ACS Catalysis

, volume 14 , issue 21 , pages 16344-16352

Cu-Albumin Artificial Enzymes with Peroxidase and Oxidase Activity for Stereoselective Oxidations

Maham Liaqat ^{1, 2}

Emma McDonald ^{1, 2, 3}

Robert Jervine Valdez Ortega ^{1, 2, 3}

Aaron Lopes ^{4, 5, 6, 7, 8, 9}

Flavia Codreanu ^{4, 6, 7, 10, 11, 12}

Hannah Carlisle ^{4, 6, 7, 13, 14, 15}

Challa V Kumar ^{1, 2, 3, 16, 17}

Xudong Yao ^{1, 2, 17}

James Rusling ^{1, 2, 3, 16, 17, 18, 19, 20, 21}

Jie He ^{1, 2, 3, 16, 17}

Hide authors affiliations Show authors affiliations: 21 affiliations

Department of Chemistry, Storrs, United States |

University of Connecticut, Storrs, United States |

Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States |

⁴

Division of Gastroenterology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States

Harvard University

Brigham and Women's Hospital

⁵

Koch Institute For Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States |

⁶

Division of Gastroenterology, Department of Medicine, Brigham and Women’s Hospital, Boston, United States |

⁷

Harvard Medical School, Boston, United States |

⁸

Koch Institute for Integrative Cancer Research, Cambridge, United States |

⁹

Massachusetts Institute of Technology, Cambridge, United States |

¹⁰

Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada |

¹¹

Department of Chemistry, Toronto, Canada |

¹²

University of TorontoToronto, Canada |

¹³

Department of Chemistry, Northeastern University, Boston, Massachusetts 02115 United States |

¹⁴

Department of Chemistry, Boston, United States |

¹⁵

Northeastern University, Boston, United States |

¹⁶

Institute of Materials Science, University of Connecticut, Storrs, Connecticut 06269, United States |

¹⁷

Institute of Materials Science, Storrs, United States |

¹⁸

Department of Surgery and Neag Cancer Center, Uconn Health, Farmington, Connecticut 06030, United States |

¹⁹

School of Chemistry, National University of Ireland at Galway, Galway H91 TK33, Ireland |

²⁰

Department of Surgery and Neag Cancer Center, Farmington, United States |

²¹

UConn Health, Farmington, United States |

Publication type: Journal Article

Publication date: 2024-10-22

American Chemical Society (ACS)

ACS Catalysis

scimago Q1

wos Q1

SJR: 3.782

CiteScore: 19.5

Impact factor: 13.1

ISSN: 21555435

DOI: 10.1021/acscatal.4c05732

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Abstract

We herein report a design of artificial enzymes by incorporating a synthetic copper complex into noncatalytic bovine serum albumin (Cu-BSA) to carry out stereoselective oxidation. This Cu-BSA catalyst with stably bound Cu complex as a cofactor shows peroxidase-like activity to catalyze epoxidation of styrene with high chiral selectivity (>99%) to R-styrene epoxide. With the electrochemical conversion of Cu2+ to Cu+, Cu-BSA also exhibits oxidase-like activity to selectively reduce oxygen to hydrogen peroxide (H2O2), which can be combined with its peroxidase function to drive oxidation of C═C bonds using air. This artificial enzymatic system holds promise for chiral-selective transformations of non-natural substances and highlights the versatility of noncatalytic proteins in the design of artificial enzymes.

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GOST |

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Liaqat M. et al. Cu-Albumin Artificial Enzymes with Peroxidase and Oxidase Activity for Stereoselective Oxidations // ACS Catalysis. 2024. Vol. 14. No. 21. pp. 16344-16352.

GOST all authors (up to 50) Copy

Liaqat M., McDonald E., Ortega R. J. V., Lopes A., Codreanu F., Carlisle H., Kumar C. V., Yao X., Rusling J., He J. Cu-Albumin Artificial Enzymes with Peroxidase and Oxidase Activity for Stereoselective Oxidations // ACS Catalysis. 2024. Vol. 14. No. 21. pp. 16344-16352.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1021/acscatal.4c05732

UR - https://pubs.acs.org/doi/10.1021/acscatal.4c05732

TI - Cu-Albumin Artificial Enzymes with Peroxidase and Oxidase Activity for Stereoselective Oxidations

T2 - ACS Catalysis

AU - Liaqat, Maham

AU - McDonald, Emma

AU - Ortega, Robert Jervine Valdez

AU - Lopes, Aaron

AU - Codreanu, Flavia

AU - Carlisle, Hannah

AU - Kumar, Challa V

AU - Yao, Xudong

AU - Rusling, James

AU - He, Jie

PY - 2024

DA - 2024/10/22

PB - American Chemical Society (ACS)

SP - 16344-16352

IS - 21

VL - 14

SN - 2155-5435

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2024_Liaqat,

author = {Maham Liaqat and Emma McDonald and Robert Jervine Valdez Ortega and Aaron Lopes and Flavia Codreanu and Hannah Carlisle and Challa V Kumar and Xudong Yao and James Rusling and Jie He},

title = {Cu-Albumin Artificial Enzymes with Peroxidase and Oxidase Activity for Stereoselective Oxidations},

journal = {ACS Catalysis},

year = {2024},

volume = {14},

publisher = {American Chemical Society (ACS)},

month = {oct},

url = {https://pubs.acs.org/doi/10.1021/acscatal.4c05732},

number = {21},

pages = {16344--16352},

doi = {10.1021/acscatal.4c05732}

}

MLA

Cite this

MLA Copy

Liaqat, Maham, et al. “Cu-Albumin Artificial Enzymes with Peroxidase and Oxidase Activity for Stereoselective Oxidations.” ACS Catalysis, vol. 14, no. 21, Oct. 2024, pp. 16344-16352. https://pubs.acs.org/doi/10.1021/acscatal.4c05732.

Publisher

American Chemical Society (ACS)

Journal

ACS Catalysis

scimago Q1

wos Q1

SJR

3.782

CiteScore

19.5

Impact factor

13.1

ISSN

21555435 (Print, Electronic)

Profiles

James F Rusling