Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects
Publication type: Journal Article
Publication date: 2015-07-20
scimago Q1
wos Q2
SJR: 0.805
CiteScore: 5.8
Impact factor: 4.0
ISSN: 19485875
PubMed ID:
26288690
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
Carbazoles represent a family of tricyclic compounds that widely appeared in nature. Numerous studies have revealed a diverse array of bioactivity associated with this scaffold. In the present study, a novel and highly efficient methodology for preparing 1,3-dihydroxy-2-carboxycarbazole from indole-3-acetic acid and Meldrum's acid was developed. Furthermore, biological characterization demonstrated that this multisubstituted carbazole analogue exhibited inhibitory activity on Aβ aggregation, antioxidative properties, and promising neuroprotective activities in a cellular model of Alzheimer's disease, thus further supporting the valuable application of this synthetic methodology in search for effective neuroprotectants.
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Total citations:
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Citations from 2024:
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(20%)
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GOST
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Liu K., Zhang S. Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects // ACS Medicinal Chemistry Letters. 2015. Vol. 6. No. 8. pp. 894-897.
GOST all authors (up to 50)
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Liu K., Zhang S. Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects // ACS Medicinal Chemistry Letters. 2015. Vol. 6. No. 8. pp. 894-897.
Cite this
RIS
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TY - JOUR
DO - 10.1021/acsmedchemlett.5b00158
UR - https://doi.org/10.1021/acsmedchemlett.5b00158
TI - Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects
T2 - ACS Medicinal Chemistry Letters
AU - Liu, Kai
AU - Zhang, Shijun
PY - 2015
DA - 2015/07/20
PB - American Chemical Society (ACS)
SP - 894-897
IS - 8
VL - 6
PMID - 26288690
SN - 1948-5875
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2015_Liu,
author = {Kai Liu and Shijun Zhang},
title = {Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects},
journal = {ACS Medicinal Chemistry Letters},
year = {2015},
volume = {6},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://doi.org/10.1021/acsmedchemlett.5b00158},
number = {8},
pages = {894--897},
doi = {10.1021/acsmedchemlett.5b00158}
}
Cite this
MLA
Copy
Liu, Kai, and Shijun Zhang. “Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects.” ACS Medicinal Chemistry Letters, vol. 6, no. 8, Jul. 2015, pp. 894-897. https://doi.org/10.1021/acsmedchemlett.5b00158.