Bioconjugate Chemistry

, volume 25 , issue 7 , pages 1370-1374

New Generation of Bioorthogonally Applicable Fluorogenic Dyes with Visible Excitations and Large Stokes Shifts

András Herner ¹

G Estrada Girona ²

Ivana Nikić ²

M. Kállay ³

Edward A. Lemke ²

Péter Kele ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

“Lendület” Chemical Biology Research Group, Research Centre for Natural Sciences, Institute of Organic Chemistry, Hungarian Academy of Sciences, Magyar tudósok krt. 2., H-1117 Budapest, Hungary |

Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1., D-69117 Heidelberg, Germany |

MTA-BME “Lendület” Quantum Chemistry Research Group, Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, P.O. Box 91, H-1521 Budapest, Hungary |

Publication type: Journal Article

Publication date: 2014-06-23

American Chemical Society (ACS)

Bioconjugate Chemistry

scimago Q1

wos Q1

SJR: 1.035

CiteScore: 7.5

Impact factor: 3.9

ISSN: 10431802, 15204812

DOI: 10.1021/bc500235p

Copy DOI

PubMed ID: 24932756

Organic Chemistry

Pharmacology

Pharmaceutical Science

Biotechnology

Bioengineering

Biomedical Engineering

Abstract

Synthesis of a set of new, azide bearing, biorthogonally applicable fluorogenic dyes with large Stokes shifts is presented herein. To assess the fluorogenic performance of these new dyes we have labeled a genetically modulated, cyclooctyne-bearing protein in lysate medium. Studies showed that the labels produce specific signal with minimal background fluorescence. We also provide theoretical insights into the design of such fluorogenic labels.

Found

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Danilkina Natalia

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Saint Petersburg State University

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h-index: 29

Lomonosov Moscow State University

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Luponosov Yuriy

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Enikolopov Institute of Synthetic Polymeric Materials of the Russian Academy of Sciences

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Vil' Vera

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h-index: 24

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

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1 citation

Yaremenko Ivan

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60 publications, 1 567 citations, 5 reviews

h-index: 24

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

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Organic Chemistry

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Gorbunova Yuliya

DSc in Chemistry, professor, full member of the Russian Academy of Sciences

284 publications, 4 398 citations, 65 reviews

h-index: 34

Lomonosov Moscow State University

Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences

A.N. Frumkin Institute of Physical Chemistry and Electrochemistry of the Russian Academy of Sciences

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Volcho Konstantin

DSc in Chemistry, professor of the Russian Academy of Sciences

279 publications, 3 898 citations, 65 reviews

h-index: 31

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences

1 citation

Osipov Sergey

DSc in Chemistry

138 publications, 2 739 citations, 3 reviews

h-index: 29

A.N.Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences

1 citation

Gazizov Almir

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DSc in Chemistry

157 publications, 889 citations, 23 reviews

h-index: 14

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Heterocyclic compounds

Organic Chemistry

Organophosphorus chemistry

1 citation

Karasik Andrey

DSc in Chemistry, professor, associate member of the Russian Academy of Sciences

224 publications, 2 599 citations

h-index: 26

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

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1 citation

Dotsenko Viktor

DSc in Chemistry, professor

244 publications, 2 741 citations, 2 reviews

h-index: 22

North Caucasus Federal University

Kuban State University

Research interests

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Zagidullin Almaz

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PhD in Chemistry

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A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

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Chemistry of organic and organoelement compounds; chemistry of polymers; production of materials

Coordination chemistry of phosphorus

Organoelement chemistry

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Synthesis of chiral phosphorus-containing ligands

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Aksenov Aleksandr

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North Caucasus Federal University

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Sosnovskikh Vyacheslav

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Ural Federal University

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Ilkin Vladimir

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Ural Federal University

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h-index: 25

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

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Green chemistry

Organic Chemistry

Organic electrochemistry

Organic synthesis

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Plant protection

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Tikhomirov Alexander

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DSc in Chemistry, associate professor

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h-index: 17

Mendeleev University of Chemical Technology of Russia

Gause Institute of New Antibiotics

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1 citation

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h-index: 12

A.E. Favorsky Irkutsk Institute of Chemistry of the Siberian Branch of the Russian Academy of Sciences

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h-index: 9

Ural Federal University

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GOST |

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GOST Copy

Herner A. et al. New Generation of Bioorthogonally Applicable Fluorogenic Dyes with Visible Excitations and Large Stokes Shifts // Bioconjugate Chemistry. 2014. Vol. 25. No. 7. pp. 1370-1374.

GOST all authors (up to 50) Copy

Herner A., Estrada Girona G., Nikić I., Kállay M., Lemke E. A., Kele P. New Generation of Bioorthogonally Applicable Fluorogenic Dyes with Visible Excitations and Large Stokes Shifts // Bioconjugate Chemistry. 2014. Vol. 25. No. 7. pp. 1370-1374.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/bc500235p

UR - https://doi.org/10.1021/bc500235p

TI - New Generation of Bioorthogonally Applicable Fluorogenic Dyes with Visible Excitations and Large Stokes Shifts

T2 - Bioconjugate Chemistry

AU - Herner, András

AU - Estrada Girona, G

AU - Nikić, Ivana

AU - Kállay, M.

AU - Lemke, Edward A.

AU - Kele, Péter

PY - 2014

DA - 2014/06/23

PB - American Chemical Society (ACS)

SP - 1370-1374

IS - 7

VL - 25

PMID - 24932756

SN - 1043-1802

SN - 1520-4812

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2014_Herner,

author = {András Herner and G Estrada Girona and Ivana Nikić and M. Kállay and Edward A. Lemke and Péter Kele},

title = {New Generation of Bioorthogonally Applicable Fluorogenic Dyes with Visible Excitations and Large Stokes Shifts},

journal = {Bioconjugate Chemistry},

year = {2014},

volume = {25},

publisher = {American Chemical Society (ACS)},

month = {jun},

url = {https://doi.org/10.1021/bc500235p},

number = {7},

pages = {1370--1374},

doi = {10.1021/bc500235p}

}

MLA

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MLA Copy

Herner, András, et al. “New Generation of Bioorthogonally Applicable Fluorogenic Dyes with Visible Excitations and Large Stokes Shifts.” Bioconjugate Chemistry, vol. 25, no. 7, Jun. 2014, pp. 1370-1374. https://doi.org/10.1021/bc500235p.

Publisher

American Chemical Society (ACS)

Journal

Bioconjugate Chemistry

scimago Q1

wos Q1

SJR

1.035

CiteScore

7.5

Impact factor

3.9

ISSN

10431802 (Print)

15204812 (Electronic)