Open Access
ACS Omega, volume 5, issue 24, pages 14689-14701
Shaking-Induced Aggregation and Flotation in Immunoglobulin Dispersions: Differences between Water and Water–Ethanol Mixtures
Bunkin Nikolai F.
1, 2
,
Shkirin A V
2, 3
,
Ninham B. W.
4
,
Chirikov Sergey N
3
,
Chaikov L.L.
5
,
Penkov Nikita V.
6
,
Kozlov V A
1, 2
,
Publication type: Journal Article
Publication date: 2020-06-12
PubMed ID:
32596606
General Chemistry
General Chemical Engineering
Abstract
Structural characterization by three complementary methods of laser diagnostics (dynamic light scattering, laser phase microscopy, and laser polarimetric scatterometry) has established that shaking of immunoglobulin G (IgG) dispersions in water and ethanol–water mixtures (36.7 vol %) results in two effects. First, it intensifies the aggregation of IgG macromolecules. Second, it generates bubbles with a size range that is different in each solvent. The aggregation is enhanced in ethanol–water mixtures because of IgG denaturation. IgG aggregates have a size of ∼300 nm in water and ∼900 nm in ethanol–water mixtures. The flotation of IgG is much more efficient in water. This can be explained by a better adsorption of IgG particles (molecules and aggregates) on bubbles in water as compared to ethanol–water mixtures. Bulk nanobubbles and their association with IgG aggregates were visualized by laser phase microscopy in water but were not detected in ethanol–water mixtures. Therefore, the nanobubble flotation mechanism for IgG aggregates acting in water is not feasible for ethanol–water mixtures.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Bunkin N. F. et al. Shaking-Induced Aggregation and Flotation in Immunoglobulin Dispersions: Differences between Water and Water–Ethanol Mixtures // ACS Omega. 2020. Vol. 5. No. 24. pp. 14689-14701.
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Bunkin N. F., Shkirin A. V., Ninham B. W., Chirikov S. N., Chaikov L., Penkov N. V., Kozlov V. A., Gudkov S. V. Shaking-Induced Aggregation and Flotation in Immunoglobulin Dispersions: Differences between Water and Water–Ethanol Mixtures // ACS Omega. 2020. Vol. 5. No. 24. pp. 14689-14701.
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TY - JOUR
DO - 10.1021/acsomega.0c01444
UR - https://doi.org/10.1021%2Facsomega.0c01444
TI - Shaking-Induced Aggregation and Flotation in Immunoglobulin Dispersions: Differences between Water and Water–Ethanol Mixtures
T2 - ACS Omega
AU - Chirikov, Sergey N
AU - Bunkin, Nikolai F.
AU - Penkov, Nikita V.
AU - Gudkov, Sergey V.
AU - Shkirin, A V
AU - Ninham, B. W.
AU - Chaikov, L.L.
AU - Kozlov, V A
PY - 2020
DA - 2020/06/12 00:00:00
PB - American Chemical Society (ACS)
SP - 14689-14701
IS - 24
VL - 5
PMID - 32596606
SN - 2470-1343
ER -
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@article{2020_Bunkin,
author = {Sergey N Chirikov and Nikolai F. Bunkin and Nikita V. Penkov and Sergey V. Gudkov and A V Shkirin and B. W. Ninham and L.L. Chaikov and V A Kozlov},
title = {Shaking-Induced Aggregation and Flotation in Immunoglobulin Dispersions: Differences between Water and Water–Ethanol Mixtures},
journal = {ACS Omega},
year = {2020},
volume = {5},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://doi.org/10.1021%2Facsomega.0c01444},
number = {24},
pages = {14689--14701},
doi = {10.1021/acsomega.0c01444}
}
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MLA
Copy
Bunkin, Nikolai F., et al. “Shaking-Induced Aggregation and Flotation in Immunoglobulin Dispersions: Differences between Water and Water–Ethanol Mixtures.” ACS Omega, vol. 5, no. 24, Jun. 2020, pp. 14689-14701. https://doi.org/10.1021%2Facsomega.0c01444.