Open Access
Open access
American Chemical Society (ACS)
ACS Omega
,  volume 7 ,  issue 7 ,  pages 6007-6023

Understanding OxymaPure as a Peptide Coupling Additive: A Guide to New Oxyma Derivatives

Srinivasa Rao Manne 1
, 
Anamika Sharma 1, 2, 3
, 
Andrius Sazonovas 4
, 
Ayman El-Faham 5
, 
Beatriz G. de la Torre 1, 2
, 
Fernando Albericio 1, 6, 7
1
 
2
 
3
 
Department of Chemistry, Prayoga Institute of Education Research (PIER), Bangalore 560082, India | 
4
 
Advanced Chemistry Development, Inc. (ACD/Labs), 8 King Street East, Suite 107, Toronto, Ontario M5C 1B5, Canada | 
5
 
6
 
7
 
Publication type: Journal Article
Publication date: 2022-02-09
American Chemical Society (ACS)
scimago Q1
wos Q2
SJR: 0.773
CiteScore: 7.1
Impact factor: 4.3
ISSN: 24701343
General Chemistry
General Chemical Engineering
Abstract
An in silico study, using the GALAS algorithm available in ACD/PhysChem Suite, was performed to calculate the pKa(s) of various oximes with potential application as peptide coupling additives. Among the known oximes and predicted structures, OxymaPure is superior based on the pKa values calculated, confirming the results described in the literature and validating this algorithm for further use in that field. Among the nondescribed oximes, based on pKa calculation, ethyl 2-(hydroxyimino)-2-nitroacetate seems to be a potential candidate to be used as an additive during peptide coupling.
Found 
Found 

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GOST |
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GOST Copy
Manne S. R. et al. Understanding OxymaPure as a Peptide Coupling Additive: A Guide to New Oxyma Derivatives // ACS Omega. 2022. Vol. 7. No. 7. pp. 6007-6023.
GOST all authors (up to 50) Copy
Manne S. R., Sharma A., Sazonovas A., El-Faham A., de la Torre B. G., Albericio F. Understanding OxymaPure as a Peptide Coupling Additive: A Guide to New Oxyma Derivatives // ACS Omega. 2022. Vol. 7. No. 7. pp. 6007-6023.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1021/acsomega.1c06342
UR - https://doi.org/10.1021/acsomega.1c06342
TI - Understanding OxymaPure as a Peptide Coupling Additive: A Guide to New Oxyma Derivatives
T2 - ACS Omega
AU - Manne, Srinivasa Rao
AU - Sharma, Anamika
AU - Sazonovas, Andrius
AU - El-Faham, Ayman
AU - de la Torre, Beatriz G.
AU - Albericio, Fernando
PY - 2022
DA - 2022/02/09
PB - American Chemical Society (ACS)
SP - 6007-6023
IS - 7
VL - 7
PMID - 35224362
SN - 2470-1343
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2022_Manne,
author = {Srinivasa Rao Manne and Anamika Sharma and Andrius Sazonovas and Ayman El-Faham and Beatriz G. de la Torre and Fernando Albericio},
title = {Understanding OxymaPure as a Peptide Coupling Additive: A Guide to New Oxyma Derivatives},
journal = {ACS Omega},
year = {2022},
volume = {7},
publisher = {American Chemical Society (ACS)},
month = {feb},
url = {https://doi.org/10.1021/acsomega.1c06342},
number = {7},
pages = {6007--6023},
doi = {10.1021/acsomega.1c06342}
}
MLA
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MLA Copy
Manne, Srinivasa Rao, et al. “Understanding OxymaPure as a Peptide Coupling Additive: A Guide to New Oxyma Derivatives.” ACS Omega, vol. 7, no. 7, Feb. 2022, pp. 6007-6023. https://doi.org/10.1021/acsomega.1c06342.