Constructive On-DNA Abramov Reaction and Pudovik Reaction for DEL Synthesis
Zhaomei Sun
1
,
Lingqian Xiao
1
,
Yahui Chen
1
,
Ya-Hui Chen
1
,
Jiangying Wang
1
,
Fanming Zeng
1
,
Huanqing Zhang
1
,
Jie Zhang
1
,
Kexin Yang
2
,
Yun Jin Hu
1
1
Pharmaron (Ningbo) Technology Development Co., Ltd. No. 800 Bin-Hai fourth Road, Hangzhou Bay New Zone, Ningbo, 315336 China
|
2
Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing, 100176 P. R. China
|
Publication type: Journal Article
Publication date: 2023-03-10
scimago Q1
wos Q2
SJR: 0.805
CiteScore: 5.8
Impact factor: 4.0
ISSN: 19485875
PubMed ID:
37077381
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
Organophosphonic compounds are distinctive among natural products in terms of stability and mimicry. Numerous synthetic organophosphonic compounds, including pamidronic acid, fosmidromycin, and zoledronic acid, are approved drugs. DNA encoded library technology (DELT) is a well-established platform for identifying small molecule recognition to target protein of interest (POI). Therefore, it is imperative to create an efficient procedure for the on-DNA synthesis of α-hydroxy phosphonates for DEL builds.
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Metrics
13
Total citations:
13
Citations from 2025:
7
(53.85%)
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GOST
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Sun Z. et al. Constructive On-DNA Abramov Reaction and Pudovik Reaction for DEL Synthesis // ACS Medicinal Chemistry Letters. 2023. Vol. 14. No. 4. pp. 473-478.
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Sun Z., Xiao L., Chen Y., Chen Y., Wang J., Zeng F., Zhang H., Zhang J., Yang K., Hu Y. J. Constructive On-DNA Abramov Reaction and Pudovik Reaction for DEL Synthesis // ACS Medicinal Chemistry Letters. 2023. Vol. 14. No. 4. pp. 473-478.
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RIS
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TY - JOUR
DO - 10.1021/acsmedchemlett.3c00022
UR - https://pubs.acs.org/doi/10.1021/acsmedchemlett.3c00022
TI - Constructive On-DNA Abramov Reaction and Pudovik Reaction for DEL Synthesis
T2 - ACS Medicinal Chemistry Letters
AU - Sun, Zhaomei
AU - Xiao, Lingqian
AU - Chen, Yahui
AU - Chen, Ya-Hui
AU - Wang, Jiangying
AU - Zeng, Fanming
AU - Zhang, Huanqing
AU - Zhang, Jie
AU - Yang, Kexin
AU - Hu, Yun Jin
PY - 2023
DA - 2023/03/10
PB - American Chemical Society (ACS)
SP - 473-478
IS - 4
VL - 14
PMID - 37077381
SN - 1948-5875
ER -
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BibTex (up to 50 authors)
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@article{2023_Sun,
author = {Zhaomei Sun and Lingqian Xiao and Yahui Chen and Ya-Hui Chen and Jiangying Wang and Fanming Zeng and Huanqing Zhang and Jie Zhang and Kexin Yang and Yun Jin Hu},
title = {Constructive On-DNA Abramov Reaction and Pudovik Reaction for DEL Synthesis},
journal = {ACS Medicinal Chemistry Letters},
year = {2023},
volume = {14},
publisher = {American Chemical Society (ACS)},
month = {mar},
url = {https://pubs.acs.org/doi/10.1021/acsmedchemlett.3c00022},
number = {4},
pages = {473--478},
doi = {10.1021/acsmedchemlett.3c00022}
}
Cite this
MLA
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Sun, Zhaomei, et al. “Constructive On-DNA Abramov Reaction and Pudovik Reaction for DEL Synthesis.” ACS Medicinal Chemistry Letters, vol. 14, no. 4, Mar. 2023, pp. 473-478. https://pubs.acs.org/doi/10.1021/acsmedchemlett.3c00022.