoting synergetic chemo- and photodynamic therapy with the modulation of tumor hypoxia. In this system, UCNPs convert 808 nm near-infrared excitation to visible photon energy, which stimulates chlorin-e6 photosensitizers to generate toxic reactive oxygen species (ROS) by consumption of dissolved oxygen in cancer cells. Importantly, we employ Fe(OH)3 compounds to enable continuous oxygen generation in cancer cells and, meanwhile, induce extra ROS formation through the Fenton-like reaction. The system consequently improves the tumor treatment efficacy in vitro and in vivo. This study puts forward a novel combinatorial therapeutic platform for tumor microenvironment modulation and enhanced cancer therapy.
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Metrics
48
Total citations:
48
Citations from 2024:
7
(14%)
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MLA
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GOST
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Wu X. et al. Ferric Hydroxide-Modified Upconversion Nanoparticles for 808 nm NIR-Triggered Synergetic Tumor Therapy with Hypoxia Modulation // ACS applied materials & interfaces. 2018. Vol. 11. No. 1. pp. 385-393.
GOST all authors (up to 50)
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Wu X., Yan P., Ren Z., Wang Y., Cai X., Li X., Deng R., Han G. Ferric Hydroxide-Modified Upconversion Nanoparticles for 808 nm NIR-Triggered Synergetic Tumor Therapy with Hypoxia Modulation // ACS applied materials & interfaces. 2018. Vol. 11. No. 1. pp. 385-393.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acsami.8b18427
UR - https://doi.org/10.1021/acsami.8b18427
TI - Ferric Hydroxide-Modified Upconversion Nanoparticles for 808 nm NIR-Triggered Synergetic Tumor Therapy with Hypoxia Modulation
T2 - ACS applied materials & interfaces
AU - Wu, Xiao
AU - Yan, Peijian
AU - Ren, Zhaohui
AU - Wang, Yifan
AU - Cai, Xiu-Jun
AU - Li, Xiaolin
AU - Deng, Renren
AU - Han, Gaorong
PY - 2018
DA - 2018/12/17
PB - American Chemical Society (ACS)
SP - 385-393
IS - 1
VL - 11
PMID - 30556390
SN - 1944-8244
SN - 1944-8252
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Wu,
author = {Xiao Wu and Peijian Yan and Zhaohui Ren and Yifan Wang and Xiu-Jun Cai and Xiaolin Li and Renren Deng and Gaorong Han},
title = {Ferric Hydroxide-Modified Upconversion Nanoparticles for 808 nm NIR-Triggered Synergetic Tumor Therapy with Hypoxia Modulation},
journal = {ACS applied materials & interfaces},
year = {2018},
volume = {11},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021/acsami.8b18427},
number = {1},
pages = {385--393},
doi = {10.1021/acsami.8b18427}
}
Cite this
MLA
Copy
Wu, Xiao, et al. “Ferric Hydroxide-Modified Upconversion Nanoparticles for 808 nm NIR-Triggered Synergetic Tumor Therapy with Hypoxia Modulation.” ACS applied materials & interfaces, vol. 11, no. 1, Dec. 2018, pp. 385-393. https://doi.org/10.1021/acsami.8b18427.
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