ACS Medicinal Chemistry Letters

, том 6 , издание 8 , страницы 894-897

Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects

Тип публикации: Journal Article

Дата публикации: 2015-07-20

American Chemical Society (ACS)

ACS Medicinal Chemistry Letters

scimago Q1

wos Q2

white level БС1

SJR: 0.697

CiteScore: 5.8

Impact factor: 4

ISSN: 19485875

DOI: 10.1021/acsmedchemlett.5b00158

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PubMed ID: 26288690

Organic Chemistry

Drug Discovery

Biochemistry

Краткое описание

Carbazoles represent a family of tricyclic compounds that widely appeared in nature. Numerous studies have revealed a diverse array of bioactivity associated with this scaffold. In the present study, a novel and highly efficient methodology for preparing 1,3-dihydroxy-2-carboxycarbazole from indole-3-acetic acid and Meldrum's acid was developed. Furthermore, biological characterization demonstrated that this multisubstituted carbazole analogue exhibited inhibitory activity on Aβ aggregation, antioxidative properties, and promising neuroprotective activities in a cellular model of Alzheimer's disease, thus further supporting the valuable application of this synthetic methodology in search for effective neuroprotectants.

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Liu K., Zhang S. Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects // ACS Medicinal Chemistry Letters. 2015. Vol. 6. No. 8. pp. 894-897.

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Liu K., Zhang S. Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects // ACS Medicinal Chemistry Letters. 2015. Vol. 6. No. 8. pp. 894-897.

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TY - JOUR

DO - 10.1021/acsmedchemlett.5b00158

UR - https://doi.org/10.1021/acsmedchemlett.5b00158

TI - Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects

T2 - ACS Medicinal Chemistry Letters

AU - Liu, Kai

AU - Zhang, Shijun

PY - 2015

DA - 2015/07/20

PB - American Chemical Society (ACS)

SP - 894-897

IS - 8

VL - 6

PMID - 26288690

SN - 1948-5875

ER -

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@article{2015_Liu,

author = {Kai Liu and Shijun Zhang},

title = {Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects},

journal = {ACS Medicinal Chemistry Letters},

year = {2015},

volume = {6},

publisher = {American Chemical Society (ACS)},

month = {jul},

url = {https://doi.org/10.1021/acsmedchemlett.5b00158},

number = {8},

pages = {894--897},

doi = {10.1021/acsmedchemlett.5b00158}

}

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Liu, Kai, and Shijun Zhang. “Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects.” ACS Medicinal Chemistry Letters, vol. 6, no. 8, Jul. 2015, pp. 894-897. https://doi.org/10.1021/acsmedchemlett.5b00158.

Издатель

American Chemical Society (ACS)

Журнал

ACS Medicinal Chemistry Letters

scimago Q1

wos Q2

white level БС1

SJR

0.697

CiteScore

5.8

Impact factor

ISSN

19485875 (Print, Electronic)

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