Controlling Endosomal Escape Using pH-Responsive Nanoparticles with Tunable Disassembly
Тип публикации: Journal Article
Дата публикации: 2018-06-05
scimago Q1
wos Q2
БС1
SJR: 1.121
CiteScore: 8.1
Impact factor: 5.5
ISSN: 25740970
General Materials Science
Краткое описание
Endosomal escape is a bottleneck in the efficient delivery of therapeutics using nanoparticles; therefore understanding how this property can be optimized is important for achieving better therapeutic outcomes. It has been demonstrated that pH-responsive nanoparticles (pHlexi nanoparticles) have potential to achieve effective escape from the endosomal compartments of the cell. In this paper a library of five pHlexi particles with tunable disassembly pH were synthesized by combining poly(ethylene glycol)-b-poly(2-(diethylamino)ethyl methacrylate) (PEG-b-PDEAEMA) with random copolymers of 2-(diethylamino)ethyl methacrylate and 2-(diisopropylamino)ethyl methacrylate. A series of cellular studies were conducted to investigate the effect of particle composition on in vitro behavior. Endosomal escape was probed using a calcein escape assay in NIH/3T3 fibroblast cells, demonstrating endosomal escape increased with increasing particle concentration. Interestingly, it was shown that endosomal escape was most effic...
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ГОСТ
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Kongkatigumjorn N. et al. Controlling Endosomal Escape Using pH-Responsive Nanoparticles with Tunable Disassembly // ACS Applied Nano Materials. 2018. Vol. 1. No. 7. pp. 3164-3173.
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Kongkatigumjorn N., Smith S. A., Chen M., Fang K., Yang S., Gillies E. M., Johnston A. J., Such G. K. Controlling Endosomal Escape Using pH-Responsive Nanoparticles with Tunable Disassembly // ACS Applied Nano Materials. 2018. Vol. 1. No. 7. pp. 3164-3173.
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RIS
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TY - JOUR
DO - 10.1021/acsanm.8b00338
UR - https://pubs.acs.org/doi/10.1021/acsanm.8b00338
TI - Controlling Endosomal Escape Using pH-Responsive Nanoparticles with Tunable Disassembly
T2 - ACS Applied Nano Materials
AU - Kongkatigumjorn, Nachnicha
AU - Smith, Samuel A
AU - Chen, Moore
AU - Fang, Katie
AU - Yang, Shenglin
AU - Gillies, Elizabeth M.
AU - Johnston, Angus J.
AU - Such, Georgina K.
PY - 2018
DA - 2018/06/05
PB - American Chemical Society (ACS)
SP - 3164-3173
IS - 7
VL - 1
SN - 2574-0970
ER -
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@article{2018_Kongkatigumjorn,
author = {Nachnicha Kongkatigumjorn and Samuel A Smith and Moore Chen and Katie Fang and Shenglin Yang and Elizabeth M. Gillies and Angus J. Johnston and Georgina K. Such},
title = {Controlling Endosomal Escape Using pH-Responsive Nanoparticles with Tunable Disassembly},
journal = {ACS Applied Nano Materials},
year = {2018},
volume = {1},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://pubs.acs.org/doi/10.1021/acsanm.8b00338},
number = {7},
pages = {3164--3173},
doi = {10.1021/acsanm.8b00338}
}
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MLA
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Kongkatigumjorn, Nachnicha, et al. “Controlling Endosomal Escape Using pH-Responsive Nanoparticles with Tunable Disassembly.” ACS Applied Nano Materials, vol. 1, no. 7, Jun. 2018, pp. 3164-3173. https://pubs.acs.org/doi/10.1021/acsanm.8b00338.
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